4-(8-methoxy-1-((1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1 H-imidazo[4,5-C]quinolin-7-yl)-3,5-dimethylisoxazole and its use as bromodomain inhibitor
Novel quinoline compounds pharmaceutical compositions containing such compounds and their use in therapy.
1. A method of prevention and treatment of viral infections in a subject in need thereof which comprises administering a therapeutically effective amount of a compound of formula (I) which is 4-(8-methoxy-1-(1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole
or a pharmaceutically acceptable salt thereof.
2. A method according to claim 1 wherein the compound of formula (I) is a compound of formula (IA) which is 4-(8-methoxy-1-((R)-1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole
or a salt thereof.
3. A method according to claim 1 wherein the compound of formula (I) is a compound of formula (IB) which is 4-(8-methoxy-1-((S)-1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole
or a salt thereof.
4. A method according to claim 1 in which the compound is in the form of a free base.
5. A method according to claim 1 in which the viral infection is selected from herpes virus, human papilloma virus, adenovirus and poxvirus and other DNA viruses.
6. A method according to claim 1 in which the viral infection is selected from herpes simplex infections and reactivations, cold sores, herpes zoster infections and reactivations, chickenpox, shingles, human papilloma virus, human immunodeficiency virus (HIV), cervical neoplasia, adenovirus infections, poxvirus infections and African swine fever virus.
7. A method according to claim 1 in which the subject is a human subject.