Modified acidic fibroblast growth factors and composition thereof
The present invention provides acidic fibroblast growth factor (aFGF) composition, comprising: (i) aFGF of SEQ ID NO: 1, (ii) aFGF of SEQ ID NO: 1 having an N-terminal phosphogluconoylation, (iii) aFGF of SEQ ID NO: 1 having an N-terminal gluconoylation, (iv) aFGF of SEQ ID NO: 2 and (v) aFGF of SEQ ID NO: 3, or a combination thereof. Also provided is a modified acidic fibroblast growth factor (aFGF) which has an N-terminal phosphogluconoylation or gluconoylation.
1. A peptide consisting of the modified acidic fibroblast growth factor (aFGF) of SEQ ID NO: 1 where the N-terminal is phosphogluconoylated.
2. A peptide consisting of the modified acidic fibroblast growth factor (aFGF) of SEQ ID NO: 1 where the N-terminal is gluconoylated.
3. A peptide consisting of the modified acidic fibroblast growth factor (aFGF) of SEQ ID NO: 2.
4. A peptide consisting of the modified acidic fibroblast growth factor (aFGF) of SEQ ID NO: 3.