IP Library › Granted Patent US 9,610,274
Granted Patent B2
US 9,610,274 · App. 12/827,505 · Granted Apr 4, 2017

Methods for treating bipolar disorder

Inventors: Sung James Lee (Montville, NJ); Susan Marie Melnick (Parsippany, NJ)
Assignee: SK BIOPHARMACEUTICALS CO., LTD.
A61K31/27
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Quick Facts
Patent No.
US 9,610,274
App. No.
12/827,505
Granted
Apr 4, 2017
Kind
B2
Abstract

The invention is directed to a method of treating bipolar disorder in a subject, comprising administering a therapeutically effective amount of a carbamate compound, or pharmaceutically acceptable salt or amide thereof.

Claims (18)

1. A method of diminishing manic symptoms in a mammal suffering from bipolar disorder, wherein the mammal is exhibiting manic symptoms of bipolar disorder, comprising the administration of a therapeutically effective amount of a compound having structural Formula (1) or a pharmaceutically acceptable salt thereof, to a mammal in need thereof:

wherein,

R is hydrogen;

x is 1; and

R 1 and R 2 are hydrogen,

to thereby diminish the manic symptoms in the mammal suffering from bipolar disorder.

2. The method of claim 1 , wherein the compound having structural Formula (1) is an enantiomer substantially free of other enantiomers or an enantiomeric mixture wherein one enantiomer of the compound having structural Formula (1) predominates.

3. The method of claim 2 , wherein one enantiomer predominates to the extent of about 90% or greater.

4. The method of claim 3 , wherein one enantiomer predominates to the extent of about 98% or greater.

5. The method of claim 2 , wherein the enantiomer is (S) or (L) enantiomer as represented by Structural Formula (1a):

6. The method of claim 5 , wherein one enantiomer predominates to the extent of about 90% or greater.

7. The method of claim 6 , wherein one enantiomer predominates to the extent of about 98% or greater.

8. The method of claim 2 , wherein the enantiomer is (R) or (D) enantiomer, as represented by Structural Formula (1b):

9. The method of claim 8 , wherein one enantiomer predominates to the extent of about 90% or greater.

10. The method of claim 9 , wherein one enantiomer predominates to the extent of about 98% or greater.

11. The method of claim 8 , wherein the enantiomer is (R)-(beta-amino -benzenepropyl)carbamate.

12. The method of claim 11 , wherein the enantiomer of (R)-(beta-amino -benzenepropyl)carbamate predominates to the extent of about 90% or greater.

13. The method of claim 12 , wherein the enantiomer of (R)-(beta-amino -benzenepropyl)carbamate predominates to the extent of about 98% or greater.

Assignments (3)
CORRECTIVE ASSIGNMENT TO CORRECT THE MAILING ADDRESS COUNTRY OF THE ASSIGNEE PREVIOUSLY RECORDED ON REEL 026892 FRAME 0846. ASSIGNOR(S) HEREBY CONFIRMS THE MAILING ADDRESS COUNTRY OF THE ASSIGNEE SHOULD BE CHANGED FROM "KOREA, DEMOCRATIC PEOPLE'S REPUBLIC OF" TO "KOREA, REPUBLIC OF". Recorded Nov 6, 2013
From: SK HOLDINGS CO., LTD.
To: SK BIOPHARMACEUTICALS CO., LTD.
Reel/Frame 031589/0390 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 13, 2011
From: SK HOLDINGS CO., LTD.
To: SK BIOPHARMACEUTICALS CO., LTD.
Reel/Frame 026892/0846 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 30, 2010
From: LEE, SUNG JAMES; MELNICK, SUSAN MARIE
To: SK HOLDINGS CO., LTD.
Reel/Frame 024619/0096 →
Continuity (1)
Related Publication 20120004300A1 · Jan 5, 2012