Pyridine derivative

1. A pyridine derivative represented by the following formula (I) or a pharmaceutically acceptable salt thereof,

wherein:

A represents a single bond;

R 1 represents a nitrogen atom, X 2 is N; X 1 , X 3 , X 4 and X 5 are CR 2 ;

R 2 each independently represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, an alkynyl group having 2 to 6 carbon atoms, a halogen atom, a trifluoromethyl group, a difluoromethyl group, a cyano group, an alkylcarbonyl group having 2 to 7 carbon atoms, an alkylsulfonyl group having 1 to 6 carbon atoms, a nitro group, an amino group, a dialkylamino group having 1 to 6 carbon atoms, a formyl group, a hydroxyl group, an alkoxy group having 1 to 6 carbon atoms (which may optionally be substituted with one or more of a hydroxyl group, a phenyl group, a cyclohexyl group, and a halogen atom), an alkylthio group having 1 to 6 carbon atoms, a phenyl group (which may optionally be substituted with one or more of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, and a halogen atom), or a phenoxy group (which may optionally be substituted with one or more of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, and a halogen atom);

R 3 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms (which may optionally be substituted with one or more of a hydroxyl group, an amino group, a dialkylamino group having 1 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, an alkynyl group having 2 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms (which may optionally be substituted with one or more of a hydroxyl group and a halogen atom), an alkylcarbonyl group having 2 to 7 carbon atoms, an alkylthio group having 1 to 6 carbon atoms, an alkylsulfinyl group having 1 to 6 carbon atoms, a halogen atom, a trifluoromethyl group, a difluoromethyl group, a cyano group, a phenyl group (which may optionally be substituted with one or more of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, and a halogen atom), a phenoxy group (which may optionally be substituted with one or more of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, and a halogen atom), a carboxyl group, or —CO 2 R 5 ;

R 4 represents a carboxyl group, —CONHSO 2 R 5 , —CO 2 R 5 , or any of the following substituents:

R 5 in R 3 and R 4 each independently represents an alkyl group having 1 to 6 carbon atoms;

Z represents any of the following substituents designated Z1 to Z2:

wherein:

R 6 and R 7 each independently represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms, a trifluoromethyl group, a trifluoromethoxy group, or a cyano group, with the proviso that the case where R 6 and R 7 are simultaneously hydrogen atoms is excluded;

R 8 represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms, or a trifluoromethyl group; and

Y represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms.

2. The pyridine derivative or the pharmaceutically acceptable salt thereof, according to claim 1 , wherein, among four CR 2 's, three are CH's and R 2 of the remaining one CR 2 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a halogen atom, a trifluoromethyl group, a difluoromethyl group, a cyano group, a nitro group, a dialkylamino group having 1 to 6 carbon atoms a hydroxyl group, an alkoxy group having 1 to 6 carbon atoms (which may optionally be substituted with one or more of a hydroxyl group, a phenyl group, a cyclohexyl group, and a halogen atom), an alkylthio group having 1 to 6 carbon atoms, a phenyl group (which may optionally be substituted with one or more of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, and a halogen atom), or a phenoxy group (which may optionally be substituted with one or more of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, and a halogen atom).

3. The pyridine derivative or the pharmaceutically acceptable salt thereof, according to claim 2 , wherein R 2 is a hydrogen atom, a methyl group, an ethyl group, a cyclopropyl group, a methoxy group, an ethoxy group, a propoxy group, an isopropoxy group, an isobutyloxy group, a benzyloxy group, a methylthio group, a fluorine atom, a chlorine atom, a bromine atom, a cyano group, a hydroxyl group, a trifluoromethyl group, a difluoromethyl group, a nitro group, a phenyl group, or a phenoxy group.

4. The pyridine derivative or the pharmaceutically acceptable salt thereof according to claim 1 , wherein, among four CR 2 's, three are CH's and the remaining CR 2 is located at X 4 .

