RSV antiviral compounds

1. The compound according to formula (RI)

wherein Het is selected from the group consisting of: formula (a′), (b′), (c′), and (d′):

wherein each X independently is C or N; wherein at least one X is N;

each of R 1a , R 1b , R 1c , R 1d is halogen; and R 1b or R 1d is absent when the X to which it is bound is N;

each R 2 is —(CR 8 R 9 ) m —R 10 ;

m is an integer from 0 to 6;

each R 8 and R 9 are independently selected from the group consisting of: H, C 1 -C 10 alkyl and C 3 -C 7 cycloalkyl; or R 8 and R 9 are taken together form a 4 to 6 membered saturated ring that optionally contains one or more heteroatoms selected from the group consisting of: N, S and O;

each R 10 is independently selected from the group consisting of: H, halogen, OH, CN, CF 2 H, CF 3 , C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C(═O)C 1 -C 6 alkyl, C(═O)C 3 -C 7 cycloalkyl, C(═O)NR 8 R 9 , C(═O)OR 8 , SO 2 R 8 , C(═O)N(R 8 )SO 2 R 9 , C(═O)N(R 8 )SO 2 N(R 8 R 9 ), NR 8 R 9 , NR 8 C(═O)OR 9 , OC(═O)R 8 , O-benzyl, NR 8 SO 2 R 9 , SO 2 NR 8 R 9 , SO 2 R 8 , OC(═O)NR 8 R 9 , OC(═O)NR 8 R 12 , N(R 8 )C(═O)N(R 8 R 9 ), R 11 , N(R 8 )C(═O)OR 12 , OR 11 , C(═O)R 11 , and a 4 to 6 membered saturated ring containing one oxygen atom;

R 11 phenyl, pyridinyl or pyrazolyl; wherein each phenyl, pyridinyl or pyrazolyl can be optionally substituted with one or more substituents each independently selected from the group consisting of: CF 3 , CH 3 , OCH 3 , OCF 3 , and halogen;

R 12 is C 1 -C 6 alkyl or C 3 -C 7 cycloalkyl; wherein each C 1 -C 6 alkyl or C 3 -C 7 cycloalkyl is substituted with one or more substituents each independently selected from the group consisting of: CF 3 , CH 3 , OCH 3 , OCF 3 , and halogen;

each Z independently is C or N, provided that at least two Z are C;

Q and V each independently represent C═O, SO 2 or CR 20 R 21 ;

p and s independently represent an integer from 0 to 3, wherein the sum of p and s minimally should be 2, and when p=0 or s=0 then the carbon atom marked with * is directly bound to W;

R 20 and R 21 are each independently selected from the group consisting of: hydrogen, hydroxyl, C 1 -C 3 alkyl, C 3 -C 7 cycloalkyl, CF 3 , OCH 3 , OCF 3 , and halogen;

R 22 is selected from the group consisting of: hydrogen, hydroxyl, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, CF 3 , OCH 3 , OCF 3 , and halogen;

W is selected from the group consisting of: SO, SO 2 , S, C, O, and N, wherein such C or N is optionally substituted with one or more R 23 ;

R 23 is selected from the group consisting of: hydrogen, hydroxyl, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 6 alkyl-R 24 , SO 2 R 24 SO 2 N(R 24 ) 2 , aryl, heteroaryl, C(═O)OR 24 , OR 24 , C(═O)R 24 , C(═O)N(R 24 ) 2 , OC(═O)N(R 24 ) 2 , P(═O)—(O—C 1 -C 6 -alkyl) 2 , N(R 24 ) 2 , NR 25 C(═O)OR 24 , NR 25 C(═O)N(R 24 ) 2 , NR 25 SO 2 R 24 , and a 4 to 6 membered saturated ring containing one oxygen atom, wherein any of such C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, aryl or heteroaryl is optionally substituted with one or more substituents each independently selected from the group consisting of: halogen, OH, CN, and OCH 3 ;

