Oxidized LDL as a biomarker for neurological complications of pregnancy
View Patent ↗Methods for diagnosing and treating conditions associated with life-threatening neurological complications are provided. The methods involve in some aspects the identification of oxLDL and LOX-1 as critical players in pregnant subjects and in some cases subjects having severe preeclampsia (early onset preeclampsia). Related products and kits are also provided.
1. A method for identifying a subject at risk of seizure, comprising isolating a tissue sample from a pregnant subject wherein the pregnant subject does not have preeclampsia and wherein blood pressure of the subject is within normal levels, measuring a level of oxLDL in the pregnant subject, wherein the subject is at risk of seizure if the oxLDL levels are greater than a control level, and further comprising administering an anti-seizure prophylaxis to the subject if the levels of oxLDL are greater than a control level.
2. The method of claim 1 , wherein the oxLDL levels are greater than 1,600 ng/ml.
3. The method of claim 1 , wherein the tissue sample is a blood sample.
4. The method of claim 1 , wherein the anti-seizure prophylaxis is magnesium sulfate.
5. The method of claim 1 , wherein the levels of oxLDL are measured using an antibody assay.
6. The method of claim 1 , wherein the levels of oxLDL are measured using a kit for detecting oxLDL.
7. The method of claim 1 , wherein the subject is in the first trimester of pregnancy.
8. The method of claim 1 , wherein the subject is in the second trimester of pregnancy.
9. The method of claim 1 , wherein the subject is in the third trimester of pregnancy.
10. The method of claim 1 , further comprising measuring the cholesterol of the subject.
11. The method of claim 10 , wherein the cholesterol of the subject is above normal levels.