Bendamustine derivatives and methods of using same
The present invention is directed to bendamustine esters and bendamustine amides and their use for the treatment of cancer.
1. A compound of formula (I),
wherein R 1 is C 8 -C 24 alkyl, or a pharmaceutically acceptable salt thereof.
2. The compound according to claim 1 , wherein R 1 is C 10 -C 24 alkyl, or a pharmaceutically acceptable salt thereof.
3. The compound according to claim 2 , wherein R 1 is C 12 -C 24 alkyl, or a pharmaceutically acceptable salt thereof.
4. The compound according to claim 3 , wherein R 1 is C 14 -C 24 alkyl, or a pharmaceutically acceptable salt thereof.
5. The compound according to claim 4 , wherein R 1 is C 16 -C 24 alkyl, or a pharmaceutically acceptable salt thereof.
6. The compound according to claim 5 , wherein R 1 is C 18 -C 24 alkyl, or a pharmaceutically acceptable salt thereof.
7. The compound according to claim 1 , wherein R 1 is C 10 alkyl, or a pharmaceutically acceptable salt thereof.
8. The compound according to claim 1 , wherein R 1 is C 14 alkyl, or a pharmaceutically acceptable salt thereof.
9. The compound according to claim 1 , wherein R 1 is C 15 alkyl, or a pharmaceutically acceptable salt thereof.
10. The compound according to claim 1 , wherein R 1 is C 16 alkyl, or a pharmaceutically acceptable salt thereof.
11. The compound according to claim 1 , wherein R 1 is C 18 alkyl, or a pharmaceutically acceptable salt thereof.
12. A pharmaceutical composition, comprising a compound of formula (I)
wherein R 1 is C 8 -C 24 alkyl, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
13. The pharmaceutical composition according to claim 12 , wherein said pharmaceutically acceptable carrier comprises albumin.
14. The pharmaceutical composition according to claim 13 , wherein said compound of formula (I) and said albumin are formulated as nanoparticles.
15. The pharmaceutical composition according to claim 14 , wherein said nanoparticles have an average particle size of about 248 nm or less.
16. The pharmaceutical composition according to claim 13 , wherein the weight-to-weight ratio of said albumin to said compound of formula (I), or a pharmaceutically acceptable salt thereof, is from about 2 to about 4.
17. The pharmaceutical composition according to claim 13 , wherein said albumin is human serum albumin.
18. The pharmaceutical composition according to claim 12 , wherein said pharmaceutical composition is in a solid form.
19. The pharmaceutical composition according to claim 12 , wherein said pharmaceutical composition is in a liquid form.
20. The pharmaceutical composition according to claim 19 , wherein said pharmaceutical composition is in a form suitable for intravenous administration to a patient in need thereof.
21. A method of treating cancer in a patient, comprising administering to said patient a pharmaceutical composition comprising a compound of formula (I),
wherein R 1 is C 8 -C 24 alkyl, or a pharmaceutically acceptable salt thereof, and a carrier.
22. The method according to claim 21 , wherein said cancer is in the form of a solid tumor.
23. The method according to claim 22 , wherein said cancer is sarcoma, bladder cancer, cervical cancer, testicular cancer, melanoma, glioblastoma, colon cancer, head and neck cancer, ovarian cancer, prostate cancer, breast cancer, or lung cancer.
24. The method according to claim 21 , wherein said cancer is in the form of a liquid tumor.
25. The method according to claim 24 , wherein said cancer is lymphocytic leukemia, Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, or acute lymphocytic leukemia.