R 24 is selected from the group of: hydrogen, OH, halogen, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C(═O) C 1 -C 6 alkyl, C(═O) C 3 -C 7 cycloalkyl, aryl, heteroaryl, benzyl, and a 4 to 6 membered saturated ring containing one oxygen atom; wherein any of such C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C(═O) C 1 -C 6 alkyl, C(═O) C 3 -C 7 cycloalkyl, aryl, heteroaryl, and benzyl is optionally substituted with one or more substituents each independently selected from the group consisting of: halogen, CF 3 , OH, CN, OCH 3 , OC(═O)CH 3 ), and C 1 -C 3 alkyl substituted with at least one CN;

R 25 is selected from the group consisting of hydrogen and C 1 -C 3 alkyl;

aryl represents phenyl or naphthalenyl;

heteroaryl represents a monocyclic 5 to 6 membered aromatic heterocycle containing one or more heteroatoms each independently selected from the group consisting of: O, S and N; or a bicyclic 8 to 12 membered aromatic heterocycle containing one or more heteroatoms each independently selected from the group consisting of: O, S and N;

or a pharmaceutically acceptable addition salt or a solvate thereof.

2. The compound according to claim 1 , wherein for Formula (b′) and (d′), one X is N.

3. A compound according to claim 1 , wherein each of R 1a , R 1b , R 1c or R 1d is independently selected from the group consisting of: chloro, bromo and fluoro.

4. A compound according to claim 1 , wherein each of R 1a , R 1b , R 1c or R 1d is chloro.

5. A compound according to claim 1 , wherein R 2 is —(CR 8 R 9 ) m —R 10 ; m is an integer from 1 to 4; and each of R 8 and R 9 is independently selected from: H or C 1 -C 6 alkyl.

6. A compound according to claim 1 , wherein R 2 is C 1 -C 6 alkyl-R 10 .

7. A compound according to claim 6 , wherein R 10 is selected from the group consisting of: C 1 -C 3 alkyl, H, OH, CN, F, CF 2 H, CF 3 , SO 2 —C 1 -C 3 alkyl, and SO 2 C 3 -C 6 cycloalkyl.

8. A compound according to claim 1 , wherein the compound has the Formula selected from the group consisting of: RII, RIII, RIV, RV, RVI and RVII:

or any stereoisomeric form thereof.

9. The compound as claimed in claim 8 wherein R 23 is selected from the group consisting of hydrogen, hydroxyl, C 1 -C 6 alkyl, C 1 -C 3 alkyl-R 24 , SO 2 R 24 , O—R 24 , phenyl, pyridinyl pyrimidyl, pyrazolyl, C(═O)OR 24 , and C(═O)R 24 , wherein any of such C 1 -C 6 alkyl, phenyl, pyridinyl, pyrimidyl, and pyrazolyl is optionally substituted with one or more members each independently selected from the group consisting of: OCH 3 , halogen, OH and CN.

10. A pharmaceutical composition comprising a pharmaceutically acceptable carrier, and as active ingredient a compound as claimed in claim 1 .

11. A method for treating viral RSV infections comprising administering to a subject in need thereof, a therapeutically effective amount of a compound as claimed in claim 1 .

12. A method for treating viral RSV infections comprising administering to a subject in need thereof, a therapeutically effective amount of a composition as claimed in claim 10 .

13. The compound selected from the group consisting of:

tert-butyl 1′-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-2′-oxo-1′,2′-dihydro-1H-spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

1′-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

1′-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

tert-butyl 1′-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-2′-oxo-1′,2′-dihydro-1H-spiro[azetidine-3,3′-indole]-1-carboxylate;

1′-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)spiro[azetidine-3,3′-indol]-2′(1′H)-one;

1′-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-1-(2-hydroxy-2-methylpropanoyl)spiro[azetidine-3,3′-indol]-2′(1′H)-one;

1′-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-1-(pyridin-3-yl)spiro[azetidine-3,3′-indol]-2′(1′H)-one;

1′-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-1-(2-hydroxy-2-methylpropyl)spiro[azetidine-3,3′-indol]-2′(1′H)-one;

1′-[[5-chloro-1-(3-methylsulfonylpropyl)benzimidazol-2-yl]methyl]-1-(2,2,2-trifluoroethyl)spiro[azetidine-3,3′-indoline]-2′-one;

