Antibodies to tumor endothelial marker 7R
Antibodies that specifically bind to an epitope on the extracellular domain of TEM7R are provided. Nucleic acids encoding such antibodies and cells capable of expressing such antibodies are also provided. The antibodies may be used in methods for treating tumors and for inhibiting angiogenesis in tumors.
1. An isolated antibody, comprising a heavy chain variable region having the amino acid sequence of SEQ ID NO: 9 and a light chain variable region, wherein the antibody specifically binds to an epitope on the extracellular domain of TEM7R.
2. The antibody of claim 1 , wherein the light chain variable region comprises the amino acid sequence of SEQ ID NO: 10.
3. The antibody of claim 1 , wherein the antibody is a monoclonal antibody.
4. The antibody of claim 1 , wherein the antibody comprises a single chain Fv.
5. The antibody of claim 4 , wherein the single chain Fv comprises the amino acid sequence of SEQ ID NO: 11.
6. The antibody of claim 1 , wherein the antibody is a chimeric antibody.
7. The antibody of claim 1 , wherein the antibody is conjugated to a chemotherapeutic agent.
8. The antibody of claim 1 , wherein the antibody is conjugated to a detectable label.
9. The antibody of claim 1 , wherein the TEM7R is human TEM7R.
10. The antibody of claim 1 , wherein the TEM7R is mouse TEM7R.
11. A composition, comprising the antibody of claim 1 and a pharmaceutically acceptable carrier.
12. A composition, comprising the antibody of claim 7 and a pharmaceutically acceptable carrier.
13. An isolated antibody, comprising a. light chain variable region having the amino acid sequence of SEQ ID NO, 10and a heavy chain variable region, wherein the antibody specifically binds to an epitope on the extracellular domain of TEM7R.
14. The antibody of claim 13 , wherein the heavy chain variable region comprises the amino acid sequence of SEQ ID NO: 9.
15. The antibody of claim 13 , wherein the antibody is a monoclonal antibody.
16. The antibody of claim 13 , wherein the antibody comprises a single chain Fv.
17. The antibody of claim 16 , wherein the single chain Fv comprises the amino acid sequence of SEQ ID NO: 11.
18. The antibody of claim 13 , wherein the antibody is a chimeric antibody.
19. The antibody of claim 13 , wherein the antibody is conjugated to a chemotherapeutic agent.
20. The antibody of claim 13 , wherein the antibody is conjugated to a detectable label.
21. The antibody of claim 13 , wherein the TEM7R is human TEM7R.
22. The antibody of claim 13 , wherein the TEM7R is mouse TEM7R.
23. A composition, comprising the antibody of claim 13 and a pharmaceutically acceptable carrier.
24. A composition, comprising the antibody of claim 20 and a pharmaceutically acceptable carrier.