Allosteric modulators of CB1 cannabinoid receptors
The present invention relates to novel heterocyclic derivatives which are allosteric modulators of cannabinoid receptor 1 (CB1) and which are useful for the treatment or prevention of neurological and psychiatric disorders associated with endocannabinoid dysfunction and diseases in which the CB1 subtype of cannabinoid receptor is involved; to processes for their preparation; to pharmaceutical compositions comprising them; and to methods of using them.
1. A compound having the following structure, or a pharmaceutically acceptable salt thereof:
wherein Y 1 is C or N;
Z is NO 2 ;
each R 1 is independently H, halogen, OH, CN, (C 1 -C 6 )alkyl, or haloalkyl;
each R 2 is independently H, halogen, OH, or CN;
each R 3 is independently H, OH, CN, or piperdinyl;
m is 1-4; and
n is 1-5; provided the compound is not:
2. The compound of claim 1 , wherein the compound is a compound of structure (IC) and at least one R 2 is selected from the group consisting of Cl and F.
3. The compound of claim 1 , wherein the compound is a compound of structure (IC) and Y 1 is C.
4. A compound having a structure selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
5. A pharmaceutical composition comprising a pharmaceutically-acceptable carrier or diluent and at least one compound having the following structure, or a pharmaceutically acceptable salt thereof:
wherein Y 1 is C or N;
Z is NO 2 ;
each R 1 is independently H, halogen, OH, CN, (C 1 -C 6 )alkyl, or haloalkyl;
each R 2 is independently H, halogen, OH, or CN;
each R 3 is independently H, OH, CN, or piperdinyl;
m is 1-4; and
n is 1-5; provided the compound is not:
6. The pharmaceutical composition of claim 5 , wherein the compound is a compound of structure (IC) and at least one R 2 is selected from the group consisting of Cl and F.
7. A pharmaceutical composition comprising a pharmaceutically-acceptable carrier or diluent and at least one compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.