1-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-6-fluoro-2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-2-one;

(3S)-1′-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-3-hydroxyspiro[cyclobutane-1,3′-indol]-2′(1′H)-one;

(3R)-1′-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-3-hydroxyspiro[cyclobutane-1,3′-indol]-2′(1′H)-one;

1′-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-1-(quinoxalin-6-ylsulfonyl)spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

tert-butyl 1′-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxo-1′,2′-dihydrospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

1-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-1′-(6-chloropyridazin-3-yl)spiro[indoline-3,4′-piperidin]-2-one;

1-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-1′-(quinoxalin-6-ylsulfonyl)spiro[indoline-3,4′-piperidin]-2-one;

tert-butyl 1-((5-bromo-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-2-oxospiro[indoline-3,4′-piperidine]-1′-carboxylate;

4-(1-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-2-oxospiro[indoline-3,4′-piperidine]-1′-yl sulfonyl)benzonitrile;

1-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-5-fluoro-2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-2-one;

5-bromo-1-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-1′-(6-chloropyridazin-3-yl)spiro[indoline-3,4′-piperidin]-2-one;

1-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)spiro[indoline-3,4′-piperidin]-2-one;

5-bromo-1-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-1′-isonicotinoylspiro[indoline-3,4′-piperidin]-2-one;

tert-butyl 5-bromo-1-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-2-oxospiro[indoline-3,4′-piperidine]-1′-carboxylate;

1′-acetyl-5-chloro-1-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)spiro[indoline-3,4′-piperidin]-2-one;

5-chloro-1-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-1′-(2-hydroxy-2-methylpropyl)spiro[indoline-3,4′-piperidin]-2-one;

4-chloro-1-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-acetyl-4-chloro-1-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-1-(2-methylpropanoyl)spiro[azetidine-3,3′-indol]-2′(1′H)-one;

1′-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-1-(cyclopropylsulfonyl)spiro[azetidine-3,3′-indol]-2′(1′H)-one;

1-acetyl-1′-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)spiro[azetidine-3,3′-indol]-2′(1′H)-one;

1′-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-1-(trifluoroacetyl)spiro[azetidine-3,3′-indol]-2′(1′H)-one;

1′-acetyl-1-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-1-[(4-fluorophenyl)sulfonyl]spiro[azetidine-3,3′-indol]-2′(1′H)-one;

1-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-1′-[(4-fluorophenyl)sulfonyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-1′-(cyclopropylsulfonyl)spiro[indole-3,4′-piperidin]-2(1H)-one;

1-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-1′-[(4-methoxyphenyl)sulfonyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)spiro[cyclopentane-1,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

1′-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-2,3,5,6-tetrahydrospiro[pyran-4,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

tert-butyl 1-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-2-oxospiro[indoline-3,4′-piperidine]-1′-carboxylate;

1-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-2-one;

1′-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-2,3,5,6-tetrahydrospiro[pyran-4,3′-pyrrolo[3,2-c]pyridin]-2′(1′H)-one;

1-acetyl-1′-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

4-fluorophenyl 1′-((5-chloro-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxospiro[azetidine-3,3′-indoline]-1-carboxylate;

tert-butyl 1′-((5-chloro-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxospiro[azetidine-3,3′-indoline]-1-carboxylate;

isobutyl 1′-((5-chloro-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxospiro[azetidine-3,3′-indoline]-1-carboxylate;

1′-((5-chloro-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)spiro[azetidine-3,3′-indolin]-2′-one;

Cyclopentyl 1-((5-chloro-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-2-oxospiro[indoline-3,4′-piperidine]-1′-carboxylate;

tert-butyl 1-((5-chloro-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-2-oxospiro[indoline-3,4′-piperidine]-1′-carboxylate;

1-((5-chloro-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)spiro[indoline-3,4′-piperidin]-2-one;

benzyl 1-((5-chloro-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-2-oxospiro[indoline-3,4′-piperidine]-1′-carboxylate;

1′-benzyl-1-((5-chloro-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)spiro[indoline-3,4′-piperidin]-2-one;

