IP Library Granted Patent US 9,540,394
Granted Patent B2
US 9,540,394 · App. 14/881,595 · Granted Jan 10, 2017

Compounds and methods for treating bacterial infections

Inventors: Gregory Steven Basarab (Sudbury, MA); Madhusudhan Reddy Gowravaram (Acton, MA); Sheila Hauck (Lincoln, MA); Fei Zhou (Jamaica Plain, MA)
Assignee: Entasis Therapeutics Limited
C07D498/22
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Quick Facts
Patent No.
US 9,540,394
App. No.
14/881,595
Granted
Jan 10, 2017
Kind
B2
Abstract

Compounds of formula (I), pharmaceutically acceptable salts thereof, and uses of the compounds of formula (I) for treating bacterial infections are disclosed.

Claims (8)

1. A method for treating a Neisseria gonorrhoeae infection in a subject in need thereof comprising administering to the subject an effective amount of a compound according to the structure:

or a pharmaceutically acceptable salt thereof.

2. A method for treating pneumonia in a subject in need thereof, comprising administering to the subject an effective amount of a compound according to the structure:

or a pharmaceutically acceptable salt thereof.

3. A method for treating a Burkholderia spp. infection in a subject in need thereof comprising administering to the subject an effective amount of a compound according to the structure:

or a pharmaceutically acceptable salt thereof.

4. A method for treating a complicated skin and skin structure infection in a subject in need thereof comprising administering to the subject an effective amount of a compound according to the structure:

or a pharmaceutically acceptable salt thereof.

Assignments (5)
NUNC PRO TUNC ASSIGNMENT Recorded Feb 20, 2025
From: ENTASIS THERAPEUTICS LIMITED
To: ENTASIS THERAPEUTICS INC.
Reel/Frame 070271/0396 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 6, 2016
From: BASARAB, GREGORY STEVEN; GOWRAVARAM, MADHUSUDHAN REDDY; HAUCK, SHEILA; ZHOU, FEI
To: ASTRAZENECA PHARMACEUTICALS LP
Reel/Frame 039955/0636 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 6, 2016
From: ASTRAZENECA PHARMACEUTICALS LP
To: ASTRAZENECA UK LIMITED
Reel/Frame 039957/0666 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 6, 2016
From: ASTRAZENECA UK LIMITED
To: ASTRAZENECA AB
Reel/Frame 039957/0837 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 6, 2016
From: ASTRAZENECA AB
To: ENTASIS THERAPEUTICS LIMITED
Reel/Frame 039958/0106 →
Continuity (5)
Continuation 14515684 · Oct 16, 2014
Continuation 14159773 · Jan 21, 2014
Provisional Application 61859910 · Jul 30, 2013
Provisional Application 61755537 · Jan 23, 2013
Related Publication 20160130281A1 · May 12, 2016