Anti periodontitis-causing microorganism agent and medical or dental materials using the same
A medical or dental material can be prepared by using, as an active ingredient, at least one of a protamine, and derivatives thereof and hydrolysates thereof, or a complex of at least one of a protamine, and derivatives thereof and hydrolysates thereof with an anionic high molecular weight compound. As a result, an antibacterial agent against periodontal disease-causing bacteria can be provided, which is highly safe without concern of a side effect. A medical or dental material can be also provided, which exhibits antimicrobial activity on periodontal disease-causing bacteria and additionally has insolubility in water and good formability.
1. A medical or dental material for osteogenesis, in the form of paste, which comprises a complex of a protamine with a DNA electrostatically bound with the protamine,
wherein the medical or dental material has antimicrobial activity, insolubility in water and formability for guiding or promoting osteogenesis, and
wherein the DNA has a molecular weight between 300 bp and 7,000 bp.
2. A medical or dental material according to claim 1 , wherein the complex includes calcium phosphate.
3. A medical or dental material according to claim 1 , which carries a bone morphogenetic protein or a growth factor.
4. A medical or dental material according to claim 1 , which has formability to fill a bone defect as a bone filling material for guiding or promoting osteogenesis.
5. A medical or dental material according to claim 1 , which is molded to form a membrane for guiding paradentium regeneration or to form a shape selected from the group consisting of a string, a rod, a spherical and a disk for guiding osteogenesis.