1-((5-chloro-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-2-one;

tert-butyl 1′-((5-chloro-1-(3-cyanopropyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxo-1′,2′-dihydrospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

1′-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)spiro[cyclopentane-1,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

1′-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-2′-oxo-1′,2′-dihydro-1H-spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

1-acetyl-1′-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

1′-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-indol-2-yl)methyl)-2,3,5,6-tetrahydrospiro[pyran-4,3′-pyrrolo[3,2-c]pyridin]-2′(1′H)-one;

tert-butyl 1′-{[5-chloro-1-(3-cyanopropyl)-1H-indol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[azetidine-3,3′-indole]-1-carboxylate;

4-{5-chloro-2-[(2′-oxospiro[azetidine-3,3′-indol]-1′(2′H)-yl)methyl]-1H-indol-1-yl}butanenitrile;

1′-{[5-chloro-1-(3-cyanopropyl)-1H-indol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[azetidine-3,3′-indole]-1-carboxylate;

4-(5-chloro-2-{[1-(cyclopropylsulfonyl)-2′-oxospiro[azetidine-3,3′-indol]-1′(2′H)-yl]methyl}-1H-indol-1-yl)butanenitrile;

4-{2-[(1-acetyl-2′-oxospiro[azetidine-3,3′-indol]-1′(2′H)-yl)methyl]-5-chloro-1H-indol-1-yl}butanenitrile;

tert-butyl 1′-((5-chloro-1-(3-cyanopropyl)-1H-indol-2-yl)methyl)-2′-oxo-1′,2′-dihydrospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

4-(2-((1-acetyl-2′-oxospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-1′(2′H)-yl)methyl)-5-chloro-1H-indol-1-yl)butanenitrile;

1′-((5-chloro-1-(4,4,4-trifluorobutyl)-1H-imidazo[4,5-b]pyridin-2-yl)methyl)spiro[cyclopentane-1,3′-pyrrolo[2,3-c]pyridin]-2′ (1′H)-one;

tert-butyl-2′-oxo-1′-((1-(4,4,4-trifluorobutyl)-1H-imidazo[4, 5-b]pyridine-2-yl)methyl)-1′,2′-dihydrospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

1′-((5-chloro-1-(4,4,4-trifluorobutyl)-1H-imidazo[4, 5-b]pyridin-2-yl)methyl)-2,3,5,6-tetrahydrospiro[pyran-4,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

tert-butyl-1′ 4(5-chloro-1-(4,4,4-trifluorobutyl)-1H-imidazo[4,5-b]pyridin-2-yl)methyl)-2′-oxo-1′,2′-dihydrospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

tert-butyl 1′-((5-chloro-1-(4-fluorobutyl)-1H-pyrrolo[3,2-b]pyridin-2-yl)methyl)-2′-oxo-1′,2′-dihydrospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

tert-butyl 1′-((5-chloro-1-(3-cyanopropyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxospiro[azetidine-3,3′-indoline]-1-carboxylate;

1-((5-chloro-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-6-fluoro-2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-2-one;

1-acetyl-1′-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)spiro[azetidine-3,3′-indolin]-2′-one;

4-(5-chloro-2-((1-(2-hydroxy-2-methylpropanoyl)-2′-oxospiro[azetidine-3,3′-indolin]-1′-yl)methyl)-1H-indol-1-yl)butanenitrile;

1′-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-indol-2-yl)methyl)-1-(2-hydroxy-2-methylpropanoyl)spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

1′-((5-chloro-1-(4,4,4-trifluorobutyl)-1H-imidazo[4,5-b]pyridin-2-yl)methyl)-2,3,5,6-tetrahydrospiro[pyran-4,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

methyl 1′-((5-chloro-1-(3-cyanopropyl)-1H-indol-2-yl)methyl)-2′-oxo-1′,2′-dihydrospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

isopropyl 1′-((5-chloro-1-(3-cyanopropyl)-1H-indol-2-yl)methyl)-2′-oxo-1′,2′-dihydrospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

