Tough hydrogels
The invention provides fabricated tough hydrogels, hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the tough hydrogels, or the hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled hydrogel particles and making crosslinked tough hydrogels, and crosslinked tough hydrogel-containing compositions also are disclosed herein.
1. A method of making a tough hydrogel, the method comprising:
(a) heating a polymeric material and a gellant and mixing the heated polymeric material with the heated gellant to form a gelling solution having a temperature above room temperature and cooling the gelling solution to room temperature thereby forming an as-gelled hydrogel, the gellant being a non-solvent for the hydrogel;
(b) annealing the as-gelled hydrogel by heating to a temperature that is below the melting point of the as-gelled hydrogel that is being annealed, wherein the non-solvent gellant remains in the as-gelled hydrogel during annealing and prevents collapse of porosity in the as-gelled hydrogel; and
(c) cooling the heated as-gelled hydrogel to room temperature, thereby forming a tough hydrogel,
wherein the gellant comprises polyethylene glycol.
2. The method according to claim 1 , wherein the as-gelled hydrogel is annealed in air, an inert gas, or under vacuum.
3. The method of claim 1 , wherein prior to the annealing step (b), the as-gelled hydrogel is dehydrated by one or more methods selected from the group consisting of:
(i) air-drying the as-gelled hydrogel at room temperature,
(ii) heating the as-gelled hydrogel to a temperature below the melting point of the as-gelled hydrogel, and
(iii) placing the as-gelled hydrogel under vacuum.
4. The method of claim 3 further comprising re-hydrating the dehydrated hydrogel by placing the dehydrated hydrogel in:
water, saline solution, Ringer's solution, buffer solution,
or in a humid chamber, wherein the placing is performed at room temperature or at an elevated temperature that is below the melting point of the as-gelled hydrogel.
5. The method according to claim 1 , wherein the non-solvent gellant is subsequently removed from the as-gelled hydrogel after annealing.
6. The method according to claim 5 , wherein the non-solvent gellant is removed from the as-gelled hydrogel by:
(i) immersing the as-gelled hydrogel in water, organic solvents, or salt solutions, or
(ii) placing the as-gelled hydrogel in a supercritical fluid.
7. The method according to claim 1 , wherein the polymeric material is polyvinyl alcohol (PVA), a copolymer of PVA, or a blend of PVA with another polymer.
8. The method according to claim 1 , wherein the as-gelled hydrogel is deformed at a temperature that is below the melting point of the as-gelled hydrogel before and/or after annealing.
9. A tough hydrogel made by the method according to claim 1 .
10. A medical implant comprising the tough hydrogel according to claim 9 .
11. The medical implant according to claim 10 which is further sterilized by radiation sterilization, gas plasma sterilization, or ethylene oxide sterilization.
12. The medical implant of claim 10 which is an interpositional device or a mosaicplasty plug.
13. The medical implant of claim 12 , wherein the interpositional device is a unispacer, wherein the unispacer is a free floating articular implant in a human joint.
14. The medical implant of claim 13 , wherein the human joint is a knee, a hip, a shoulder, an elbow, or an upper or a lower extremity joint.