Fusion peptide designed to reduce plaque bacteria and yeast in the oral cavity
View Patent ↗The present invention relates generally to dental diseases, caries and periodontal disease. More specifically, the invention relates to Lactoferrin and PAK fusion peptides (PAK-LF), along with therapeutic, diagnostic and research uses for these polypeptides. The present invention also provides methods of treating dental diseases, caries and periodontal disease.
1. A composition for inhibiting bacterial growth in the oral cavity comprising a fusion peptide comprising:
i. a lysine form of a Lactoferrin polypeptide; and
ii. a PAK polypeptide,
wherein the fusion peptide consists essentially of SEQ ID NO: 5.
2. The composition of claim 1 , wherein the composition further comprises a pharmaceutically acceptable excipient.
3. The composition of claim 1 , wherein the composition further comprises a surfactant molecule.
4. The composition of claim 3 , wherein the surfactant is sodium lauryl sulfate.
5. The composition of claim 4 , wherein the sodium lauryl sulfate is present in an effective amount to allow the composition to penetrate a biofilm.
6. The composition of claim 2 , wherein the composition is a dosage form selected from the group consisting of a food, a food additive, dentifrices, gels, toothpaste, mouthwash, aerosol spray, pump spray, dental floss, denture wash, denture adhesives, chewing gum, candy, chewable tablets and solution.
7. The composition of claim 1 , further comprising an antibacterial agent, an antimicrobial agent, an antifungal agent, anti-candidal agent, or a combination thereof.
8. The composition of claim 1 , further comprising a statherin polypeptide comprising SEQ ID NO: 2.
9. The composition of claim 1 , further comprising a STAT-LF fusion peptide comprising:
i. a lysine form of a Lactoferrin polypeptide; and
ii. a Statherin polypeptide.
10. The composition of claim 9 , wherein the STAT-LF fusion peptide comprises SEQ ID NO: 3.
11. A fusion peptide consisting essentially of SEQ ID NO: 5.
12. A composition for inhibiting bacterial growth in the oral cavity comprising the fusion peptide of claim 11 .
13. A method for inhibiting bacteria and/or yeast in the oral cavity comprising administering an effective amount of the composition of claim 1 to a patient in need thereof.
14. The method of claim 13 , wherein the composition further comprises a pharmaceutically acceptable excipient.
15. The method of claim 13 , wherein the composition further comprises a surfactant.
16. The method of claim 15 , wherein the surfactant is sodium lauryl sulfate.
17. The method of claim 16 , wherein the sodium lauryl sulfate is an effective amount to allow the composition to penetrate a biofilm.
18. The method of claim 13 , wherein the composition is administered via a dosage form selected from the group consisting of a food, a food additive, dentifrices, gels, toothpaste, mouthwash, dental floss, denture wash, denture adhesives, chewing gum, candy, chewable tablets and solution.
19. The method of claim 13 , wherein the composition further comprises an antibacterial agent, an antimicrobial agent, antifungal agent, anti-candidal agent, or a combination thereof.