4-(5-chloro-2-((2′-oxospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-1′(2′H)-yl)methyl)-1H-indol-1-yl)butanenitrilehydrochloride;

1-(1′-((5-chloro-1-(3-cyanopropyl)-1H-indol-2-yl)methyl)-2′-oxo-1′,2′-dihydrospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-1-yl)-2-methyl-1-oxopropan-2-ylacetate;

oxetan-3-yl 1′-((5-chloro-1-(3-cyanopropyl)-1H-indol-2-yl)methyl)-2′-oxo-1′,2′-dihydrospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

4-(5-chloro-2-((1-(cyclopropylsulfonyl)-2′-oxospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-1′(2′H)-yl)methyl)-1H-indol-1-yl)butanenitrile;

oxetan-3-yl 1′-((5-chloro-1-(3-cyanopropyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxo-1′,2′-dihydrospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

4-(2-((1-acetyl-2′-oxospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-1′(2′H)-yl)methyl)-5-chloro-1H-benzo[d]imidazol-1-yl)butanenitrile;

4-(5-chloro-2-((2′-oxospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-1′(2′H)-yl)methyl)-1H-benzo[d]imidazol-1-yl)butanenitrilehydrochloride;

1′-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-1-(cyclopropyl sulfonyl)spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

4-(5-chloro-2-((1-(2-hydroxy-2-methylpropanoyl)-2′-oxospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-1′(2′H)-yl)methyl)-1H-indol-1-yl)butanenitrile;

isopropyl 1′-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxo-1′,2′-dihydrospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

4-(2-((1-acetyl-2′-oxospiro[azetidine-3,3′-indolin]-1′-yl)methyl)-5-chloro-1H-benzo[d]imidazol-1-yl)butanenitrile;

1′-((5-chloro-1-(3-cyanopropyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxo-1′,2′-dihydrospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-sulfonamide;

1′-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-1-(cyclopropylcarbonyl)spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

4-(5-Chloro-2-{[2′-oxo-1-(thiophen-2-ylsulfonyl)spiro[azetidine-3,3′-indol]-1′(2′H)-yl]methyl}-1H-benzimidazol-1-yl)butanenitrile;

Oxetan-3-yl 1′-{[5-chloro-1-(3-cyanopropyl)-1H-benzimidazol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[azetidine-3,3′-indole]-1-carboxylate;

4-[5-Chloro-2-({1-[(4-fluorophenyl)sulfonyl]-2′-oxospiro[azetidine-3,3′-indol]-1′(2′H)-yl}methyl)-1H-benzimidazol-1-yl]butanenitrile;

4-(5-Chloro-2-{[1-(methylsulfonyl)-2′-oxospiro[azetidine-3,3′-indol]-1′(2′H)-yl]methyl}-1H-benzimidazol-1-yl)butanenitrile;

N-[(1′-{[5-Chloro-1-(3-cyanopropyl)-1H-benzimidazol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-1-yl)sulfonyl]acetamide;

4-(5-Chloro-2-{[2′-oxo-1-(thiophen-2-ylsulfonyl)spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-1′(2′H)-yl]methyl}-1H-indol-1-yl)butanenitrile;

tert-Butyl 1′-{[1-(3-methylbutyl)-1H-pyrrolo[3,2-c]pyridin-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

Methyl 1′-{[5-chloro-1-(3-cyanopropyl)-1H-benzimidazol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

1-Methylethyl 1′-{[5-chloro-1-(3-cyanopropyl)-1H-benzimidazol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

4-{5-Chloro-2-[(2′-oxospiro[azetidine-3,3′-indol]-1′(2′H)-yl)methyl]-1H-benzimidazol-1-yl}butanamide;

4-{5-Chloro-2-[(2′-oxospiro[azetidine-3,3′-indol]-1′(2′H)-yl)methyl]-1H-benzimidazol-1-yl}butanenitrile;

1-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-1′-(thiophen-2-ylsulfonyl)spiro[indole-3,4′-piperidin]-2(1H)-one;

Cyclobutyl 1′-{[5-chloro-1-(3-cyanopropyl)-1H-indol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

