Composition containing phospholipid-DHA and folate
Described herein are manufactured dietary supplements that contain a phospholipid extract and the extract contains two forms of phospholipid-docosahexanoic acid. One form of phospholipid-docosahexanoic acid is phosphatidylcholine-docosahexanoic acid, and another form of phospholipid-docosahexanoic acid is phosphatidylethanolamine-docosahexanoic acid. The manufactured dietary supplement also contains L-methylfolate.
1. A manufactured composition comprising: a phospholipid extract at a concentration ranging from 50 mg to 500 mg, the phospholipid extract having phosphatidylcholine-docosahexaenoic acid and phosphatidylethanolamine-docosahexaenoic acid at a ratio ranging from 1:1 to 2:1, and
a pharmaceutically acceptable reduced folate salt.
2. The manufactured composition of claim 1 , wherein the reduced folate salt is an L-methylfolate salt.
3. The manufactured composition of claim 2 , wherein the amount of L-methylfolate salt is between about 5 mg and about 20 mg.
4. The manufactured composition of claim 2 , wherein the amount of L-methylfolate salt is about 15 mg.
5. The manufactured composition of claim 2 , wherein the L-methylfolate salt is L-methylfolate calcium.
6. The manufactured composition of claim 2 , wherein the L-methylfolate salt is L-methylfolate magnesium.
7. The manufactured composition of claim 1 , wherein the phospholipid extract is derived from eggs.
8. The manufactured composition of claim 1 , wherein the phospholipid extract contains less than 5%, by weight, triglycerides.
9. The manufactured composition of claim 1 , wherein the phospholipid extract contains less than 0.5%, by weight, free fatty acids.
10. The manufactured composition of claim 1 , wherein the phospholipid extract is substantially free of phosphatidylserine.
11. The manufactured composition of claim 1 , wherein the phospholipid extract is substantially free of eicosapentaenoic acid.
12. The manufactured composition of claim 1 , wherein the phospholipid extract is derived from non-genetically modified organism.
13. The manufactured composition of claim 1 , wherein between about 5% and about 15% of the phospholipid extract is phosphatidylcholine-docosahexaenoic acid.
14. The manufactured composition of claim 1 , wherein between about 5% and about 15% of the phospholipid extract is phosphatidylethanolamine-docosahexaenoic acid.
15. The manufactured composition of claim 1 , wherein at least about 20% of the phospholipid extract, by weight, is phospholipid-docosahexaenoic acid.
16. The manufactured composition of claim 1 , wherein the manufactured composition is a tablet, softgel, capsule, or chewable.
17. The manufactured composition of claim 1 , wherein the phospholipid extract comprises less than 1.5% eicosapentaenoic acid by weight.
18. A manufactured composition consisting essentially of: a phospholipid extract at a concentration ranging from about 50 mg to about 500 mg, the phospholipid extract having phosphatidylcholine-docosahexaenoic acid and phosphatidylethanolamine-docosahexaenoic acid at a ratio ranging from 1:1 to 2:1, and
a pharmaceutically acceptable reduced folate salt at a concentration ranging from about 5 mg to about 20 mg.
19. The manufactured composition of claim 1 , wherein the composition additionally comprises a stabilizer that increases stability of the composition for longer shelf-life.