Natriuretic polypeptides
View Patent ↗This document provides methods and materials related to natriuretic polypeptides and the use of natriuretic polypeptides to treat cardiovascular and/or renal conditions. For example, chimeric polypeptides having at least one amino acid segment (e.g., N-terminus tail, ring structure, C-terminus tail, or a combination thereof) of a natriuretic peptide (e.g., ANP, BNP, CNP, URO, or DNP) and an amino acid segment of an angiotensin polypeptide (e.g., Ang-(1-7)) are provided.
1. A polypeptide from 20 to 28 amino acid residues in length, wherein said polypeptide comprises, in an order from amino terminus to carboxy terminus:
(a) the sequence set forth in SEQ ID NO: 1 or the sequence set forth in SEQ ID NO: 1 with no more than two additions, deletions, or substitutions, and
(b) the sequence set forth in SEQ ID NO:7 or the sequence set forth in SEQ ID NO:7 with no more than five additions, deletions, or substitutions.
2. The polypeptide of claim 1 , wherein said polypeptide comprises the sequence set forth in SEQ ID NO:1.
3. The polypeptide of claim 1 , wherein said polypeptide comprises the sequence set forth in SEQ ID NO:7.
4. The polypeptide of claim 1 , wherein said polypeptide lacks a C-terminal tail attached to a ring structure.
5. The polypeptide of claim 1 , wherein said polypeptide comprises the sequence set forth in SEC) ID NO:34 with no more than five additions, deletions, or substitutions.