Isolated compounds from turmeric oil and methods of use
Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods for treatment, inhibition, and/or abatement of cognitive decline and/or Alzheimer's disease with a compound or pharmaceutically acceptable salt of the invention are also provided. Also provided are methods of preparing the compounds/compositions of the invention.
1. A compound comprising formula I-0
or pharmaceutically acceptable salt thereof, wherein:
is selected from a single bond and a double bond;
R 1 is selected from F, Cl, Br, CF 3 , and OCF 3 ;
R 2 is selected from CH 2 C(CH 3 ) 2 OH and CH═C(CH 3 ) 2 ; and
R 3 is NHCH 2 CH(CH 3 ) 2 .
2. The compound of claim 1 , wherein R 2 is CH 2 C(CH 3 ) 2 OH.
3. A compound comprising formula I-1
or pharmaceutically acceptable salt thereof, wherein:
is selected from a single bond and a double bond;
R 1 is selected from F, Cl, Br, CF 3 , and OCF 3 ;
R 2 is selected from CH 2 C(CH 3 ) 2 OH and CH═C(CH 3 ) 2 ; and
R 3 is NHCH 2 CH(CH 3 ) 2 .
4. A compound comprising formula I-2
or pharmaceutically acceptable salt thereof, wherein:
is selected from a single bond and a double bond;
R 1 is selected from F, Cl, Br, CF 3 , and OCF 3 ;
R 2 is selected from CH 2 C(CH 3 ) 2 OH and CH═C(CH 3 ) 2 ; and
R 3 is NHCH 2 CH(CH 3 ) 2 .
5. The compound of claim 4 , wherein R 2 is CH 2 C(CH 3 ) 2 OH.
6. A pharmaceutical composition comprising a therapeutically effective amount of a compound of formula I-0
wherein:
is selected from a single bond and a double bond;
R 1 is selected from F, Cl, Br, CF 3 , and OCF 3 ;
R 2 is selected from CH 2 C(CH 3 ) 2 OH and CH═C(CH 3 ) 2 and
R 3 is NHCH 2 CH(CH 3 ) 2
or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.
7. A pharmaceutical composition comprising a therapeutically effective amount of a compound of formula I-1
wherein:
is selected from a single bond and a double bond;
R 1 is selected from F, Cl, Br, CF 3 , and OCF 3 ;
R 2 is selected from CH 2 C(CH 3 ) 2 OH and CH═C(CH 3 ) 2 ; and
R 3 is NH CH2 CH(CH3) 2
or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.
8. A pharmaceutical composition comprising a therapeutically effective amount of a compound of formula I-2
wherein:
is selected from a single bond and a double bond;
R 1 is selected from F, Cl, Br, CF 3 , and OCF 3 ;
R 2 is selected from CH 2 C(CH 3 ) 2 OH and CH═C(CH 3 ) 2 ; and
R 3 is NHCH 2 CH(CH 3 ) 2
or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.