5. The pyridine derivative or the pharmaceutically acceptable salt thereof, according to claim 1 , wherein R 3 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms (which may optionally be substituted with one or more of a hydroxyl group, an amino group, a dialkylamino group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, an alkylthio group having 1 to 6 carbon atoms, a halogen atom, a trifluoromethyl group, a difluoromethyl group, a cyano group, a phenyl group (which may optionally be substituted with one or more of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, and a halogen atom), a carboxyl group, or —CO 2 R 5 .

6. The pyridine derivative or the pharmaceutically acceptable salt thereof, according to claim 5 , wherein R 3 is a hydrogen atom, a methyl group, an ethyl group, an isopropyl group, a cyclopropyl group, a chlorine atom, a bromine atom, an iodine atom, a trifluoromethyl group, a difluoromethyl group, a methoxy group, a phenyl group, a cyano group, a carboxyl group, —CO 2 R 5 , a hydroxymethyl group, a 1-hydroxyethyl group, a 2-hydroxypropan-2-yl group, a 3-hydroxypentan-3-yl group, a dimethylaminomethyl group, or a diethylaminomethyl group.

7. The pyridine derivative or the pharmaceutically acceptable salt thereof, according to claim 1 , wherein R 4 is a carboxyl group —CONHSO 2 CH 3 , —CONHSO 2 -cyclopropyl, or —CO 2 R 5 .

8. The pyridine derivative or the pharmaceutically acceptable salt thereof, according to claim 1 , wherein Z is Z1, and R 6 and R 7 are, on a phenyl ring, chlorine substituents at 2- and 5-positions, chlorine substituents at 3- and 5-positions, methyl substituents at 2- and 5-positions, trifluoromethyl substituents at 2- and 5-positions, or chlorine and methyl substituents at 2- and 5-positions, respectively; or

Z is Z2, and R 8 is, on a naphthalene ring, a hydrogen atom, a 2-methyl group, a 4-methyl group, an 8-methyl group, or an 8-bromo group.

9. A pyridine derivative selected from the following compounds (1) to (193) or a pharmaceutically acceptable salt thereof:

(1) 1-(2,5-dimethylbenzyl)-4-methyl-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(2) 4-methyl-1-(naphthalen-1-ylmethyl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(3) ethyl 4-methyl-1-(naphthalen-1-ylmethyl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylate;

(7) 4-chloro-1-(naphthalen-1-ylmethyl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(8) 4-ethyl-1-(naphthalen-1-ylmethyl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(9) 4-cyclopropyl-1-(naphthalen-1-ylmethyl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(10) 1-(2,5-dichlorobenzyl)-4-methyl-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(11) 1-(2,5-dichlorobenzyl)-4-ethyl-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(12) 4-cyclopropyl-1-(2,5-dichlorobenzyl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(13) 4-methyl-1-((4-methylnaphthalen-1-yl) methyl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(14) 4-cyclopropyl-1-((4-methylnaphthalen-1-yl)methyl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(15) 1-(2,5-dichlorobenzyl)-2-(pyridin-3-yl)-4-(trifluoromethyl)-1H-imidazole-5-carboxylic acid;

