Mycobacterium tuberculosis specific peptides for detection of infection or immunization in non-human primates
The present invention relates to novel peptides that may be used in whole or in combination for the detection of Mycobacterium tuberculosis infection. In particular, the present invention relates to compositions and methods involving detection of antibodies contained in the blood of non-human primates that arise from an infection from M. tuberculosis or vaccination using an epitope specific inoculation. More particularly, the present invention provides a means to distinguish early, active, and latent M. tuberculosis infection. More particularly, the present invention describes an immunological diagnostic mechanism for the detection of M. tuberculosis infection.
1. An immunoassay device comprising a first capture agent comprising a base peptide comprising SEQ ID NO:141 and up to 5 amino acids on either or both of the amino- or carboxy-terminus of the base peptide, a second capture reagent comprising a base peptide comprising SEQ ID NO:145 and up to 5 amino acids on either or both of the amino- or carboxy-terminus of the base peptide, a third capture reagent comprising a peptide encoding SEQ ID NO:147; and a fourth capture reagent comprising a peptide encoding SEQ ID NO:98.
2. The immunoassay device of claim 1 , further comprising a surface having at least one capture agent displayed thereon.