Use of nitrite salts in chronic ischemia
Methods of treating a subject who has chronic tissue ischemia are disclosed. The methods can include administering to the subject a pharmaceutical composition comprising inorganic nitrite or a pharmaceutically acceptable salt thereof, for a time and in an amount sufficient to result in blood vessel growth in the ischemic tissue. The subject can be diagnosed as having a medical condition that results in persistent or recurring restriction of blood supply to a tissue, for example, peripheral artery disease, diabetes, atherosclerotic cardiovascular disease or defective wound healing. The methods can include the step of identifying a suitable subject.
1. A method of treating peripheral neuropathy in a human subject, the method comprising: orally administering to the subject a pharmaceutical composition comprising about 40 mg of sodium nitrite one or two times per day for at least ten days, thereby treating the peripheral neuropathy.
2. The method of claim 1 , wherein the sodium nitrite is administered until a symptom of peripheral neuropathy in the subject improves.
3. The method of claim 1 , wherein the sodium nitrite is administered to a circulating nitrite concentration in the subject of about 0.01 μM to about 0.6 μM.
4. The method of claim 1 , wherein administration of said sodium nitrite alters nitrite levels in the blood.
5. The method of claim 1 , wherein administration of said sodium nitrite raises nitrite levels in the ischemic tissue.
6. The method of claim 1 , wherein the sodium nitrite is administered two times per day.
7. The method of claim 1 , wherein sodium nitrite is the only active ingredient administered to the subject.
8. A method of treating pain associated with peripheral vascular disease in a human subject, the method comprising: orally administering to the subject a pharmaceutical composition comprising about 40 mg of sodium nitrite one or two times per day for at least ten days, thereby treating the pain.