Method for using a
The present invention relates to a method for enhancing the health of a human comprising administering to the human an effective amount of a composition comprising Bacillus subtilis QST713 or a mutant thereof.
1. A method for enhancing the health of a human suffering from a gastrointestinal disorder associated with a Campylobacter jejuni infection comprising:
administering to the human an effective amount of a composition comprising Bacillus subtilis QST713 (NRRL Accession Number B21661) or a mutant of Bacillus subtilis QST713
wherein
the mutant has DNA sequence identity to Bacillus subtilis QST713 of at least about 98%;
the effective amount is at least 1.5×10 8 colony forming units (CFU) per kg; and
administering the composition reduces or alleviates at least one symptom of the gastro-intestinal disorder associated with the Campylobacter jejuni infection.
2. The method of claim 1 wherein the composition comprises the Bacillus subtilis QST713.
3. The method of claim 2 wherein the composition further comprises metabolites produced by the Bacillus subtilis QST713.
4. The method of claim 1 wherein the symptom is diarrhea.
5. The method of claim 1 wherein the symptom is abdominal cramping.
6. The method of claim 1 wherein the symptom is inflammation of the gastrointestinal tract.
7. The method of claim 1 wherein the gastro-intestinal disorder is selected from the group consisting of acute diarrhea, inflammatory bowel disease, irritable bowel disorder, and antibiotic-associated diarrhea.
8. The method of claim 1 wherein the composition is administered in an amount effective to maintain healthy gut microflora.
9. The method of claim 1 wherein the composition further comprises a carrier.
10. The method of claim 1 wherein the composition is administered with other probiotics.
11. The method of claim 10 wherein the other probiotic is Saccharomyces boulardii.
12. The method of claim 1 wherein the composition is administered with a drug used to prevent or treat gastro-intestinal disorders.
13. The method of claim 12 wherein the drug is an antibiotic or an anti-inflammatory.
14. The method of claim 13 wherein the composition is administered after completion of administration of the antibiotic.
15. The method of claim 1 wherein the effective amount is at least 1.5×10 9 CFU per kg.