Thawing vessel for biological products
Described herein are devices and methods for thawing frozen biological products efficiently without harming the products.
1. An apparatus for thawing a frozen biological material, the apparatus comprising:
a vessel having a biological material in an interior space of the vessel, the vessel having an upper portion extending around an upper portion of the interior space, a middle portion extending around a middle portion of the interior space and comprising an upper middle portion and a lower middle portion, and a lower portion extending around a lower portion of the interior space;
a plurality of thermal transfer devices operatively associated with the vessel for transferring heat between the vessel and the thermal transfer device, comprising at least:
a first thermal transfer device operatively associated with the upper portion of the vessel for transferring heat between the upper portion of the vessel and the first thermal transfer device;
a second thermal transfer device operatively associated with the upper middle portion of the vessel for transferring heat between the upper middle portion of the vessel and the second thermal transfer device;
a third thermal transfer device operatively associated with the lower middle portion of the vessel for transferring heat between the lower middle portion of the vessel and the third thermal transfer device; and
a fourth thermal transfer device operatively associated with the lower portion of the vessel for transferring heat between the lower portion of the vessel and the fourth thermal transfer device; and
at least one controller operatively associated with the first, second, third, and fourth thermal transfer devices for controlling the first, second, third, and fourth thermal transfer devices independently from one another, comprising the at least one controller being adapted for
controlling the first thermal transfer device to control thermal transfer between the first thermal transfer device and the upper portion of the vessel;
controlling the second thermal transfer device to control thermal transfer between the second thermal transfer device and the upper middle portion of the vessel;
controlling the third thermal transfer device to control thermal transfer between the third thermal transfer device and the lower middle portion of the vessel; and
controlling the fourth thermal transfer device to control thermal transfer between the fourth thermal transfer device and the lower portion of the vessel.
2. The apparatus of claim 1 , further comprising at least one stirring apparatus and thermocouples extending into the interior space of the vessel, wherein:
the thermocouples are arranged in an upwardly extending series;
the thermocouples are operatively associated with the at least one controller; and
the at least one controller is operative for controlling the first, second, third, and fourth thermal transfer devices at least partially in response to signals from the thermocouples.
3. The apparatus of claim 1 , wherein the at least one controller comprises at least one processor and at least one memory including computer program code, and the at least one memory and the computer program code are configured to, with the processor, provide signals for:
controlling the first, second, third, and fourth thermal transfer devices independently from one another; and
controlling the first thermal transfer device to control thermal transfer between the first thermal transfer device and the upper portion of the vessel;
controlling the second thermal transfer device to control thermal transfer between the second thermal transfer device and the upper middle portion of the vessel;
controlling the third thermal transfer device to control thermal transfer between the third thermal transfer device and the lower middle portion of the vessel; and
controlling the fourth thermal transfer device to control thermal transfer between the fourth thermal transfer device and the lower portion of the vessel.
4. The apparatus of claim 1 , wherein each of the first, second, third, and fourth thermal transfer devices comprises a jacket mounted to an exterior of the vessel for providing at least conductive thermal transfer between the jacket and the vessel.
5. The apparatus of claim 4 , wherein the jacket extends around the vessel.
6. The apparatus of claim 4 , wherein the jacket comprises at least one passageway for having a thermal transfer medium flow therethrough.
7. The apparatus of claim 6 , wherein the thermal transfer medium comprises a thermal transfer liquid.
8. The apparatus of claim 6 , comprising a system in fluid communication with the at least one passageway for circulating the thermal transfer medium through the passageway.