Stimulation of the urinary system
Apparatus and methods are provided, including a bladder stimulator that includes an elongate element adapted to pass through a urethra or adapted to pass through another opening in the bladder, an expandable body coupled to said elongate element, and an array of one or more stimulator contacts coupled to the expandable body, the array including at least one contact adapted to contact a portion of a bladder of a subject when the expandable body is inserted in the bladder and expanded. A controller stimulates the portion of the bladder by driving a pulse into the bladder via the contact, the pulse having a frequency of 5 Hz-1 kHz. Other applications are also described.
1. Apparatus for use with a subject who has a bladder, the apparatus comprising:
a bladder stimulator that comprises:
an elongate element adapted to pass through an opening selected from the group consisting of: a urethra of the subject, and an opening in the subject's bladder other than the subject's urethra;
an expandable body coupled to the elongate element;
an array of one or more stimulator contacts coupled to the expandable body, the one or more stimulator contacts adapted to contact a portion of a body of the subject when the expandable body is inserted in the bladder and expanded, the portion of the subject's body being selected from the group consisting of: a distal area of a ureter of the subject, and a portion of the subject's bladder; and
a controller configured to stimulate the selected portion of the subject's body, by driving an electrical pulse into the selected portion via the one or more stimulator contacts, the electrical pulse having a frequency of 5 Hz-1 kHz,
the controller, by driving the electrical pulse into the selected portion of the subject's body, being configured to cause a therapeutic change in a value of at least one parameter, relative to a value of the parameter in an absence of the electrical pulse being driven into the selected portion of the subject's body, the parameter being selected from the group consisting of: glomerular filtration rate, renal sympathetic activity, renal blood flow, diuresis, and natriuresis.
2. The apparatus according to claim 1 , wherein the array of one or more stimulator contacts:
includes fewer than 10 stimulator contacts, and
covers one hemisphere or less of the expandable body.
3. The apparatus according to claim 1 ,
wherein the controller comprises a feedback circuit configured to sense a parameter selected from the group consisting of: a physiological effect of driving the electrical pulse into the selected portion of the subject's body, and a quality of contact between the one or more stimulator contacts and tissue of the selected portion of the subject's body, and
wherein the controller is configured to stimulate the selected portion of the subject's body based upon the sensed parameter.
4. The apparatus according to claim 3 , wherein the feedback circuit is configured to sense a parameter selected from the group consisting of: bladder volume and bladder pressure of the subject's bladder.
5. The apparatus according to claim 1 , wherein the elongate element comprises a tube that defines a lumen, the lumen being adapted to substantially evacuate the subject's bladder by allowing urine flow therethrough.
6. The apparatus according to claim 5 , wherein the controller is configured to measure the urine flow through the elongate element.
7. The apparatus according to claim 1 , further comprising one or more urethral stimulator contacts adapted to contact a portion of a urethra of the subject, wherein the controller is configured to stimulate the urethra by driving a urethral electrical pulse into the urethra via the one or more urethral stimulator contacts.
8. The apparatus according to claim 7 , wherein the controller is configured to stimulate the urethra by driving the urethral electrical pulse into the urethra, via the one or more urethral stimulator contacts, the urethral electrical pulse having a frequency of 5 Hz-1 kHz.
9. The apparatus according to claim 1 , wherein the expandable body is not a balloon.
10. The apparatus according to claim 9 , wherein the expandable body comprises extendible arms.
11. The apparatus according to claim 1 , wherein the stimulator is configured to remain in the subject's body for more than two hours.
12. The apparatus according to claim 11 , wherein the stimulator is configured to remain in the subject's body for more than three days.
13. Apparatus for use with a subject who has a bladder, the apparatus comprising:
a bladder stimulator that comprises:
an elongate element adapted to pass through an opening selected from the group consisting of: a urethra of the subject, and an opening in the subject's bladder other than the subject's urethra;
an expandable body coupled to the elongate element;
an array of one or more stimulator contacts coupled to the expandable body, the one or more stimulator contacts adapted to contact a portion of a body of the subject when the expandable body is inserted in the bladder and expanded, the portion of the subject's body being selected from the group consisting of: a distal area of a ureter of the subject, and a portion of the subject's bladder; and
a controller configured to stimulate the selected portion of the subject's body, by driving an electrical pulse into the selected portion via the one or more stimulator contacts, the electrical pulse having a frequency of 5 Hz 1 kHz,
the controller comprising a feedback circuit configured to sense electrical activity of tissue in the vicinity of the contacts, the feedback circuit being configured to sense a parameter selected from the group consisting of: a physiological effect of driving the electrical pulse into the selected portion of the subject's body, and a quality of contact between the one or more stimulator contacts and tissue of the selected portion of the subject's body, and
the controller being configured to stimulate the selected portion of the subject's body based upon the sensed parameter.
