Acid-solubilized copper-ammonium complexes and copper-zinc-ammonium complexes, compositions, preparations, methods, and uses
View Patent ↗An antimicrobial composition is disclosed that contains an acid-solubilized copper ammonium or copper-zinc ammonium complex that is effective against microorganisms such as nosocomial or environmental bacteria, fungi, viruses, and the like. The antimicrobial composition can be used in the preparation of a medicament for treating microbes or a microbial infection, and may contain a carrier to create a cream, soap, wash, spray, dressing, cleanser, cosmetic product, topical drug product, or other antimicrobial product.
1. An antimicrobial soluble copper composition comprising:
a solution comprising 10-160 grams/liter hydrated copper sulfate;
a basic ammonium salt added to the hydrated copper sulfate solution at 15-60 grams/liter to generate an insoluble copper-ammonium complex; and
at least one water soluble acid selected from the group consisting of phosphorous acid and phosphoric acid added to the hydrated copper sulfate solution to solubilize the copper-ammonium complex and to control the pH of the clear blue acid-solubilized copper-ammonium solution thus formed;
wherein when present the amount of phosphorous acid is 24-80 grams/liter and wherein when present the amount of phosphoric acid is 17-85 grams/liter;
the resulting composition having synergistic antimicrobial properties greater than the antimicrobial properties of each constituent component.
2. The antimicrobial composition of claim 1 , wherein the basic ammonium salt is selected from the group consisting of ammonium hydroxide, ammonium carbonate, and ammonium hydrogen carbonate.
3. The antimicrobial composition of claim 1 , wherein the water is selected from the group consisting of distilled water, deionized water, purified water, filtered water, pharmaceutical grade water, medical grade water, and reverse osmosis water.
4. The antimicrobial composition of claim 1 wherein the hydrated copper sulfate solution further comprises 11-66 grams/liter of a zinc salt in solution forming a copper-zinc-ammonium complex upon the addition of the basic ammonium salt.
5. The antimicrobial composition of claim 4 wherein the zinc salt is selected from the group consisting of anhydrous zinc sulfate, anhydrous zinc chloride, hydrated zinc sulfate, and hydrated zinc chloride.
6. The antimicrobial composition of claim 4 wherein the ammonium salt is dissolved in water.
7. The antimicrobial composition of claim 1 further comprising a carrier selected from the group consisting of a gel, an ointment, an oil, a paste, a medicament, a sprayable solution, a dressing solution, an irrigation solution, a cream, a soap, a detergent, a wash, and a foam.
8. The antimicrobial composition of claim 1 , wherein said antimicrobial composition is a plant protection product.
9. An antimicrobial composition produced by the process of:
combining 10-160 grams/liter of hydrated copper sulfate with water;
stirring the combined hydrated copper sulfate and water mixture;
adding 15-60 grams/liter of a basic ammonium salt to the resulting mixture to generate an insoluble copper-ammonium complex; and
adding a water soluble acid selected from the group consisting of phosphorous acid and phosphoric acid to the copper-ammonium complex to solubilize the copper-ammonium complex and to control the pH of the clear blue solution thus formed;
wherein when present the amount of phosphorous acid is 24-80 grams/liter and wherein when present the amount of phosphoric acid is 17-85 grams/liter,
the resulting composition having synergistic antimicrobial properties greater than the antimicrobial properties of each constituent component.
10. The antimicrobial composition of claim 9 , wherein the water is selected from the group consisting of distilled water, deionized water, purified water, filtered water, pharmaceutical grade water, medical grade water, and reverse osmosis water.
11. The antimicrobial composition of claim 9 wherein the basic ammonium salt is selected from the group consisting of ammonium hydroxide, ammonium carbonate, and ammonium hydrogen carbonate.
12. The antimicrobial composition of claim 11 wherein the hydrated copper sulfate solution further comprises 11-66 grams/liter of a zinc salt in solution forming a copper-zinc-ammonium complex upon the addition of the ammonium hydroxide, ammonium carbonate or ammonium hydrogen carbonate.
13. The antimicrobial composition of claim 9 wherein the zinc salt is selected from the group consisting of anhydrous zinc sulfate, anhydrous zinc chloride, hydrated zinc sulfate, and hydrated zinc chloride.
14. The antimicrobial composition of claim 9 wherein the basic ammonium salt is dissolved in water before being combined with the hydrated copper sulfate and water mixture.
15. The antimicrobial composition of claim 9 further comprising a carrier selected from the group consisting of a gel, an ointment, an oil, a paste, a medicament, a sprayable solution, a dressing solution, an irrigation solution, a cream, a soap, a detergent, a wash, and a foam.
16. A method of producing an antimicrobial composition comprising the steps of:
combining 10-160 grams/liter of hydrated copper sulfate with water;
stirring the combined hydrated copper sulfate and water mixture;
adding 15-60 grams/liter of a basic ammonium salt to the resulting mixture to generate an insoluble copper-ammonium complex; and
adding a water soluble acid selected from the group consisting of phosphorous acid and phosphoric acid to the copper-ammonium complex to solubilize the copper-ammonium complex and to control the pH of the clear blue antimicrobial composition thus formed;
wherein when present the amount of phosphorous acid is 24-80 grams/liter and wherein when present the amount of phosphoric acid is 17-85 grams/liter;
the resulting composition having synergistic antimicrobial properties greater than the antimicrobial properties of each constituent component.