IP Library › Granted Patent US 9,629,888
Granted Patent B2
US 9,629,888 · App. 13/582,655 · Granted Apr 25, 2017

Composition of matter for delivering lipid-soluble materials, and a method for producing it

Inventors: Yangming Martin Lo (Ashton, MD); Ansu Elizabeth Cherian (Washington, DC); Neil Allen Belson (Port Tobacco, MD)
Assignees: LeafPro, LLC; University of Maryland, College Park
A61K36/81A23L33/155A23L33/185A61K9/146A61K9/148A61K36/21A61K36/47A61K47/42A61K47/46A23V2002/00A61K38/00
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Quick Facts
Patent No.
US 9,629,888
App. No.
13/582,655
Granted
Apr 25, 2017
Kind
B2
Abstract

This invention describes a novel composition of matter describing a complex comprising leaf protein and a lipophilic substance(s), along with the method of producing it. Delivery of lipid-soluble materials into the body is challenging because they are generally highly insoluble in water and very subject to oxidative degradation. The inventors have found that leaf protein—the water-soluble proteins derived from plant leaves—can efficiently form a complex with lipophilic materials. This leaf protein—lipid-soluble material complex is an effective carrier of lipophilic substances. As such, the leaf protein—lipid-soluble material complex disclosed herein can be used for the delivery of lipophilic vitamins, fatty acids, caretenoids, lipophilic drugs, and other lipophilic materials. This complex can be used to deliver lipophiles in foods, nutritional and dietary supplements, topical compositions and in pharmaceutical products.

Claims (8)

1. A freeze-dried or spray-dried powder composition comprising one or more of the vitamins A, D, D2, D3, E or K, bound to a carrier consisting of leaf protein extracted from tobacco, alfalfa or spinach leaves.

2. The freeze-dried or spray-dried powder composition according to claim 1 wherein the composition is a food or food ingredient intended for human consumption.

3. A dietary supplement, nutritional supplement, or nutraceutical comprising the composition of claim 1 .

4. A product intended for consumption by mammals other than humans comprising the composition of claim 1 .

5. A topical composition comprising the freeze-dried or spray-dried composition of claim 1 , and a pharmaceutically acceptable topical carrier.

6. The freeze-dried or spray-dried powder composition according to claim 1 wherein the leaf protein constitutes at least 20% of the composition.

7. The freeze-dried or spray-dried powder composition of claim 1 , wherein said composition is produced by (a) providing a suspension comprising extracted leaf protein in a solvent; (b) combining the leaf protein suspension with one or more of vitamins A, D, D2, D3, E or K (c) allowing the leaf protein to bind with the one or more of vitamins A, D, D2, D3, E or K, and (d) forming the composition into a powder, tablet, capsule, gel-cap, elixir or effervescent tablet.

8. The freeze-dried or spray-dried powder of claim 1 , wherein the leaf protein is crude leaf protein and comprises about 30% of the composition.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 5, 2016
From: NEWAGRICULTURE, INC
To: LEAFPRO, LLC
Reel/Frame 037414/0853 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 18, 2013
From: BELSON, NEIL A.
To: NEW AGRICULTURE, INC.
Reel/Frame 029824/0055 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 18, 2013
From: CHERIAN, ANSU ELIZABETH
To: UNIVERSITY OF MARYLAND, COLLEGE PARK
Reel/Frame 029824/0338 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 18, 2013
From: LO, YANGMING MARTIN
To: UNIVERSITY OF MARYLAND, COLLEGE PARK
Reel/Frame 029824/0414 →
Continuity (2)
Provisional Application 61311072 · Mar 5, 2010
Related Publication 20130059795A1 · Mar 7, 2013