Valveless pharmaceutical infusion system
A valveless pharmaceutical infusion system for delivery of a pharmaceutical, such as a radiopharmaceutical, is described. The device may include two or more roller pumps, a fluid path set including a confidence, and a measuring device for measuring a property of the pharmaceutical. Methods for delivering a pharmaceutical, such as a radiopharmaceutical, using a valveless pharmaceutical infusion system are also describe.
1. A device for delivering a pharmaceutical, the device comprising:
two or more roller pumps comprising at least a first roller pump and a second roller pump; and
a fluid path set wherein a portion of the fluid path set is reversibly received by the two or more roller pumps, the fluid path set comprising:
a first tubing section fluidly connecting a pharmaceutical source to a confluence, wherein a flow of fluid through the first tubing section is controlled by the first roller pump;
a second tubing section fluidly connecting a source of medical fluid to the confluence, wherein a flow of fluid through the second tubing section is controlled by the second roller pump;
a third tubing section fluidly connecting the confluence to an exit port;
a fourth tubing section fluidly connecting the third tubing section or a portion thereof to a waste receptacle; and
a waste by-pass tubing section fluidly connecting an upstream portion of the fourth tubing section with a downstream portion of the fourth tubing section, wherein a flow of fluid through the waste by-pass tubing section is controlled by the second roller pump.
2. The device of claim 1 , further comprising a delivery tubing section for delivering fluid to a patient, wherein the delivery tubing section is reversibly connected to the exit port.
3. The device of claim 1 , wherein the two or more roller pumps further comprise a third roller pump configured to control a flow of fluid through the fourth tubing section.
4. The device of claim 3 , further comprising a medical fluid by-pass tubing section fluidly connecting an upstream portion of the second tubing section to a downstream portion of the second tubing section.
5. The device of claim 4 , wherein a flow of fluid through the medical fluid by-pass tubing section is controlled by the third roller pump.
6. The device of claim 5 , wherein operating the third roller pump causes fluid to flow from the source of medical fluid through the medical fluid by-pass tubing section to the confluence, and into the third tubing section to the exit port.
7. The device of claim 4 , wherein the medical fluid by-pass tubing section is fluidly connected to the upstream portion of the second tubing section by a first T-joint, and the medical fluid by-pass tubing section is fluidly connected to the downstream portion of the second tubing section by a second T-joint.
8. The device of claim 4 , wherein the medical fluid by-pass tubing section is fluidly connected to the confluence.
9. The device of claim 1 , wherein a first T-joint connects the third tubing section to the fourth tubing section.
10. The device of claim 1 , wherein the waste by-pass tubing section is fluidly connected to the upstream portion of the fourth tubing section by a first T-joint, and the waste by-pass tubing section is fluidly connected to the downstream portion of the fourth tubing section by a second T-joint.
11. The device of claim 1 , wherein fluid from the source of medical fluid can flow through the second tubing section, the confluence, the third tubing section, and into the waste receptacle through the waste by-pass tubing section.
12. The device of claim 1 , further comprising an activity measuring device disposed between a first portion of the third tubing section and a second portion of the third tubing section.
13. The device of claim 12 , wherein the activity measuring device comprises a measurement coil.
14. The device of claim 12 , wherein the activity measuring device measures radioactivity.
15. The device of claim 1 , further comprising one or more check valves.
16. The device of claim 1 , wherein the confluence comprises one or more check valves.