(17) 4-chloro-1-((4-methylnaphthalen-1-yl)methyl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(18) 4-isopropyl-1-(naphthalen-1-ylmethyl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(19) 4-isopropyl-1-((4-methylnaphthalen-1-yl)methyl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(20) 1-(2,5-dichlorobenzyl)-4-isopropyl-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(31) 1-(2-chloro-5-fluorobenzyl)-4-methyl-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(32) 1-(5-chloro-2-fluorobenzyl)-4-methyl-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(33) 1-(2-chloro-5-(trifluoromethyl)benzyl)-4 methyl-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(34) 1-(5-chloro-2-(trifluoromethyl)benzyl)-4-methyl-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(35) 1-(2,5-dichlorobenzyl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(36) 1-(2,5-bis(trifluoromethyl)benzyl)-4-methyl-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(37) 1-(2-bromobenzyl)-4-methyl-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(38) 1-(3-bromobenzyl)-4-methyl-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(40) 1-(3,4-dichlorobenzyl)-4-methyl-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(41) 1-(2,3-dichlorobenzyl)-4-methyl-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(42) 1-(3,5-dichlorobenzyl)-4-methyl-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(43) 1-(3-chloro-5-fluorobenzyl)-4-methyl-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(44) 1-(2,4-dichlorobenzyl)-4-methyl-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(45) 1-(2-chloro-5-methylbenzyl)-4-methyl-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(54) 4-chloro-1-(2,5-dichlorobenzyl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(55) 4-bromo-1-(2,5-dichlorobenzyl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(56) 1-(2,5-dichlorobenzyl)-4-iodo-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(57) 1-(2,5-dichlorobenzyl)-4-phenyl-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(58) 1-(2,5-dichlorobenzyl)-4-(3-fluorophenyl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(59) 1-(2,5-dichlorobenzyl)-4-(4-fluorophenyl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(61) 1-(2,5-dichlorobenzyl)-4-methoxy-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(62) 1-(2,5-dichlorobenzyl)-2-(pyridin-3-yl)-4-(2,2,2-trifluoroethoxy)-1H-imidazole-5-carboxylic acid;

(63) 1-(2,5-dichlorobenzyl)-2-(pyridin-3-yl)-4-(p-tolyloxy)-1H-imidazole-5-carboxylic acid;

(64) 1-(2,5-dichlorobenzyl)-4-(4-fluorophenoxy)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(65) 4-cyano-1-(2,5-dichlorobenzyl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(66) 1-(2,5-dichlorobenzyl)-2-(pyridin-3-yl)-4-vinyl-1H-imidazole-5-carboxylic acid;

(67) 4-(1-cyclopenten-1-yl)-1-(2,5-dichlorobenzyl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(68) 1-(2,5-dichlorobenzyl)-4-(methylthio)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(69) 1-(2,5-dichlorobenzyl)-4-(ethylthio)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(70) 1-(2,5-dichlorobenzyl)-4-(2-hydroxypropan-2-yl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(71) 1-(2,5-dichlorobenzyl)-4-(3-hydroxypentan-3-yl)-2-(pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(75) 2-(5-fluoropyridin-3-yl)-4-methyl-1-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxylic acid;

(76) 2-(5-chloropyridin-3-yl)-4-methyl-1-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxylic acid;

(77) 4-methyl-1-(naphthalen-1-ylmethyl)-2-(5-phenoxypyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(80) 1-(2,5-dichlorobenzyl)-2-(5-fluoropyridin-3-yl)-4-methyl-1H-imidazole-5-carboxylic acid;

(81) 2-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-methyl-1H-imidazole-5-carboxylic acid;

(82) 1-(2,5-dichlorobenzyl)-2-(5-fluoropyridin-3-yl)-4-(trifluoromethyl)-1H-imidazole-5-carboxylic acid;

(83) 2-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-(trifluoromethyl)-1H-imidazole-5-carboxylic acid;

(84) 4-methyl-1-(naphthalen-1-ylmethyl)-2-(5-(trifluoromethyl)pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(85) 1-(2,5-dichlorobenzyl)-4-methyl-2-(5-(trifluoromethyl)pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(86) 1-(2,5-dichlorobenzyl)-4-(trifluoromethyl)-2-(5-(trifluoromethyl)pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(90) 2-(5-chloropyridin-3-yl)-4-isopropyl-1-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxylic acid;

(91) 2-(5-chloropyridin-3-yl)-4-cyclopropyl-1-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxylic acid;

(92) 2-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-isopropyl-1H-imidazole-5-carboxylic acid;

(93) 2-(5-chloropyridin-3-yl)-4-cyclopropyl-1-(2,5-dichlorobenzyl)-1H-imidazole-5-carboxylic acid;

