Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
1. A nitric oxide-releasing particle comprising:
a co-condensed silica network comprising aminoethylaminopropyl trimethoxysilane (AEAP3) and tetra methyl orthosilicate (TMOS), wherein the AEAP3 is distributed throughout the nitric oxide-releasing particle, and wherein the AEAP3 comprises N-diazeniumdiolate functionalized AEAP3.
2. The nitric oxide-releasing particle of claim 1 , wherein the AEAP3 is present in a mol % of 1% to 90%.
3. The nitric oxide-releasing particle of claim 1 , wherein the AEAP3 is present in a mol % of about 50%.
4. The nitric oxide-releasing particle of claim 1 , wherein the N-diazeniumdiolate functionalized AEAP3 comprises a sodium cation.
5. The nitric oxide-releasing particle of claim 1 , wherein the N-diazeniumdiolate functionalized AEAP3 comprises a potassium cation.
6. The nitric oxide-releasing particle of claim 1 , wherein the N-diazeniumdiolate functionalized AEAP3 comprises a lithium cation.
7. The nitric oxide-releasing particle of claim 2 , wherein the TMOS is present in a mol % of 10% to 99%.