(1R,3R)-1′-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxospiro[cyclobutane-1,3′-indoline]-3-ylmethylcarbamate;

4-(5-Chloro-2-{[1-(methylsulfonyl)-2′-oxospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-1′(2′H)-yl]methyl}-1H-indol-1-yl)butanenitrile;

1′-{[5-Chloro-1-(4-fluorobutyl)-1H-indol-2-yl]methyl}-1-(2-hydroxy-2-methylpropanoyl)spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

4-(5-Chloro-2-{[1-(2-hydroxy-2-methylpropanoyl)-2′-oxospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-1′(2′H)-yl]methyl}-1H-benzimidazol-1-yl)butanenitrile;

4-{5-Chloro-2-[(1′,1′-dioxido-2-oxo-2′,3′,5′,6′-tetrahydrospiro[pyrrolo[2,3-c]pyridine-3,4′-thiopyran]-1(2H)-yl)methyl]-1H-benzimidazol-1-yl}butanenitrile;

4-{5-Chloro-2-[(3-hydroxy-2′-oxospiro[cyclobutane-1,3′-indol]-1′(2′H)-yl)methyl]-1H-benzimidazol-1-yl}butanenitrile;

4-(5-chloro-2-(((1S,3S)-1′-((5-chloro-1-(3-cyanopropyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxospiro[cyclobutane-1,3′-indoline]-3-yloxy)methyl)-1H-benzo[d]imidazol-1-yl)butanenitrile;

1′-{[5-Chloro-1-(4-fluorobutyl)-1H-indol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-sulfonamide;

4-(5-Chloro-2-{[1-(cyclopropylsulfonyl)-2′-oxospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-1′(2′H)-yl]methyl}-1H-benzimidazol-1-yl)butanenitrile;

tert-Butyl 2′-oxo-1′-{[1-(4,4,4-trifluorobutyl)-1H-indol-2-yl]methyl}-1′,2′-dihydro-1H-spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

N-[(1′-{[5-Chloro-1-(4-fluorobutyl)-1H-indol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-1-yl)sulfonyl]acetamide;

Diethyl (1′-{[5-chloro-1-(3-cyanopropyl)-1H-benzimidazol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-1-yl)phosphonate;

4-(5-Chloro-2-{[2′-oxo-1-(3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl)spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-1′(2′H)-yl]methyl}-1H-benzimidazol-1-yl)butanenitrile;

N-[(1′-{[5-Chloro-1-(3-cyanopropyl)-1H-indol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[azetidine-3,3′-indol]-1-yl)sulfonyl]acetamide;

(1r,3r)-1′-((5-chloro-1-(4-fluorobutyl)-1H-indol-2-yl)methyl)-2′-oxospiro[cyclobutane-1,3′-indolin]-3-ylmethylcarbamate;

(R)-1-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-1′-(2-hydroxy-2-methylpropanoyl)spiro[indole-3,3′-pyrrolidin]-2(1H)-one;

(S)-1-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-1′-(2-hydroxy-2-methylpropanoyl)spiro[indoline-3,3′-pyrrolidin]-2-one;

(1r,3r)-1′-((5-chloro-1-(3-cyanopropyl)-1H-indol-2-yl)methyl)-2′-oxospiro[cyclobutane-1,3′-indolin]-3-ylmethylcarbamate;

cyclopropyl ((1s,3s)-1′-((5-chloro-1-(3-cyanopropyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxospiro[cyclobutane-1,3′-indolin]-3-yl)carbamate;

cyclopropyl ((1r,3r)-1′-((5-chloro-1-(3-cyanopropyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxospiro[cyclobutane-1,3′-indolin]-3-yl)carbamate;

(S)-4-(5-chloro-2-((1-(2,3-dihydroxypropanoyl)-2′-oxospiro[azetidine-3,3′-indolin]-1′-yl)methyl)-1H-indol-1-yl)butanenitrile;

(R)-4-(5-chloro-2-((1-(2,3-dihydroxypropanoyl)-2′-oxospiro[azetidine-3,3′-indolin]-1′-yl)methyl)-1H-indol-1-yl)butanenitrile;

