Use of Th9 cells and IL-9 for the treatment of melanoma
Described herein are methods for the treatment of cancer (e.g. melanoma, lung cancer, or other cancers). The methods involve administrating to a subject in need thereof an agonist of the IL-9 receptor (e.g. IL-9), e.g. an agent that binds and activates the IL-9 receptor, or an agent that increases IL-9 expression in the subject (e.g. administration of TH9 cells that express IL-9, or administration of an inhibitor of ROR).
1. A method for treating melanoma in a subject comprising administering to a subject in need thereof a therapeutically effective amount of an agonist of an interleukin-9 receptor (IL-9R), wherein the agonist of IL9-R comprises a population of Th9 cells or an IL-9 polypeptide, wherein the IL-9 polypeptide is selected from the group consisting of: SEQ ID NO: 2, amino acids 19-144 of SEQ ID NO: 2, SEQ ID NO: 15 and SEQ ID NO: 16.
2. The method of claim 1 , wherein the agonist further comprises a pharmaceutically acceptable carrier.
3. The method of claim 1 , wherein the subject is human.
4. The method of claim 1 , wherein the agonist is administered by a route selected from the group consisting of: intratumor, adoptive cell transfer, and parenteral administration.