Dynamic multi organ plate

1. A dynamic multi-organ plate comprising,

two or more wells, wherein the wells are configured for cell or tissue culture growth;

at least one transwell tube in fluid communication with the two or more wells; and

a pump in fluid communication with the at least one transwell tube;

wherein each well independently comprises an outer shell and an insert, wherein the insert forms a hollow interior, into which the cell or tissue culture is placed;

wherein a space for fluid exists between the outer shell and the insert, wherein as more fluid is introduced into the system, the fluid space becomes larger while the insert shrinks;

wherein the insert comprises a semipermeable wall that allows for diffusion of chemicals, gasses, and fluids between the fluid space and the interior of the well;

wherein the fluid in the well is in contact with at least a portion of the semipermeable wall of the insert; and

wherein the hollow interior of each insert is not in direct fluid communication with a transwell tube.

2. The plate of claim 1 , wherein:

a first transwell tube connects the pump with a first well;

a second transwell tube connects the first well with a second well; and

a third transwell tube connects the second well with the pump.

3. The plate of claim 1 , wherein the flow of fluid into and out of a well is unidirectional.

4. The plate of claim 1 , wherein the flow of fluid into and out of a well is bidirectional.

5. The plate of claim 1 , wherein the wall of the transwell tube is polarized and provide a one-way flow of fluids or nutrients across the transwell tube wall.

6. The plate of claim 1 , wherein the wells and the transwell tubes are prefabricated onto the plate.

7. The plate of claim 1 , wherein the wells and the transwell tubes are arranged on the plate by a user.

8. The plate of claim 1 , wherein a transwell tube comprises a well port, through which a substance is introduced into the transwell tube lumen, or through which an aliquot of a fluid within the transwell tube lumen is removed.

9. The plate of claim 8 , wherein the substance is a small organic molecule or a protein.

10. The plate of claim 1 , wherein heart tissue is present in one well, wherein the well comprises a microarray electrode configure to measure the electrical activity of the heart tissue.

11. The plate of claim 1 , wherein the fluid space is in fluid communication with the transwell tubes.

12. The plate of claim 1 , wherein one well comprises lung tissue.

13. The plate of claim 12 , wherein the lung well further comprises a chamber, fitted over the lung well.

14. The plate of claim 13 , wherein the chamber comprises an opening configured for an operator to introduce fluids or other substances into the chamber.

15. The plate of claim 1 , wherein the transwell tube comprises a dialysis membrane.

16. A dynamic multi-organ plate comprising,

two or more wells, wherein the wells are configured for cell or tissue culture growth;

at least one channel between the two or more wells configured to provide fluid communication between the two or more wells; and

a pump in fluid communication with the at least one channel; wherein each well independently comprises an outer shell and an insert, wherein the insert forms a hollow interior, into which the cell or tissue culture is placed;

wherein a space for fluid exists between the outer shell and the insert, wherein as more fluid is introduced in the system, the fluid space becomes larger while the insert shrinks;

wherein the insert comprises a semipermeable wall that allows for diffusion of chemicals, gasses, and fluids between the fluid space and the interior of the well;

wherein the fluid in the well is in contact with at least a portion of the semipermeable wall of the insert; and

wherein the hollow interior of each insert is not in direct fluid communication with a channel.

17. The plate of claim 16 , wherein the channel is an open channel.

18. The plate of claim 16 , wherein the channel is a closed channel.