(94) 4-ethyl-2-(5-fluoropyridin-3-yl)-1-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxylic acid;

(95) 2-(5-chloropyridin-3-yl)-4-ethyl-1-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxylic acid;

(96) 1-(2,5-dichlorobenzyl)-4-ethyl-2-(5-fluoropyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(97) 2-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-ethyl-1H-imidazole-5-carboxylic acid;

(98) 2-(5-fluoropyridin-3-yl)-4-isopropyl-1-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxylic acid;

(99) 4-cyclopropyl-2-(5-fluoropyridin-3-yl)-1-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxylic acid;

(100) 1-(2,5-dichlorobenzyl)-2-(5-fluoropyridin-3-yl)-4-isopropyl-1H-imidazole-5-carboxylic acid;

(101) 4-cyclopropyl-1-(2,5-dichlorobenzyl)-2-(5-fluoropyridin-3-yl)-H-imidazole-5-carboxylic acid;

(102) 1-(2,5-dichlorobenzyl)-4-methyl-2-(5-methylpyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(103) 1-(2,5-dichlorobenzyl)-2-(5-methoxypyridin-3-yl)-4-methyl-1H-imidazole-5-carboxylic acid;

(104) 2-(5-cyanopyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-methyl-1H-imidazole-5-carboxylic acid;

(105) 1-(2,5-dichlorobenzyl)-4-methyl-2-(6-methylpyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(106) 1-(2,5-dichlorobenzyl)-2-(2-fluoropyridin-3-yl)-4-methyl-1H-imidazole-5-carboxylic acid;

(107) 1-(2,5-dichlorobenzyl)-2-(6-methoxypyridin-3-yl)-4-methyl-1H-imidazole-5-carboxylic acid;

(108) 1-(2,5-dichlorobenzyl)-2-(2-methoxypyridin-3-yl)-4-methyl-1H-imidazole-5-carboxylic acid;

(109) 2-(6-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-methyl-1H-imidazole-5-carboxylic acid;

(111) 1-(2,5-dichlorobenzyl)-4-methyl-2-(5-nitropyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(112) 2-(5-cyclopropylpyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-methyl-1H-imidazole-5-carboxylic acid;

(113) 2-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-1H-imidazole-5-carboxylic acid;

(114) 1-(2,5-bis(trifluoromethyl)benzyl)-2-(5-fluoropyridin-3-yl)-4-methyl-1H-imidazole-5-carboxylic acid;

(115) 1-(2,5-dichlorobenzyl)-2-(5-fluoropyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(116) 1-(2,5-dichlorobenzyl)-2-(5-hydroxypyridin-3-yl)-4-methyl-1H-imidazole-5-carboxylic acid;

(117) 1-(2,5-bis(trifluoromethyl)benzyl)-2-(5-chloropyridin-3-yl)-4-methyl-1H-imidazole-5-carboxylic acid;

(118) 1-(2,5-dichlorobenzyl)-2-(5-ethoxypyridin-3-yl)-4-methyl-1H-imidazole-5-carboxylic acid;

(119) 1-(2,5-dichlorobenzyl)-2-(5-isopropoxypyridin-3-yl)-4-methyl-1H-imidazole-5-carboxylic acid;

(120) 1-(2,5-dichlorobenzyl)-4-methyl-2-(5-phenylpyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(121) 2-(5-bromopyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-methyl-1H-imidazole-5-carboxylic acid;

(122) 1-(2,5-dimethylbenzyl)-2-(5-fluoropyridin-3-yl)-4-methyl-1H-imidazole-5-carboxylic acid;

(123) 2-(5-chloropyridin-3-yl)-1-(2,5-dimethylbenzyl)-4-methyl-1H-imidazole-5-carboxylic acid;

(124) 1-(2,5-dimethylbenzyl)-4-methyl-2-(5-methylpyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(125) 1-(2,5-dichlorobenzyl)-2-(5-ethylpyridin-3-yl)-4-methyl-1H-imidazole-5-carboxylic acid;