14. Apparatus for use with a subject, the apparatus comprising:
an electrical stimulator that comprises:
one or more stimulator contacts adapted to contact a portion of a body of the subject selected from the group consisting of: a ureter, a trigone, a uretero-vesical junction, a urethra, a renal pelvis, an internal structure of the kidney, a lumen in the kidney, and a bladder; and
a controller configured to:
stimulate the selected portion of the subject's body, by driving an electrical pulse into the selected portion, via the one or more stimulator contacts, and
cause a therapeutic change in a value of at least one parameter, relative to a value of the parameter in an absence of the electrical stimulation being applied to the selected portion, the parameter being selected from the group consisting of: glomerular filtration rate, blood pressure, systemic sympathetic activity, renal sympathetic activity, renal blood flow, diuresis, and natriuresis, by configuring the electrical pulse to have a frequency of 5 Hz-1 kHz.
15. The apparatus according to claim 14 , wherein the one or more stimulator contacts are configured to be implanted in contact with the subject's ureter, and wherein the controller is configured to stimulate the subject's ureter by driving an electrical pulse into the subject's ureter via the one or more stimulator contacts.
16. The apparatus according to claim 14 , wherein the one or more stimulator contacts are configured to be implanted in contact with the subject's renal pelvis, and wherein the controller is configured to stimulate the subject's renal pelvis by driving an electrical pulse into the subject's renal pelvis via the one or more stimulator contacts.
17. The apparatus according to claim 14 ,
wherein the controller comprises a feedback circuit configured to sense a parameter selected from the group consisting of: a physiological effect of driving the electrical pulse into the selected portion of the subject's body, and a quality of contact between the one or more stimulator contacts and tissue of the selected portion of the subject's body, and
wherein the controller is configured to stimulate the selected portion of the subject's body responsively to the sensed parameter.
18. The apparatus according to claim 14 , wherein the stimulator is configured to remain within the subject's body for more than two hours.
19. The apparatus according to claim 14 , wherein the stimulator is configured to remain within the subject's body for more than three days.
20. The apparatus according to claim 14 , wherein the stimulator is configured to remain within the subject's body for at least two weeks.
21. The apparatus according to claim 14 , wherein, by driving the pulse into the selected portion, the controller is configured to stimulate an afferent nerve of the subject.
22. The apparatus according to claim 14 , wherein, by driving the pulse into the selected portion, the controller is configured to modify a sensitivity of a portion of the subject's body selected from the group consisting of: a sensory receptor and a nerve pathway of a sensory receptor.
23. Apparatus for use with a subject who has a urethra, the apparatus comprising:
a urethral stimulator that comprises:
an elongate element adapted to pass through the subject's urethra;
one or more stimulator contacts coupled to the elongate element and adapted to contact a portion of the urethra; and
a controller configured to stimulate the urethra by driving an electrical pulse into the urethra via the one or more stimulator contacts, the electrical pulse having a frequency of 5 Hz-1 kHz,
the controller, by driving the electrical pulse into the urethra, being configured to cause a therapeutic change in a value of at least one parameter, relative to a value of the parameter in an absence of the electrical pulse being driven into the urethra, the parameter being selected from the group consisting of: glomerular filtration rate, renal sympathetic activity, renal blood flow, diuresis, and natriuresis.
24. The apparatus according to claim 23 ,
wherein the controller comprises a feedback circuit configured to sense a parameter selected from the group consisting of: a physiological effect of driving the pulse into the urethra, and a quality of contact between the one or more stimulator contacts and tissue of the subject's urethra, and
wherein the controller is configured to stimulate the subject's urethra responsively to the sensed parameter.
25. The apparatus according to claim 24 , wherein the feedback circuit is configured to sense a parameter selected from the group consisting of: bladder volume and bladder pressure of a bladder of the subject.
26. The apparatus according to claim 23 , wherein the elongate element is configured to remain in the subject's urethra for more than two hours.
27. The apparatus according to claim 26 , wherein the elongate element is configured to remain in the subject's urethra for more than three days.
28. The apparatus according to claim 23 , wherein the elongate element comprises a tube that defines a lumen, the lumen being adapted to substantially evacuate a bladder of the subject by allowing urine flow therethrough.
29. The apparatus according to claim 28 , wherein the controller is configured to measure the urine flow through the elongate element.
30. Apparatus for use with a subject who has a urethra, the apparatus comprising:
a urethral stimulator that comprises:
an elongate element adapted to pass through the subject's urethra;
one or more stimulator contacts coupled to the elongate element and adapted to contact a portion of the urethra; and
a controller configured to stimulate the urethra by driving an electrical pulse into the urethra via the one or more stimulator contacts, the electrical pulse having a frequency of 5 Hz-1 kHz,
the controller comprising a feedback circuit configured to sense electrical activity of tissue in the vicinity of the contacts, the feedback circuit being configured to sense a parameter selected from the group consisting of: a physiological effect of driving the pulse into the urethra, and a quality of contact between the one or more stimulator contacts and tissue of the subject's urethra, and
the controller being configured to stimulate the subject's urethra responsively to the sensed parameter.