Cyclopropyl 1′-{[5-chloro-1-(3-cyanopropyl)-1H-indol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

(1r,3r)-1′-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxospiro[cyclobutane-1,3′-indolin]-3-ylmorpholine-4-carboxylate;

1′-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)spiro[azetidine-3,3′-indol]-2′(1′H)-one;

methyl ((1s,3s)-1′-((5-chloro-1-(3-cyanopropyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxospiro[cyclobutane-1,3′-indolin]-3-yl)carbamate;

methyl ((1r,3r)-1′-((5-chloro-1-(3-cyanopropyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxospiro[cyclobutane-1,3′-indolin]-3-yl)carbamate;

4-[5-Chloro-2-({1-[(1-hydroxycyclopropyl)carbonyl]-2′-oxospiro[azetidine-3,3′-indol]-1′(2′H)-yl}methyl)-1H-indol-1-yl]butanenitrile;

1-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)methyl)-1′-(2-hydroxy-2-methylpropanoyl)spiro[indoline-3,3′-pyrrolidin]-2-one;

1-((1s,3s)-1′-((5-chloro-1-(3-cyanopropyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxospiro[cyclobutane-1,3′-indolin]-3-yl)-3-isopropylurea;

1-((1r,3r)-1′-((5-chloro-1-(3-cyanopropyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxospiro[cyclobutane-1,3′-indolin]-3-yl)-3-isopropylurea;

N-((1s,3s)-1′-((5-chloro-1-(3-cyanopropyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxospiro[cyclobutane-1,3′-indolin]-3-yl)acetamide;

N-((1r,3r)-1′-((5-chloro-1-(3-cyanopropyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxospiro[cyclobutane-1,3′-indolin]-3-yl)acetamide;

2-Hydroxyethyl 1′-{[5-chloro-1-(3-cyanopropyl)-1H-indol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

4-(2-(((1r,3r)-3-amino-2′-oxospiro[cyclobutane-1,3′-indolin]-1′-yl)methyl)-5-chloro-1H-benzo[d]imidazol-1-yl)butanenitrile;

4-(2-(((1s,3s)-3-amino-2′-oxospiro[cyclobutane-1,3′-indolin]-1′-yl)methyl)-5-chloro-1H-benzo[d]imidazol-1-yl)butanenitrile;

2-(Acetyloxy)ethyl 1′-{[5-chloro-1-(3-cyanopropyl)-1H-indol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

1′-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2-hydroxy-2-methylpropanoyl)spiro[azetidine-3,3′-indol]-2′(1′H)-one;

5-Chloro-1-(4-fluorobutyl)-2-{[1-(2-hydroxy-2-methylpropanoyl)-2′-oxospiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-1′(2′H)-yl]methyl}-1H-indole-3-carboxamide;

4-(5-Chloro-2-{[1′-(2-hydroxy-2-methylpropanoyl)-2-oxospiro[indole-3,3′-pyrrolidin]-1(2H)-yl]methyl}-1H-benzimidazol-1-yl)butanenitrile;

1′-{[5-Chloro-1-(4-hydroxybutyl)-1H-indol-2-yl]methyl}-1-(2-hydroxy-2-methylpropanoyl)spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

tert-Butyl 1′-{[3-carbamoyl-5-chloro-1-(4-fluorobutyl)-1H-indol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

tert-Butyl 1-{[5-chloro-1-(3-cyanopropyl)-1H-benzimidazol-2-yl]methyl}-2-oxo-1,2-dihydro-1′H-spiro[indole-3,3′-pyrrolidine]-1′-carboxylate;

1′-{[5-Chloro-1-(4-fluorobutyl)-1H-benzimidazol-2-yl]methyl}-3H-spiro[cyclobutane-1,3′-indole]-2′,3(1′H)-dione;

1′-{[5-Chloro-1-(4-fluorobutyl)-1H-indol-2-yl]methyl}spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

tert-Butyl 1′-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-2′-oxo-1′,2′-dihydro-1H-spiro[azetidine-3,3′-indole]-1-carboxylate;

