System and method for attaching soft tissue to an implant comprising a nanotextured surface
One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein the porous region exhibits a nano-textured surface, and a biocompatible polymer matrix coating the nano-textured surface. The polymer matrix coating comprises a naturally occurring extracellular matrix with biocompatible inorganic materials distributed within the matrix, or a biocompatible polymer and an osteo-inductive agent.
1. A kit for repairing a diarthrodial joint, the kit comprising:
a metal implant construct, the construct comprising
a metal implant comprising a porous region, wherein the porous region exhibits a nano-textured surface;
a calcified material layer coating the nano-textured surface;
an extender graft comprising a naturally occurring extracellular matrix, and a mesh member coupled to the naturally occurring extracellular matrix; and
a scaffold element, wherein the scaffold element comprises a biocompatible polymer matrix and a bioactive agent.
2. The kit of claim 1 wherein the scaffold element comprises a submucosal matrix.
3. The kit of claim 1 wherein the calcified material layer consists essentially of nano-scale hydroxyapatite particles.
4. A kit for repairing a diarthrodial joint, the kit comprising:
a metal implant construct, the construct comprising
a metal implant comprising a porous region, wherein the porous region exhibits a nano-textured surface; and
a calcified material layer coating the nano-textured surface; and
an extender graft comprising a naturally occurring extracellular matrix, and a mesh member coupled to the naturally occurring extracellular matrix, wherein the calcified material layer comprises a naturally occurring extracellular matrix and exogenously added biocompatible inorganic material.
5. The kit of claim 4 wherein the naturally occurring extracellular matrix includes intestinal submucosa that is prepared as a gel, with the biocompatible inorganic material dispersed within the naturally occurring extracellular matrix.
6. The kit of claim 5 wherein the biocompatible inorganic material comprises nano-scale hydroxyapatite crystals.
7. A method of attaching soft tissue to a metal implant, the method comprising the steps of
providing a metal implant construct, the construct comprising
a metal implant comprising a porous region, wherein the porous region exhibits a nano-textured surface; and
a biocompatible polymer matrix coating the nano-textured surface, wherein the biocompatible polymer matrix comprises a naturally occurring extracellular matrix and an exogenously added biocompatible inorganic material;
coupling at least a portion of a scaffold layer to the metal implant and in contact with the biocompatible polymer matrix, wherein the scaffold layer comprises a biocompatible polymer matrix and a growth factor;
attaching a proximal end of an extender portion to the scaffold layer, wherein the extender portion comprises a submucosal matrix, and a synthetic portion coupled to the submucosal matrix, the synthetic portion including a mesh member wherein the mesh member is coated with a naturally occurring extracellular matrix; and
attaching a distal end of the extender portion to a patient's soft tissue.