Porous materials, methods of making and uses
The present specification discloses porous materials, methods of forming such porous materials, materials and devices comprising such porous materials, and methods of making such materials and devices.
1. A method for forming an elastic, porous structure suitable for implantation in a mammal, the method comprising the steps of:
a) coating porogens with a matrix material to form a matrix material-coated porogen mixture, wherein the matrix material is a poly(lactic-co-glycolic acid) (PLGA);
b) filtering the matrix material-coated porogen mixture through a sieve to remove excess matrix material;
c) pouring the filtered mixture into a mold;
d) treating the filtered mixture to form a scaffold comprising fused porogens and cured matrix material, wherein the scaffold comprises a three-dimensional structure in the form of the mold; and
e) removing the fused porogens from the scaffold, wherein fused porogen removal results in a porous material comprising the cured matrix material defining an array of interconnected pores.
2. The method of claim 1 , wherein in the scaffold comprises a three-dimensional structure wherein the diameter of substantially all the connections between each fused porogen in between about 15% to about 80% of the mean porogen diameter.
3. The method of claim 1 , wherein the cured matrix material exhibits an elastic elongation of at least 80%.
4. The method of claim 1 , wherein the matrix material is a silicone elastomer.
5. The method of claim 1 , wherein the porogens are porogens having a diameter of 50 μm to about 3000 μm.
6. The method of claim 1 , wherein the porogens are porogens having a diameter of about 500 μm.
7. The method of claim 1 , wherein the porogens are porogens having a diameter of about 650 μm.
8. A method for forming a tissue engineering scaffold suitable for implantation in a mammal, the method comprising the steps of:
a) coating porogens with a matrix material to form a matrix material-coated porogen mixture, wherein the porogens are porogens having a diameter of 50 μm to about 3000 μm;
b) filtering the matrix material-coated porogen mixture through a sieve to remove excess matrix material;
c) pouring the filtered mixture into a mold;
d) treating the filtered mixture to form a scaffold comprising fused porogens and cured matrix material, wherein the scaffold comprises a three-dimensional structure in the form of the mold; and
e) removing the fused porogens from the scaffold, wherein fused porogen removal results in a porous material comprising the cured matrix material defining an array of interconnected pores.
9. The method of claim 8 , wherein in the scaffold comprises a three-dimensional structure wherein the diameter of substantially all the connections between each fused porogen in between about 15% to about 80% of the mean porogen diameter.
10. The method of claim 8 , wherein the cured matrix material exhibits an elastic elongation of at least 80%.
11. The method of claim 8 , wherein the matrix material is a silicone elastomer.
12. The method of claim 8 , wherein the matrix material is a poly(lactic-co-glycolic acid) (PLGA).
13. The method of claim 8 , wherein the porogens are porogens having a diameter of about 500 μm.
14. The method of claim 8 , wherein the porogens are porogens having a diameter of about 650 μm.
15. A method for forming an elastic porous article for biomedical applications, the method comprising the steps of:
a) coating porogens with a matrix material to form a matrix material-coated porogen mixture, wherein the porogens are porogens having a diameter of 50 μm to about 3000 μm;
b) filtering the matrix material-coated porogen mixture through a sieve to remove excess matrix material;
c) pouring the filtered mixture into a mold;
d) treating the filtered mixture to form a scaffold comprising fused porogens and cured matrix material, wherein the scaffold comprises a three-dimensional structure in the form of the mold; and
e) removing the fused porogens from the scaffold, wherein fused porogen removal results in a porous material comprising the cured matrix material defining an array of interconnected pores.
16. The method of claim 15 , wherein the porous article is a membrane for filtration or separation.
17. The method of claim 15 , wherein the porous article is a wound dressing.
18. The method of claim 15 , wherein the porous article is a drug release matrix.