(126) 1-(2,5-dichlorobenzyl)-4-methyl-2-(5-(methylthio)pyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(127) 2-(5-acetylpyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-methyl-1H-imidazole-5-carboxylic acid;

(128) 1-(2,5-dichlorobenzyl)-4-methyl-2-(5-propoxypyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(129) 1-(2,5-dichlorobenzyl)-2-(5-isobutoxypyridin-3-yl)-4-methyl-1H-imidazole-5-carboxylic acid;

(130) 2-(5-(cyclohexylmethoxy)pyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-methyl-1H-imidazole-5-carboxylic acid;

(131) 2-(5-(benzyloxy)pyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-methyl-1H-imidazole-5-carboxylic acid;

(132) 2-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-(hydroxymethyl)-1H-imidazole-5-carboxylic acid;

(133) 2-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-((dimethylamino)methyl)-1H-imidazole-5-carboxylic acid;

(134) 2-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-((diethylamino)methyl)-1H-imidazole-5-carboxylic acid;

(144) 2-(5-bromopyridin-3-yl)-1-(2,5-dichlorobenzyl)-1H-imidazole-5-carboxylic acid;

(145) 1-(2,5-dichlorobenzyl)-2-(5-methylpyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(146) 2-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-(difluoromethyl)-1H-imidazole-5-carboxylic acid;

(147) 1-(2,5-dichlorobenzyl)-2-(5-(difluoromethyl) pyridin-3-yl)-4-methyl-1H-imidazole-5-carboxylic acid;

(148) 2-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-ethynyl-1H-imidazole-5-carboxylic acid;

(149) 2-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-1H-imidazole-4,5-dicarboxylic acid;

(150) 2-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-(1-hydroxyethyl)-1H-imidazole-5-carboxylic acid;

(151) 1-(2,5-dichlorobenzyl)-2-(5-fluoropyridin-3-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazole-5-carboxylic acid;

(152) 2-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-(2-hydroxypropan-2-yl)-1H-imidazole-5-carboxylic acid;

(153) 1-(2,5-dichlorobenzyl)-4-(2-hydroxypropan-2-yl)-2-(5-methylpyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(154) 1-(2,5-dichlorobenzyl)-2-(5-fluoropyridin-3-yl)-4-(3-hydroxypentan-3-yl)-1H-imidazole-5-carboxylic acid;

(155) 2-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-4-(3-hydroxypentan-3-yl)-1H-imidazole-5-carboxylic acid;

(156) 1-(2,5-dichlorobenzyl)-4-(3-hydroxypentan-3-yl)-2-(5-methylpyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(157) 4-acetyl-2-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-1H-imidazole-5-carboxylic acid;

(158) 4-chloro-1-(2,5-dichlorobenzyl)-2-(5-methylpyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(159) 4-chloro-2-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-1H-imidazole-5-carboxylic acid;

(161) 2-(5-chloropyridin-3-yl)-1-(1-(2,5-dichlorophenyl)ethyl)-4-methyl-1H-imidazole-5-carboxylic acid;

(168) 1-(2-chloro-5-methylbenzyl)-4-methyl-2-(5-methylpyridin-3-yl)-1H-imidazole-5-carboxylic acid;

(169) 1-(2-chloro-5-methylbenzyl)-2-(5-chloropyridin-3-yl)-4-methyl-1H-imidazole-5-carboxylic acid;

(191) 2-((2-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-1H-imidazole-5-yl)thio)-2-methylpropanoic acid;

(192) 1-((2-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-1H-imidazol-5-yl)thio)cyclobutanecarboxylic acid; and

(193) 2-((5-(5-chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-1H-imidazol-2-yl)thio)-2-methylpropanoic acid.

10. A pharmaceutical composition comprising the pyridine derivative, or the pharmaceutically acceptable salt thereof, according to claim 1 .