6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection

Inventors: Lei Guo (Shanghai, CN); Taishan Hu (Shanghai, CN); Yimin Hu (Shanghai, CN); Buelent Kocer (Steinen, DE); Xianfeng Lin (Shanghai, CN); Haixia Liu (Shanghai, CN); Alexander V Mayweg (Basel, CH); Zongxing Qiu (Shanghai, CN); Hong Shen (Shanghai, CN); Guozhi Tang (Shanghai, CN); Lisha Wang (Basel, CH); Guolong Wu (Shanghai, CN); Shixiang Yan (Shanghai, CN); Weixing Zhang (Shanghai, CN); Mingwei Zhou (Shanghai, CN); Wei Zhu (Shanghai, CN)

Assignee: Hoffmann-LA Roche INC.

C07D417/14 A61K31/506 A61K31/5377 A61K31/541 C07D401/14

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Quick Facts

Patent No.: US 9,447,086
App. No.: 14/022,519
Granted: Sep 20, 2016
Kind: B2

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Abstract

The invention provides novel compounds having the general formula: wherein R 1 , R 2 , R 3 , R 4 and A are as described herein, compositions including the compounds and methods of using the compounds.

Claims (5)

1. A compound selected from

2. A pharmaceutical composition comprising a compound in accordance with claim 1 and a therapeutically inert carrier.

3. A method of inhibiting hepatitis B virus in a human, which method comprises administering an effective amount to said human of a compound as defined in claim 1 .

4. A method for the treatment of hepatitis B virus infection in a human, which method comprises administering an effective amount to said human of a compound as defined in claim 1 .

5. A method for the treatment of hepatitis B virus infection in a human, which method comprises administering an effective amount to said human of a compound as defined in claim 1 together with an agent selected from the group consisting of interferon, pegylated interferons, Lamivudine, Adefovir dipivoxil, Entecavir, Telbivudine, and Tenofovir disoproxil.

Assignments (12)