Biomineral and metal binding liposomes, their synthesis, and methods of use thereof
View Patent ↗Drug carriers, methods of synthesizing, and methods of use thereof are provided. The drug carriers are liposomes comprising at least one functionalized cholesterol of the formula: Chol-X-T, wherein X is a linker domain, T is at least one targeting moiety which binds hard tissue and/or medical implants, and Chol is cholesterol or a derivative or analog thereof. The liposomes may encapsulate at least one therapeutic agent for the treatment of an oral disease or disorder.
1. A liposome comprising at least one functionalized cholesterol of the formula: Chol-X-T, wherein X is a linker domain, T is at least one targeting moiety which binds hard tissue and/or medical implants, and Chol is cholesterol or a derivative or analog thereof,
wherein said liposome encapsulates at least one therapeutic agent for the treatment of an oral disease or disorder, and
wherein said functionalized cholesterol has the formula:
wherein n is 0 to about 10.
2. The liposome of claim 1 , wherein said targeting moiety is selected from the group consisting of bisphosphonates, alendronate, tetracycline, tetracycline analogs, sialic acid, malonic acid, N,N-dicarboxymethylamine, 4-aminosalicyclic acid, 5-aminosalicyclic acid, antibodies or fragments or derivatives thereof specific for hard tissue or implant material, and peptides comprising about 2 to about 100 amino acids selected from the group consisting of D-glutamic acid, L-glutamic acid, D-aspartic acid, L-aspartic acid, D-phosphoserine, L-phosphoserine, D-phosphothreonine, L-phosphothreonine, D-phosphotyrosine, and L-phosphotyrosine.
3. The liposome of claim 2 , wherein said targeting moiety is alendronate.
4. The liposome of claim 1 , wherein said functionalized cholesterol has the formula:
wherein n is 0 to about 10; wherein m is 1 to about 10; and q is 1 to about 10.
5. The liposome of claim 1 , wherein said liposome further encapsulates at least one detectable agent.
6. The liposome of claim 1 , wherein said therapeutic agent comprises fluoride.
7. A composition comprising at least one liposome of claim 1 and at least one pharmaceutically acceptable carrier.
8. A method of inhibiting a bone related disease or disorder and/or oral disease or disorder, said method comprising administering the composition of claim 7 to a subject.
9. The liposome of claim 1 , wherein said therapeutic agent is selected from the group consisting of menthol, a fragrant agent, a flavoring agent, cooling agent, fluoride, vitamins, neutraceuticals, tooth whitening agents, tooth coloring agents, bleaching or oxidizing agents, thickening agents, and sweetening agents.