Wound dressings comprising a plurality of liquid-expandable articles
Provided herein are self-expanding wound dressings that include a first outer layer, a second outer layer, and a liquid-expandable layer disposed between the first outer layer and the second outer layer, wherein the liquid-expandable layer includes a plurality of liquid-expandable articles retained by a substrate, wherein the plurality of liquid-expandable articles expand to form expanded articles upon contact with a liquid. Also provided is a method of treating an individual having a bleeding wound, the method including applying a self-expanding wound dressing to the wound. Also provided are methods of manufacturing a wound dressing, the methods including forming an absorbent material into a plurality of liquid-expandable articles, coupling the plurality of liquid-expandable articles to a substrate to form a liquid-expandable layer, and positioning the liquid-expandable layer between a first outer layer and a second outer layer to form the wound dressing.
1. A wound dressing, comprising:
a first outer layer;
a second outer layer; and
a liquid-expandable layer positioned between the first outer layer and the second outer layer, wherein the liquid-expandable layer comprises a plurality of liquid-expandable articles each independently attached to a backing layer,
wherein the backing layer is in sheet form,
wherein the backing layer has a first major surface, and second, opposing major surface and the plurality of liquid-expandable articles is attached to the first major surface and arranged in a predetermined pattern on the backing layer, wherein attachment points of the liquid-expandable articles to the backing layer are substantially coplanar with each other,
wherein the plurality of liquid-expandable articles expand away from the first major surface of the backing layer to form expanded articles upon contact with a liquid,
wherein the expanded articles have a lateral dimension and a longitudinal dimension and expansion of the plurality of liquid-expandable articles is principally along the longitudinal dimension.
2. The wound dressing of claim 1 , wherein at least one of the first outer layer and second outer layer comprises a porous material.
3. The wound dressing of claim 1 , wherein the first outer layer and second outer layer are joined to form one or more pockets to receive the liquid-expandable layer therein.
4. The wound dressing of claim 1 , wherein the plurality of liquid-expandable articles comprises compressed sponge.
5. The wound dressing of claim 4 , wherein the compressed sponge comprises regenerated cellulose.
6. The wound dressing of claim 1 , wherein the liquid-expandable articles comprise a substantially cylindrical shape.
7. The wound dressing of claim 1 , wherein the liquid-expandable articles in the predetermined pattern are spaced sufficiently far apart so that the wound dressing remains flexible.
8. The wound dressing of claim 1 , wherein the predetermined pattern defines one or more regions without liquid-expandable articles.
9. The wound dressing of claim 1 , wherein the liquid-expandable articles expand to 80% or greater of their maximum expansion capacity within 30 seconds following immersion in water or saline.
10. The wound dressing of claim 9 , wherein the volume ratio of expanded articles to liquid-expandable articles is at least 4:1.
11. The wound dressing of claim 1 , wherein the first outer layer, the second outer layer and the liquid-expandable layer are laminated to form an elongated sheet.
12. The wound dressing of claim 1 , wherein a pre-expansion volume of each liquid-expandable article is from 0.7 mm 3 to 7000 mm 3 .
13. The wound dressing of claim 1 , further comprising one or more therapeutic agents coupled to at least one of the first outer layer, the second outer layer and the liquid-expandable layer.
14. The wound dressing of claim 1 , further comprising a second plurality of liquid-expandable articles attached to the second major surface.