Influenza virus-neutralizing antibody and screening method therefor
Provided is an anti-influenza virus antibody that exhibits neutralizing activity beyond the barrier of the two groups of influenza viruses categorized according to the conservativeness of hemagglutinin amino acids, a method of producing the same, and a test method for determining whether the subject carries the neutralizing antibody.
1. An isolated antibody comprising a heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO:15 and a light chain variable region comprising the amino acid sequence set forth in SEQ ID NO:26, wherein the antibody binds influenza virus HA.
2. A pharmaceutical composition comprising:
a) an isolated antibody comprising a heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO:15 and a light chain variable region comprising the amino acid sequence set forth in SEQ ID NO:26, wherein the antibody binds influenza virus HA, and
b) a pharmacologically acceptable carrier.