Methods for anticoagulating blood
Methods are provided for anticoagulating blood. Whole blood is drawn from a donor into a system at a draw flow rate. Anticoagulant from an anticoagulant source is pumped into the system at an anticoagulant flow rate to mix with the blood. The anticoagulated blood may be subsequently processed in any of a number of known ways, including separating it and removing at least a portion of one of the components of the blood. Thereafter, at least a portion of the remaining blood may be returned to the donor. The anticoagulant flow rate is independent of the draw flow rate and can be based on a number of factors, including the weight of the donor and the rate at which the donor can metabolize the anticoagulant.
1. A method for anticoagulating blood, comprising:
drawing whole blood from a donor at a draw flow rate; adding anticoagulant containing a citrate to the whole blood at an anticoagulant flow rate;
processing at least a portion of the anticoagulated blood; and
returning at least a portion of the anticoagulated blood to the donor, wherein the anticoagulant flow rate is independent of the draw flow rate and is calculated using the formula “AC=S*CIR*weight/concentration”, where “AC” is the anticoagulant flow rate, “S” is a factor equal to the inverse of the percentage of anticoagulant to be returned to the donor, “CIR” is a citrate infusion rate at which the donor can metabolize said citrate, “weight” is the weight of the donor, and “concentration” is the citrate concentration of the anticoagulant.
2. The method of claim 1 , wherein the anticoagulant flow rate is substantially constant.
3. The method of claim 1 , further comprising subjecting the whole blood drawn from the donor to a pathogen inactivation procedure.
4. The method of claim 1 , wherein said adding anticoagulant to the whole blood includes continuously adding anticoagulant to the whole blood.
5. The method of claim 1 , further comprising monitoring the ratio of the draw flow rate to the anticoagulant flow rate to prevent the ratio from exceeding a preselected value.