Chronic electroaccupuncture using implanted electrodes
Certain embodiments are directed to methods of treating a metabolic disease in a subject using a fully implantable electrical stimulation system to provide or administer a therapy. In certain aspects a stimulation lead is implanted proximally to a stomach acupoint, the stimulation lead being coupled to an implantable signal generator; and stimulating the acupoints using the signal generator to treat the metabolic disease.
1. A method of reducing food intake in a subject using an implantable electrical stimulation system comprising:
permanently implanting a stimulation electrode at a first location, wherein the stimulation electrode is in communication with a stomach acupoint;
permanently implanting a signal generator at a second location and connecting the stimulation electrode and the signal generator using a connector; and
reducing food intake by stimulating the stomach acupoint in the subject in need of a reduced food intake via the implanted stimulation electrode that is in communication with the stomach acupoint and coupled to the permanently implanted signal generator, wherein stimulating the acupoint reduces the subject's food intake.
2. The method of claim 1 wherein the electrical stimulation system delivers pulses on a substantially continuous basis.
3. The method of claim 1 , wherein the electrical signal is a pulse train of 0.1-2 seconds on and 0.1-3 seconds off.
4. The method of claim 3 , wherein the pulse train comprises a pulse of 0.1 to 1 ms.
5. The method of claim 3 , wherein the pulse train comprises a pulse of 1-300 Hz.
6. The method of claim 3 , wherein the pulse train comprises a pulse of 0.1 to 10 mA.
7. The method of claim 1 , wherein the stomach acupoint is Zusanli (ST 36 ), Liangmen (ST 21 ), or Tianshu (ST 25 ).
8. The method of claim 7 further comprising stimulating one or more of Neiguan (PC 6 ), Guangyaun (R 4 ), and Quchi (LI 11 ).
9. The method of claim 7 wherein the stomach acupoint is Zusanli (ST 36 ).
10. The method of claim 1 wherein the stimulation electrode comprises an implantable needle.
11. The method of claim 1 wherein the stimulation electrode comprises a percutaneous lead, a paddle lead or a patch electrode.
12. The method of claim 1 , wherein stimulation is electrical.
13. The method of claim 1 , wherein stimulation is magnetic.
14. The method of claim 1 , wherein stimulation is microwave.
15. The method of claim 1 , wherein the stimulatory signal is synchronized in response to the subject's breathing.
16. The method of claim 1 , wherein breathing is synchronized in response to the stimulatory signal.
17. A method of treating diabetes or obesity in a subject using an implantable electrical stimulation system comprising:
stimulating a permanently implanted stimulation electrode that is in communication with one or more stomach acupoints in a subject that is diabetic or obese selected from the group consisting of Zusanli (ST 36 ), Liangmen (ST 21 ), Tianshu (ST 25 ), Zhong Wan (CV 4 ) and Guanyuan (CV 12 ) and is coupled to a permanently implanted signal generator positioned at a location other than the acupoint;
wherein stimulating the stimulation electrode treats diabetes or obesity.
18. The method of claim 1 , wherein the signal generator is implanted in the subject's abdomen.