Labeled molecular imaging agents and methods of use
Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.
1. An imaging agent comprising a compound of Formula I
wherein X is 18 F, 3 H, —(CH 2 ) m Z, —CH 2 —O—(CH 2 ) m Z, or —O—(CH 2 ) m Z;
Z is 18 F or 3 H;
m is an integer between 1 and 5;
Y is O—CH 2 , CH 2 —O, CH 2 —CH 2 , CH 2 —CH 2 —CH 2 , O—CH 2 —CH 2 , or CH 2 —O—CH 2 ; and
Ar is a 3-substituted phenyl, 4-substituted phenyl, 4-substituted naphthalene-1-yl, 5-substituted naphthalene-1-yl, or 6-substituted naphthalene-2-yl.
2. The agent of claim 1 wherein X is —O—(CH 2 ) m Z.
3. The agent of claim 2 wherein Z is 18 F or 3 H.
4. The agent of claim 3 wherein Z is a singularly occurring 18 F.
5. The agent of claim 1 wherein Formula I is
6. The agent of claim 1 wherein Formula I is
7. The agent of claim 1 wherein Formula I is