Method for making bismuth containing liquid pharmaceutical suspensions
A method of producing a liquid pharmaceutical suspension by mixing magnesium aluminum silicate, gellan gum, bismuth subsalicylate, and methyl cellulose.
1. A method of making a liquid pharmaceutical suspension comprising:
a. mixing magnesium aluminum silicate with an aqueous media to form a first mixture;
b. mixing from about 0.001% to about 0.1% gellan gum with the first mixture to form a second mixture;
c. mixing a bismuth slurry with the second mixture to form a third mixture;
d. mixing methyl cellulose with the third mixture to form a liquid pharmaceutical suspension.
2. The method of claim 1 wherein the bismuth slurry comprises from about 5% to about 40% bismuth subsalicylate.
3. The method of claim 1 wherein the bismuth slurry comprises bismuth subsalicylate particles with an average diameter from about 0.5 μm to about 100 μm.
4. The method of claim 1 wherein the method is performed at ambient temperature.
5. A method of making a suspension comprising:
a. adding a suspension system component to an aqueous media to form a first mixture utilizing a hopper for containing the suspension system component, the hopper having a hopper inlet for receiving the suspension system component and a throat for distributing the suspension system component; the throat comprises a throat inlet for receiving solids from the hopper and a throat outlet for discharging solids from the throat wherein a vertically oriented auger is disposed in the throat wherein the throat outlet is connected to a disperser at a connection and wherein the connection is substantially free of air; and
b. adding an internal phase to form a suspension;
wherein the suspension system component comprises from about 0.001% to about 0.1% gellan gum and wherein the gellan gum is a powder.
6. The method of claim 5 wherein the internal phase comprises a bismuth slurry comprising from about 7% to about 30% bismuth subsalicylate.
7. The method of claim 5 wherein the suspension system component comprises magnesium aluminum silicate and wherein the magnesium aluminum silicate is a powder.
8. The method claim 5 wherein the suspension system component comprises methyl cellulose and wherein the methyl cellulose is a powder.
9. A method of producing a suspension comprising: adding from about 0.001% to about 0.1% gellan gum to an ionic solution at ambient temperature; and adding a bismuth slurry comprising from about 7% to about 30% bismuth subsalicylate.
10. The method of claim 9 comprising from about 0.005% to about 0.06% gellan gum; wherein the liquid pharmaceutical suspension comprises gellan gum aggregates with an average length from about 50 μm to about 2000 μm.
11. The method of claim 1 comprising from about 0.01% to about 0.05% gellan gum.
12. The method of claim 1 comprising from about 0.01% to about 0.5% magnesium aluminum silicate.
13. The method of claim 1 comprising from about 0.1% to about 5% methyl cellulose.
14. The method of claim 1 comprising from about 0.02% to about 0.04% gellan gum.
15. The method of claim 7 comprising from about 0.01% to about 0.5% magnesium aluminum silicate.
16. The method of claim 9 comprising from about 0.01% to about 0.05% gellan gum.
17. The method of claim 9 further comprising adding methyl cellulose.
18. The method of claim 9 comprising adding from about 0.1% to about 5% methyl cellulose.