1′-{[5-Chloro-1-(4-hydroxybutyl)-1H-benzimidazol-2-yl]methyl}-1-(2-hydroxy-2-methylpropanoyl)spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

4-(5-chloro-2-((1-(2,3-dihydroxypropanoyl)-2′-oxospiro[azetidine-3,3′-indolin]-1′-yl)methyl)-1H-indol-1-yl)butanenitrile;

1′-{[5-Chloro-1-(4-hydroxybutyl)-1H-indol-2-yl]methyl}-1-(2-hydroxy-2-methylpropanoyl)spiro[azetidine-3,3′-indol]-2′(1′H)-one;

1′-{[5-Chloro-1-(4-fluorobutyl)-1H-indol-2-yl]methyl}-dihydroxypropanoyl)spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

(1r,3r)-1′-((5-chloro-1-(3-cyanopropyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxospiro[cyclobutane-1,3′-indolin]-3-ylmethylcarbamate;

1′-{[5-Chloro-1-(4-fluorobutyl)-1H-benzimidazol-2-yl]methyl}-1-(2-hydroxy-2-methylpropanoyl)spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

N-[(1′-{[5-Chloro-1-(3-cyanopropyl)-1H-benzimidazol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[azetidine-3,3′-indol]-1-yl)sulfonyl]acetamide;

N-[(1′-{[5-Chloro-1-(3-cyanopropyl)-1H-indol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-1-yl)sulfonyl]acetamide;

(1r,3r)-1′-((5-chloro-1-(3-cyanopropyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxospiro[cyclobutane-1,3′-indolin]-3-ylcyclopropylcarbamate;

1′-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-2,6-dimethyl-2,3,5,6-tetrahydrospiro[pyran-4,3′-pyrrolo[2,3-c]pyridin]-2′(1′H)-one;

1′-{[5-Chloro-1-(4-hydroxybutyl)-1H-benzimidazol-2-yl]methyl}-1-(2-hydroxy-2-methylpropanoyl)spiro[azetidine-3,3′-indol]-2′(1′H)-one;

4-(5-chloro-2-(((1r,3r)-3-hydroxy-2′-oxospiro[cyclobutane-1,3′-indolin]-1′-yl)methyl)-1H-benzo[d]imidazol-1-yl)butanenitrile;

Methyl 1′-{[5-chloro-1-(4-fluorobutyl)-1H-benzimidazol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

1-Methylethyl 1′-{[5-chloro-1-(4-fluorobutyl)-1H-benzimidazol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridine]-1-carboxylate;

4-(5-Chloro-2-{[1-(cyclopropylsulfonyl)-2′-oxospiro[azetidine-3,3′-indol]-1′(2′H)-yl]methyl}-1H-benzimidazol-1-yl)butanenitrile;

4-[5-Chloro-2-({2′-oxo-1-[3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propanoyl]spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-1′(2′H)-yl}methyl)-1H-benzimidazol-1-yl]butanenitrile;

1′-{[5-Chloro-1-(4-fluorobutyl)-1H-benzimidazol-2-yl]methyl}-1-(2-hydroxy-2-methylpropanoyl)spiro[azetidine-3,3′-indol]-2′(1′H-one; and

N-[(1′-{[5-Chloro-1-(4-fluorobutyl)-1H-indol-2-yl]methyl}-2′-oxo-1′,2′-dihydro-1H-spiro[piperidine-4,3′-pyrrolo[2,3-c]pyridin]-1-yl)sulfonyl]cyclopropanecarboxamide;

and pharmaceutically acceptable addition salts or solvates thereof.

14. The compound as claimed in claim 1 , wherein the compound is

or a pharmaceutically acceptable addition salt or a solvate thereof.

15. A pharmaceutical composition comprising a pharmaceutically acceptable carrier, and a compound as claimed in claim 14 .

16. A method for treating a viral RSV infection comprising administering to a subject in need thereof, a therapeutically effective amount of a compound as claimed in claim 14 .

17. A method for treating a viral RSV infection comprising administering to a subject in need thereof, a therapeutically effective amount of a composition as claimed in claim 15 .