Isoindoline compounds and methods of their use

1. A compound of Formula III:

or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, wherein:

X is C(═O) or CH 2 ;

m is an integer of 0, 1, 2, or 3;

R 5 and R 6 are each independently: hydrogen, halo, C 1-6 alkyl, oxo, —NO 2 , C 1-6 alkoxy, —Z—C 1-6 alkyl, C 0-6 alkyl-(5 to 10 membered heteroaryl), C 0-6 alkyl-(5 to 6 membered heterocyclyl), C 0-6 alkyl-OH, C 0-4 alkyl-NH 2 , —NHCO—C 1-6 alkyl, —OR 21 , or —(CH 2 —Y) 0-2 -(5 to 10 membered heteroaryl),

wherein Z is S or SO 2 ;

wherein R 21 is as defined above;

wherein each heteroaryl and heterocyclyl above is optionally substituted with one or more C 1-6 alkyl; and

wherein the alkyl or alkoxy above may be optionally substituted with one or more: halogen; cyano; nitro; amino; C 1-6 alkylidenedioxy; C 1-6 alkoxy, itself optionally substituted with one or more halogens; or C 1-6 alkylthio, itself optionally substituted with one or more halogens;

R 7 is —COR 71 or —PO(OR 72 )(OR 73 );

R 71 is C 1-10 alkyl, C 6-10 aryl, or 5 to 6 membered heterocyclyl; wherein the alkyl, aryl, heterocyclyl may be optionally substituted with one or more amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, or —COOR 74 ; and

R 72 , R 73 , and R 74 are each independently hydrogen or C 1-10 alkyl.

2. The compound of claim 1 , wherein R 5 is fluoro or chloro.

3. The compound of claim 1 , wherein R 6 is fluoro or chloro.

4. The compound of claim 1 , which is:

or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof.

5. A pharmaceutical composition comprising the compound of claim 1 , and one or more pharmaceutically acceptable excipients or carriers.

6. The pharmaceutical composition of claim 5 , further comprising a second therapeutic agent.

7. The pharmaceutical composition of claim 5 , wherein the composition is formulated for single dose administration.

8. The pharmaceutical composition of claim 5 , wherein the composition is formulated as oral, parenteral, or intravenous dosage form.

9. The pharmaceutical composition of claim 8 , wherein the oral dosage form is a tablet or capsule.

10. A method of treating or managing a disease or disorder which comprises administering to a subject a therapeutically effective amount of a compound of any of claims 1 to 4 , wherein the disease is cancer.

11. The method of claim 10 , wherein the cancer is hematologic or solid cancer.

12. The method of claim 9 , which further comprises administration of one or more additional active agents.

13. The method of claim 9 , wherein the compound is administered orally or parenterally.