Labeled molecular imaging agents and methods of use
Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.
1. An imaging agent comprising a compound of Formula I
wherein R is H or C 1 -C 5 alkyl;
Y is acyl or sulfonyl;
A=null, —O—CH 2 —, —C 2 H 4 —, or —CH 2 —O—
Ar=4-substituted phenyl, a 4-substituted naphthalene-1-yl, a 5-substituted naphthalene-1-yl, or a 6-substituted naphthalene-1-yl;
X is 18 F, 3 H, —(CH 2 ) m Z, or —O—(CH 2 ) m Z,
Z is 18 F or 3 H;
n is an integer between 1 and 3; and
m is an integer between 1 and 5.
2. The agent of claim 1 wherein Y is acyl.
3. The agent of claim 2 wherein Z is 18 F or 3 H.
4. The agent of claim 3 wherein Z is a singularly occurring 18 F.
5. The agent of claim 1 wherein Formula I is
6. The agent of claim 1 wherein Formula I is
7. The agent of claim 1 wherein Formula I is
8. The agent of claim 1 wherein Formula I is