Method of treating cancer
The invention provides a method for treating cancer using a coadministration strategy that combines local codelivery of a therapeutic agent and an intracellular penetration enhancing agent, and optionally in further combination with local administration of an immunotherapeutic agent, such as a cancer vaccine or NKT agonist. The invention also provides a method for treating cancer using an intracellular penetration enhancing agent. The methods of the invention aim to substantially kill and/or destroy the target tumor cells, as well as those cancerous cells that have metastasized to other parts of the body.
1. A method of treating cancer in a subject in need of treatment, wherein the method comprises intratumorally administering a pharmaceutical composition comprising a solution, the solution comprising a therapeutically effective amount of a therapeutic agent and an intracellular permeation enhancing agent, wherein the intracellular permeation enhancing agent facilitates the intracellular transport of the therapeutic agent across an intact cell membrane of the tumor and does not have therapeutic activity, wherein the therapeutic agent is not associated with a liposomal vesicle and is a chemotherapeutic agent, an interfering RNA, a therapeutic protein or a therapeutic antibody and the therapeutic agent is not covalently bound to the intracellular permeation enhancing agent, and wherein the intracellular permeation enhancing agent is selected from the group consisting of 6-Oxo-6-phenylhexanoic acid, 8-Cyclohexyl-8-oxooctanoic acid, N-[8-(2-hydroxybenzoyl)aminooctanoic acid, a functionally effective salt of any of the foregoing, and any combination thereof.
2. The method of claim 1 , wherein the therapeutic agent is cisplatin or other platinum agent, and wherein the intracellular permeation enhancing agent is 6-oxo-6 phenylhexanoic acid, N-[8-(2-hydroxybenzoyl)aminooctanoic acid, or a functionally effective salt thereof and the other platinum agent is satraplatin, picoplatin, nedaplatin, triplatin, carboplatin or oxaplatin.