Heterocyclic compounds as inhibitors of class I PI3KS
View Patent ↗The present application discloses a novel class of heterocycles as class I PI3Ks inhibitors. The compounds claimed herein could be used alone or in combination therapies for the treatment of a wide range of disorders such as autoimmune, inflammatory and allergic diseases, asthma, COPD, parasitic infections, diabetes, and cancer.
1. A compound having the structure of formula (I):
wherein:
X is selected from: —CH 2 CH 2 —, —CH═CHCH 2 — or —CH 2 CH 2 CH 2 —;
Z is hydrogen;
R 1 is selected from: phenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, piperidine, morpholine, or phenyl which is substituted by at least one substituent selected from: deuterium, —CH 3 , —OCH 3 , —OCF 3 , or —F;
R 2 and R 3 are independently selected from: hydrogen, deuterium, C 1 -C 6 alkyl, or halogen;
Y is selected from:
or a pharmaceutically acceptable salt thereof.
2. The compound or a pharmaceutically acceptable salt thereof according to claim 1 , wherein R 2 and R 3 are independently selected from: hydrogen, deuterium, —F, —Cl, or —CH 3 .
3. A compound having the structure of formula (II):
wherein:
X is —CH 2 CH 2 —;
Z is hydrogen;
R 1 is selected from: phenyl, pyridyl, or morpholine;
R 2 and R 3 are independently selected from: hydrogen, deuterium, —F, —Cl, or —CH 3 ;
Y is selected from:
or a pharmaceutically acceptable salt thereof.
4. The compound of claims 1 , 2 or 3 , or a pharmaceutically acceptable salt thereof, wherein the compound is selected from: