Pyridine CDK9 kinase inhibitors

1. A compound having Formula (Ia), or a pharmaceutically acceptable salt thereof,

wherein

R 12 is halo;

J is N or CH;

Q is N or CR 1 ;

Z is N or CR 1 ;

wherein the bond between X and Y may be a single or a double bond; and

if a double bond is present, then Y is CR 3 and X is CH, Y is CH and X is CH, Y is N and X is CH, Y is N and X is CR 3 , Y is CR 3 and X is N, Y is N and X is N, or Y is CH and X is N; and

if a single bond is present, then Y is CH 2 and X is CH 2 or C(O), or Y is NH or N(C 1 -C 3 alkyl) and X is C(O);

R 3 is selected from the group consisting of R 3A , C(O)R 3A , and CN;

R 3A is selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocycloalkyl, and heterocycloalkenyl; wherein the R 3A C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl are optionally substituted with one or more substituents independently selected from the group consisting of R 3B , OR 3B , and halo; wherein the R 3A aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocycloalkyl, and heterocycloalkenyl are optionally substituted with one or more halo;

R 3B is selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, and aryl, wherein the R 3B aryl is optionally substituted with one or more substituents independently selected from the group consisting of F, Cl, Br, and I;

R 1 is selected from the group consisting of H, CN, Cl, Br, I, F, R 1A ; and OR 1A ;

R 1A is selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl;

R 2 is selected from the group consisting of H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl; wherein the R 2 C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl are optionally substituted with one or more substituents independently selected from the group consisting of R 4 , OR 4 , SR 4 , S(O)R 4 , SO 2 R 4 , C(O)R 4 , CO(O)R 4 , OC(O)R 4 , OC(O)OR 4 , NH 2 , NHR 4 , N(R 4 ) 2 , NHC(O)R 4 , NR 4 C(O)R 4 , SO 2 NHC(O)R 4 , SO 2 NR 4 C(O)R 4 , NHS(O) 2 R 4 , NR 4 S(O) 2 R 4 , NHC(O)OR 4 , NR 4 C(O)OR 4 , SO 2 NHC(O)OR 4 , SO 2 NR 4 C(O)OR 4 , NHSO 2 NHC(O)OR 4 , NHSO 2 NR 4 C(O)OR 4 , NR 4 SO 2 NR 4 C(O)OR 4 , NR 4 SO 2 NHC(O)OR 4 , NHC(O)NH 2 , NHC(O)NHR 4 , NHC(O)N(R 4 ) 2 , NR 4 C(O)NHR 4 , NR 4 C(O)N(R 4 ) 2 , OC(O)NH 2 , OC(O)NHR 4 , OC(O)N(R 4 ) 2 , OC(O)NHSO 2 R 4 , OC(O)NR 4 SO 2 R 4 , C(O)NH 2 , C(O)NHR 4 , C(O)N(R 4 ) 2 , C(O)NHOH, C(O)NHOR 4 , C(O)NHSO 2 R 4 , C(O)NR 4 SO 2 R 4 , SO 2 NH 2 , SO 2 NHR 4 , SO 2 N(R 4 ) 2 , OSO 2 NH 2 , OSO 2 NHR 4 , OSO 2 N(R 4 ) 2 , C(O)NHCN, C(O)NR 4 CN, S(O)NR 4 , S(O)NSO 2 R 4 , C(O)H, C(O)OH, (O), OH, CN, NO 2 , F, Cl, Br and I;

R 4 , at each occurrence, is independently selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, heteroaryl, heterocycloalkyl, heterocycloalkenyl, cycloalkyl, and cycloalkenyl; wherein each R 4 C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl is optionally substituted with one or more substituents independently selected from the group consisting of R 5 , OR 5 , SR 5 , S(O)R 5 , SO 2 R 5 , C(O)R 5 , CO(O)R 5 , OC(O)R 5 , OC(O)OR 5 , NH 2 , NHR 5 , N(R 5 ) 2 , NHC(O)R 5 , NR 5 C(O)R 5 , NHS(O) 2 R 5 , NR 5 S(O) 2 R 5 , NHC(O)OR 5 , NR 5 C(O)OR 5 , NHC(O)NH 2 , NHC(O)NHR 5 , NHC(O)N(R 5 ) 2 , NR 5 C(O)NHR 5 , NR 5 C(O)N(R 5 ) 2 , C(O)NH 2 , C(O)NHR 5 , C(O)N(R 5 ) 2 , C(O)NHOH, C(O)NHOR 5 , C(O)NHSO 2 R 5 , C(O)NR 5 SO 2 R 5 , SO 2 NH 2 , SO 2 NHR 5 , SO 2 N(R 5 ) 2 , C(O)H, C(O)OH, OH, CN, NO 2 , F, Cl, Br and I; wherein each R 4 aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocycloalkyl, and heterocycloalkenyl is optionally substituted with one or more substituents independently selected from the group consisting of R 6 , OR 6 , SR 6 , S(O)R 6 , SO 2 R 6 , C(O)R 6 , CO(O)R 6 , OC(O)R 6 , OC(O)OR 6 , NH 2 , NHR 6 , N(R 6 ) 2 , NHC(O)R 6 , NR 6 C(O)R 6 , NHS(O) 2 R 6 , NR 6 S(O) 2 R 6 , NHC(O)OR 6 , NR 6 C(O)OR 6 , NHC(O)NH 2 , NHC(O)NHR 6 , NHC(O)N(R 6 ) 2 , NR 6 C(O)NHR 6 , NR 6 C(O)N(R 6 ) 2 , C(O)NH 2 , C(O)NHR 6 , C(O)N(R 6 ) 2 , C(O)NHOH, C(O)NHOR 6 , C(O)NHSO 2 R 6 , C(O)NR 6 SO 2 R 6 , SO 2 NH 2 , SO 2 NHR 6 , SO 2 N(R 6 ) 2 , C(O)H, C(O)OH, (O), OH, CN, NO 2 , F, Br and I;

R 5 , at each occurrence, is independently selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, heteroaryl, heterocycloalkyl, heterocycloalkenyl, cycloalkyl, and cycloalkenyl;

R 6 , at each occurrence, is independently selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, heteroaryl, heterocycloalkyl, heterocycloalkenyl, cycloalkyl, and cycloalkenyl; wherein each R 6 C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl is optionally substituted with one or more substituents independently selected from the group consisting of halo and R 6A ;

R 6A , at each occurrence, is independently selected from the group consisting of aryl, heteroaryl, heterocycloalkyl, heterocycloalkenyl, cycloalkyl, and cycloalkenyl; wherein each R 6A aryl, heteroaryl, heterocycloalkyl, heterocycloalkenyl, cycloalkyl, and cycloalkenyl is optionally substituted with C 1 -C 6 alkyl;

R 16 is selected from the group consisting of NH 2 , NHR 7 , NHC(O)R 7 , NHS(O) 2 R 7 , NHC(O)OR 7 , NHC(O)NH 2 , NHC(O)NHR 7 , and NHC(O)N(R 7 ) 2 ;

R 7 , at each occurrence, is independently selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, heteroaryl, heterocycloalkyl, heterocycloalkenyl, cycloalkyl, and cycloalkenyl; wherein each R 7 C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl is optionally substituted with one or more substituents independently selected from the group consisting of R 8 , SR 8 , S(O)R 8 , SO 2 R 8 , C(O)R 8 , CO(O)R 8 , OC(O)R 8 , OC(O)OR 8 , NH 2 , NHR 8 , N(R 8 ) 2 , NHC(O)R 8 , NR 8 C(O)R 8 , NHS(O) 2 R 8 , NR 8 S(O) 2 R 8 , NHSO 2 NH 2 , NR 8 SO 2 NH 2 , NHSO 2 NHR 8 , NR 8 SO 2 NHR 8 , NHSO 2 N(R 8 ) 2 , NR 8 SO 2 N(R 8 ) 2 , NHC(O)OR 8 , NR 8 C(O)OR 8 , NHC(O)NH 2 , NHC(O)NHR 8 , NHC(O)N(R 8 ) 2 , NR 8 C(O)NHR 8 , NR 8 C(O)N(R 8 ) 2 , C(O)NH 2 , C(O)NHR 8 , C(O)N(R 8 ) 2 , C(O)NHOH, C(O)NHOR 8 , C(O)NHSO 2 R 8 , C(O)NR 8 SO 2 R 8 , C(O)NHC(O)NH 2 , C(O)NR 8 C(O)NH 2 , C(O)NHC(O)NHR 8 , C(O)NR 8 C(O)NHR 8 , C(O)NHC(O)N(R 8 ) 2 , C(O)NR 8 C(O)N(R 8 ) 2 , SO 2 NH 2 , SO 2 NHR 8 , SO 2 N(R 8 ) 2 , C(O)H, C(O)OH, OH, CN, NO 2 , F, Cl, Br and I; wherein each R 7 aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocycloalkyl, and heterocycloalkenyl is optionally substituted with one or more substituents independently selected from the group consisting of R 9 , OR 9 , SR 9 , S(O)R 9 , SO 2 R 9 , C(O)R 9 , CO(O)R 9 , OC(O)R 9 , OC(O)OR 9 , NH 2 , NHR 9 , N(R 9 ) 2 , NHC(O)R 9 , NR 9 C(O)R 9 , NHS(O) 2 R 9 , NR 9 S(O) 2 R 9 , NHC(O)OR 9 , NR 9 C(O)OR 9 , NHC(O)NH 2 , NHC(O)NHR 9 , NHC(O)N(R 9 ) 2 , NR 9 C(O)NHR 9 , NR 9 C(O)N(R 9 ) 2 , C(O)NH 2 , C(O)NHR 9 , C(O)N(R 9 ) 2 , C(O)NHOH, C(O)NHOR 9 , C(O)NHSO 2 R 9 , C(O)NR 9 SO 2 R 9 , SO 2 NH 2 , SO 2 NHR 9 , SO 2 N(R 9 ) 2 , SO 2 NHC(O)OH, SO 2 NR 9 C(O)OH, SO 2 NHC(O)OR 9 , SO 2 NR 9 C(O)OR 9 , C(O)H, C(O)OH, (O), OH, CN, NO 2 , F, Cl, Br and I;

R 8 , at each occurrence, is independently selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, heteroaryl, heterocycloalkyl, heterocycloalkenyl, cycloalkyl, and cycloalkenyl; wherein each R 8 C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl is optionally substituted with one or more substituents independently selected from the group consisting of NHR 10 , and aryl; wherein each R 8 aryl, heteroaryl, heterocycloalkyl, heterocycloalkenyl, cycloalkyl, and cycloalkenyl is optionally substituted with one or more substituents independently selected from the group consisting of R 11 , OR 11 , halo, NH 2 , OH, and (O);

R 9 , at each occurrence, is independently selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, heteroaryl, heterocycloalkyl, heterocycloalkenyl, cycloalkyl, and cycloalkenyl; wherein each R 9 C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl is optionally substituted with one or more substituents independently selected from the group consisting of R 13 , OR 13 , SR 13 , S(O)R 13 , SO 2 R 13 , C(O)R 13 , CO(O)R 13 , OC(O)R 13 , OC(O)OR 13 , NH 2 , NHR 13 , N(R 13 ) 2 , NHC(O)R 13 , NR 13 C(O)R 13 , NHS(O) 2 R 13 , NR 13 S(O) 2 R 13 , NHC(O)OR 13 , NR 13 C(O)OR 13 , NHC(O)NH 2 , NHC(O)NHR 13 , NHC(O)N(R 13 ) 2 , NR 13 C(O)NHR 13 , NR 13 C(O)N(R 13 ) 2 , C(O)NH 2 , C(O)NHR 13 , C(O)N(R 13 ) 2 , C(O)NHOH, C(O)NHOR 13 , C(O)NHSO 2 R 13 , C(O)NR 13 SO 2 R 13 , SO 2 NH 2 , SO 2 NHR 13 , SO 2 N(R 13 ) 2 , C(O)H, C(O)OH, OH, CN, NO 2 , F, Cl, Br and I; wherein each R 9 aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocycloalkyl, and heterocycloalkenyl is optionally substituted with one or more substituents independently selected from the group consisting of R 14 , OR 14 , SR 14 , S(O)R 14 , SO 2 R 14 , C(O)R 14 , CO(O)R 14 , OC(O)R 14 , OC(O)OR 14 , NH 2 , NHR 14 , N(R 14 ) 2 , NHC(O)R 14 , NR 14 C(O)R 14 , NHS(O) 2 R 14 , NR 14 S(O) 2 R 14 , NHC(O)OR 14 , NR 14 C(O)OR 14 , NHC(O)NH 2 , NHC(O)NHR 14 , NHC(O)N(R 14 ) 2 , NR 14 C(O)NHR 14 , NR 14 C(O)N(R 14 ) 2 , C(O)NH 2 , C(O)NHR 14 , C(O)N(R 14 ) 2 , C(O)NHOH, C(O)NHOR 14 , C(O)NHSO 2 R 14 , C(O)NR 14 SO 2 R 14 , SO 2 NH 2 , SO 2 NHR 14 , SO 2 N(R 14 ) 2 , C(O)H, C(O)OH, (O), OH, CN, NO 2 , F, Cl, Br and I;

R 10 , at each occurrence, is independently selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, heteroaryl, heterocycloalkyl, heterocycloalkenyl, cycloalkyl, and cycloalkenyl;

R 11 , at each occurrence, is independently selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, heteroaryl, heterocycloalkyl, heterocycloalkenyl, cycloalkyl, and cycloalkenyl; wherein each R 11 C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl is optionally substituted with one or more substituents independently selected from the group consisting of NH 2 , C(O)NH 2 , SO 2 NH 2 , C(O)H, C(O)OH, OH, CN, NO 2 , F, Cl, Br and I; wherein each R 11 aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocycloalkyl, and heterocycloalkenyl is optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 6 alkyl, O—C 1 -C 6 alkyl, NH 2 , C(O)NH 2 , C(O)H, C(O)OH, OH, CN, NO 2 , F, Cl, Br and I;

R 13 , at each occurrence, is independently selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, heteroaryl, heterocycloalkyl, heterocycloalkenyl, cycloalkyl, and cycloalkenyl; wherein each R 13 C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl is optionally substituted with one or more substituents independently selected from the group consisting of aryl, NH 2 , C(O)NH 2 , SO 2 NH 2 , C(O)H, C(O)OH, OH, CN, NO 2 , F, Cl, Br and I; wherein each R 13 aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocycloalkyl, and heterocycloalkenyl is optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 6 alkyl, O—C 1 -C 6 alkyl, C 1 -C 6 alkyl-O—C 1 -C 6 alkyl, NH 2 , C(O)NH 2 , C(O)H, C(O)OH, OH, CN, NO 2 , F, Cl, Br and I; and

R 14 , at each occurrence, is independently selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, heteroaryl, heterocycloalkyl, heterocycloalkenyl, cycloalkyl, and cycloalkenyl; wherein each R 14 C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl is optionally substituted with one or more substituents independently selected from the group consisting of aryl, NH 2 , C(O)NH 2 , SO 2 NH 2 , C(O)H, C(O)OH, OH, CN, NO 2 , F, Cl, Br and I; wherein each R 14 aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocycloalkyl, and heterocycloalkenyl is optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 6 alkyl, O—C 1 -C 6 alkyl, C 1 -C 6 alkyl-O—C 1 -C 6 alkyl, NH 2 , C(O)NH 2 , C(O)H, C(O)OH, OH, NO 2 , F, Cl, Br and I.

2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 12 is Cl.

3. The compound of claim 2 , or a pharmaceutically acceptable salt thereof, wherein R 16 is selected from the group consisting of NHR 7 and NHC(O)R 7 .

4. The compound of claim 3 , or a pharmaceutically acceptable salt thereof, wherein J is CH; Q is CR 1 ; Z is CR 1 ; wherein the bond between X and Y is a single bond; Y is CH 2 and X is CH 2 ; and R 1 is H.

5. The compound of claim 3 , or a pharmaceutically acceptable salt thereof, wherein J is CH; Q is CR 1 ; Z is CR 1 ; wherein the bond between X and Y is a double bond; Y is N and X is CH; and R 1 is H.

6. The compound of claim 4 , or a pharmaceutically acceptable salt thereof, wherein R 2 is C 1 -C 6 alkyl; wherein the R 2 C 1 -C 6 alkyl is optionally substituted with one or more substituents independently selected from the group consisting of R 4 , SO 2 R 4 , C(O)R 4 , N(R 4 ) 2 , C(O)N(R 4 ) 2 , SO 2 NH 2 , and OH.

7. The compound of claim 5 , or a pharmaceutically acceptable salt thereof, wherein R 2 is C 1 -C 6 alkyl; wherein the R 2 C 1 -C 6 alkyl is optionally substituted with one or more substituents independently selected from the group consisting of R 4 , SO 2 R 4 , C(O)R 4 , N(R 4 ) 2 , C(O)N(R 4 ) 2 , SO 2 NH 2 , and OH.

8. The compound of claim 6 , or a pharmaceutically acceptable salt thereof, wherein R 4 , at each occurrence, is independently selected from the group consisting of C 1 -C 6 alkyl, aryl, heteroaryl, heterocycloalkyl, and cycloalkyl; wherein each R 4 C 1 -C 6 alkyl is optionally substituted with one or more OH; wherein each R 4 aryl, cycloalkyl, heteroaryl, and heterocycloalkyl is optionally substituted with one or more substituents independently selected from the group consisting of R 6 , SO 2 R 6 , CO(O)R 6 , NHS(O) 2 R 6 , SO 2 NH 2 , C(O)OH, OH, CN, and F.

9. The compound of claim 7 , or a pharmaceutically acceptable salt thereof, wherein R 4 , at each occurrence, is independently selected from the group consisting of C 1 -C 6 alkyl, aryl, heteroaryl, heterocycloalkyl, and cycloalkyl; wherein each R 4 C 1 -C 6 alkyl is optionally substituted with one or more OH; wherein each R 4 aryl, cycloalkyl, heteroaryl, and heterocycloalkyl is optionally substituted with one or more substituents independently selected from the group consisting of R 6 , SO 2 R 6 , CO(O)R 6 , NHS(O) 2 R 6 , SO 2 NH 2 , C(O)OH, OH, CN, and F.

10. The compound of claim 6 , or a pharmaceutically acceptable salt thereof, wherein R 4 , at each occurrence, is independently C 1 -C 6 alkyl; wherein each R 4 C 1 -C 6 alkyl is optionally substituted with one or more OH.

11. The compound of claim 7 , or a pharmaceutically acceptable salt thereof, wherein R 4 , at each occurrence, is independently C 1 -C 6 alkyl; wherein each R 4 C 1 -C 6 alkyl is optionally substituted with one or more OH.

12. The compound of claim 6 , or a pharmaceutically acceptable salt thereof, wherein R 4 , at each occurrence, is independently selected from the group consisting of aryl, heteroaryl, heterocycloalkyl, and cycloalkyl; wherein each R 4 aryl, cycloalkyl, heteroaryl, and heterocycloalkyl is optionally substituted with one or more substituents independently selected from the group consisting of R 6 , SO 2 R 6 , CO(O)R 6 , NHS(O) 2 R 6 , SO 2 NH 2 , C(O)OH, OH, CN, and F.

13. The compound of claim 7 , or a pharmaceutically acceptable salt thereof, wherein R 4 , at each occurrence, is independently selected from the group consisting of aryl, heteroaryl, heterocycloalkyl, and cycloalkyl; wherein each R 4 aryl, cycloalkyl, heteroaryl, and heterocycloalkyl is optionally substituted with one or more substituents independently selected from the group consisting of R 6 , SO 2 R 6 , CO(O)R 6 , NHS(O) 2 R 6 , SO 2 NH 2 , C(O)OH, OH, CN, and F.

14. A compound selected from the group consisting of:

(3R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-2,3-dihydro-1H-indol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-[5-chloro-4-(2,3-dihydro-1H-indol-6-yl)pyridin-2-yl]piperidine-3-carboxamide;

(3R)—N-[5-chloro-4-(1-methyl-1H-benzimidazol-6-yl)pyridin-2-yl]piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-2,3-dihydro-1H-indol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-5-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-indol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}cyclohexane-1,4-diamine;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-2,3-dihydro-1H-indol-6-yl]pyridin-2-yl}cyclohexane-1,4-diamine;

trans-4-({5-chloro-4-[1-(3-fluorobenzyl)-2,3-dihydro-1H-indol-6-yl]pyridin-2-yl}amino)cyclohexanol;

trans-4-({5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}amino)cyclohexanol;

trans-N-[5-chloro-4-(1-methyl-1H-benzimidazol-6-yl)pyridin-2-yl]cyclohexane-1,4-diamine;

(3R)—N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[2-(morpholin-4-yl)ethyl]-1H-benzimidazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(3-hydroxy-3-methylbutyl)-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(4-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(3,4-difluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[2-(3-fluorophenyl)ethyl]-1H-benzimidazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(2-sulfamoylethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[(1,1-dioxidotetrahydrothiophen-3-yl)methyl]-1H-benzimidazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(2-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(pyridin-3-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methyl]-1H-benzimidazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[(5-methyl-4H-1,2,4-triazol-3-yl)methyl]-1H-benzimidazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(1,3-thiazol-4-ylmethyl)-1H-benzimidazol-5-yl]pyridin-2-yl}piperidine-3-carboxamide-(3R)—N-{5-chloro-4-[1-(1,3-thiazol-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide (1:1);

5-chloro-N-cyclopentyl-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-amine;

1-[trans-4-({5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}amino)cyclohexyl]-3-methylurea;

N-[trans-4-({5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}amino)cyclohexyl]methanesulfonamide;

(3R)—N-[4-(1-benzyl-3-cyano-1H-indol-6-yl)-5-chloropyridin-2-yl]piperidine-3-carboxamide;

N′-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N-methyl-N-(pyridin-2-yl)propane-1,3-diamine;

1-({5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}amino)-3-(dimethylamino)propan-2-ol;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-[(5-methyl-4H-1,2,4-triazol-3-yl)methyl]pyridin-2-amine;

(3R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-pyrrolo[3,2-b]pyridin-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-(pyridin-3-yl)ethane-1,2-diamine;

N-[(5-amino-4H-1,2,4-triazol-3-yl)methyl]-5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-amine;

N-benzyl-N′-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N-methylpropane-1,3-diamine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-(pyrimidin-2-ylmethyl)pyridin-2-amine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-[1-(pyridin-4-yl)propan-2-yl]pyridin-2-amine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-[1-(1-methyl-1H-pyrazol-4-yl)piperidin-3-yl]pyridin-2-amine;

5-[({5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}amino)methyl]pyrimidin-2-amine;

5-chloro-N-[2-(1-ethylpiperidin-4-yl)ethyl]-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-amine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)ethyl]pyridin-2-amine;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-(pyridin-4-yl)ethane-1,2-diamine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-[2-(1-methylpiperidin-4-yl)ethyl]pyridin-2-amine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-[2-(pyridin-4-yl)propyl]pyridin-2-amine;

N 1 -{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N 2 ,N 2 ,2-trimethylpropane-1,2-diamine;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-phenylpropane-1,3-diamine;

N 3 -{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}butane-1,3-diamine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-amine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-(1H-imidazol-4-ylmethyl)pyridin-2-amine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-(pyrazin-2-ylmethyl)pyridin-2-amine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-[1-(pyrazin-2-yl)propan-2-yl]pyridin-2-amine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-(1-methylpyrrolidin-3-yl)pyridin-2-amine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-[2-(pyridin-3-yl)ethyl]pyridin-2-amine;

N′-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N,N-dimethylbutane-1,4-diamine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-[(1-methylpiperidin-4-yl)methyl]pyridin-2-amine;

N-benzyl-N′-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N-methylethane-1,2-diamine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-[2-(pyridin-2-yl)ethyl]pyridin-2-amine;

4-({5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}amino)-2-methylbutan-2-ol;

N′-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N-methyl-N-phenylpropane-1,3-diamine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-(1-methylpiperidin-4-yl)pyridin-2-amine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-[2-(pyridin-4-yl)ethyl]pyridin-2-amine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-(pyrimidin-5-ylmethyl)pyridin-2-amine;

N 2 -{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2-methylpropane-1,2-diamine;

5-chloro-N-(2-cyclohexylethyl)-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-amine;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N-phenylethane-1,2-diamine;

N′-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N,N,2,2-tetramethylpropane-1,3-diamine;

2-({5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}amino)ethanol;

N-benzyl-5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-amine;

N′-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N,N-dimethylpropane-1,3-diamine;

3-({5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}amino)propan-1-ol;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}propane-1,3-diamine;

4-[({5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}amino)methyl]phenol;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}butane-1,4-diamine;

N-[2-(4-aminophenyl)ethyl]-5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-amine;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2,2-dimethylpropane-1,3-diamine;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}ethane-1,2-diamine;

N-[4-(aminomethyl)benzyl]-5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-amine;

1-({5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}amino)-2-methylpropan-2-ol;

1-amino-3-({5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}amino)propan-2-ol;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-(pyridin-2-yl)ethane-1,2-diamine;

(3R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-1-azabicyclo[2.2.2]octan-3-amine;

(3S)—N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-1-azabicyclo[2.2.2]octan-3-amine;

2-benzyl-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}octahydro-1H-isoindol-4-amine;

2-benzyl-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}octahydrocyclopenta[c]pyrrol-4-amine;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-9-(cyclopropylmethyl)-9-azabicyclo[3.3.1]nonan-3-amine;

benzyl 4-({5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}amino)-4-(4-fluorophenyl)piperidine-1-carboxylate;

tert-butyl {5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}carbamate;

(3R)—N-(5-chloro-4-{1-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]-1H-benzimidazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[2-(pyridin-3-yl)ethyl]-1H-benzimidazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-methylpropane-1,3-diamine;

N-[(trans-4-aminocyclohexyl)methyl]-5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-amine;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-methylbutane-1,4-diamine;

N-benzyl-N′-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}ethane-1,2-diamine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-[2-(piperidin-4-yl)ethyl]pyridin-2-amine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-[2-(piperidin-3-yl)ethyl]pyridin-2-amine;

N 2 -{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-1-phenylethane-1,2-diamine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-(piperidin-3-yl)pyridin-2-amine;

N-[(2R)-azetidin-2-ylmethyl]-5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-amine;

N-[2-(azetidin-2-yl)ethyl]-5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-amine;

(4aS,8R,8aS)—N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}decahydroisoquinolin-8-amine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-[2-(pyrrolidin-2-yl)ethyl]pyridin-2-amine;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-6-azaspiro[3.5]nonan-2-amine;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-7-azaspiro[3.5]nonan-2-amine;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-7-azaspiro[3.5]nonan-1-amine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-{[(2R,4S)-4-fluoropyrrolidin-2-yl]methyl}pyridin-2-amine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-[(4-fluoropyrrolidin-3-yl)methyl]pyridin-2-amine;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-6-azaspiro[3.4]octan-2-amine;

(3R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzotriazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[2-(methylsulfonyl)ethyl]-1H-benzimidazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[2-(methylsulfonyl)ethyl]-1H-benzotriazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(4-fluorobenzyl)-1H-benzotriazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(3,4-difluorobenzyl)-1H-benzotriazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[2-(3-fluorophenyl)ethyl]-1H-benzotriazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(2-sulfamoylethyl)-1H-benzotriazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-{2-[4-(4-methylphenyl)piperidin-4-yl]ethyl}pyridin-2-amine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-{2-[4-(4-methoxyphenyl)piperidin-4-yl]ethyl}pyridin-2-amine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-[(4-fluoropiperidin-4-yl)methyl]pyridin-2-amine;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-{2-[3-(4-methoxyphenyl)pyrrolidin-3-yl]ethyl}pyridin-2-amine;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-6-azaspiro[3.4]octan-1-amine;

(1S,4R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-6-azaspiro[3.5]nonan-1-amine;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-5-thia-2-azaspiro[3.4]octan-8-amine 5,5-dioxide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-9-azabicyclo[3.3.1]nonan-3-amine;

(3S)—N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}azepan-3-amine;

(3R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}azepan-3-amine;

(1R,4R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-6-azaspiro[3.5]nonan-1-amine;

N-{[3-(aminomethyl)cyclohexyl]methyl}-5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-amine;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2-(piperidin-4-yl)acetamide;

4-({5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}amino)benzenesulfonamide;

(3R)—N-(5-chloro-4-{1-[(5-fluoropyridin-3-yl)methyl]-1H-benzimidazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[(4-cyanotetrahydro-2H-pyran-4-yl)methyl]-1H-benzimidazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-pyrrolo[2,3-b]pyridin-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[5-fluoro-1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-indazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-[4-(1-{2-[bis(2-hydroxyethyl)amino]ethyl}-1H-benzotriazol-6-yl)-5-chloropyridin-2-yl]piperidine-3-carboxamide;

(3R)—N-[5-chloro-4-(2-oxo-2,3-dihydro-1H-indol-6-yl)pyridin-2-yl]piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[3-(dimethylamino)propyl]-1H-benzimidazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[3-(dimethylamino)propyl]-1H-benzotriazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[2-(morpholin-4-yl)ethyl]-1H-benzotriazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-2-methyl-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[3-(tetrahydro-2H-pyran-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[(1R)-1-(3-fluorophenyl)ethyl]-1H-benzimidazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[(1R)-1-(3-fluorophenyl)ethyl]-1H-benzotriazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[3-(3-fluorobenzyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[5-chloro-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

N-(5-chloro-4-{1-[(5-methylpyrazin-2-yl)methyl]-2,3-dihydro-1H-indol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

N-[5-chloro-4-(1-{4-[(methylsulfonyl)amino]benzyl}-2,3-dihydro-1H-indol-6-yl)pyridin-2-yl]piperidine-3-carboxamide;

N-(5-chloro-4-{1-[4-fluoro-3-(methylsulfonyl)benzyl]-2,3-dihydro-1H-indol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

N-(5-chloro-4-{1-[(2-methylpyrimidin-5-yl)methyl]-2,3-dihydro-1H-indol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

N-(5-chloro-4-{1-[3-(methylsulfonyl)benzyl]-2,3-dihydro-1H-indol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

N-(5-chloro-4-{1-[(6-methylpyridin-3-yl)methyl]-2,3-dihydro-1H-indol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

N-{5-chloro-4-[1-(pyrrolidin-3-ylmethyl)-2,3-dihydro-1H-indol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

4-[(6-{5-chloro-2-[(piperidin-3-ylcarbonyl)amino]pyridin-4-yl}-2,3-dihydro-1H-indol-1-yl)methyl]benzoic acid;

N-(5-chloro-4-{1-[4-(methylsulfonyl)benzyl]-2,3-dihydro-1H-indol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

methyl 4-[(6-{5-chloro-2-[(piperidin-3-ylcarbonyl)amino]pyridin-4-yl}-2,3-dihydro-1H-indol-1-yl)methyl]benzoate;

N-{5-chloro-4-[1-(pyrimidin-5-ylmethyl)-2,3-dihydro-1H-indol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

N-[5-chloro-4-(1-{[6-(trifluoromethyl)pyridin-2-yl]methyl}-2,3-dihydro-1H-indol-6-yl)pyridin-2-yl]piperidine-3-carboxamide;

N-{5-chloro-4-[1-(quinolin-6-ylmethyl)-2,3-dihydro-1H-indol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

N-{4-[1-(1H-benzimidazol-2-ylmethyl)-2,3-dihydro-1H-indol-6-yl]-5-chloropyridin-2-yl}piperidine-3-carboxamide;

N-{5-chloro-4-[1-(2,3-dihydro-1,4-benzodioxin-5-ylmethyl)-2,3-dihydro-1H-indol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

N-(5-chloro-4-{1-[(1-methyl-1H-benzimidazol-2-yl)methyl]-2,3-dihydro-1H-indol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

N-(5-chloro-4-{1-[(1-methyl-1H-benzotriazol-5-yl)methyl]-2,3-dihydro-1H-indol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

N-{4-[1-(1,3-benzodioxol-4-ylmethyl)-2,3-dihydro-1H-indol-6-yl]-5-chloropyridin-2-yl}piperidine-3-carboxamide;

N-{5-chloro-4-[1-(4-methylbenzyl)-2,3-dihydro-1H-indol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

N-{5-chloro-4-[1-(quinoxalin-6-ylmethyl)-2,3-dihydro-1H-indol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

N-{5-chloro-4-[1-(pyrazin-2-ylmethyl)-2,3-dihydro-1H-indol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

N-{5-chloro-4-[1-(2,3-dihydro[1,4]dioxino[2,3-b]pyridin-7-ylmethyl)-2,3-dihydro-1H-indol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

N-[5-chloro-4-(1-{[6-(methylsulfonyl)pyridin-3-yl]methyl}-2,3-dihydro-1H-indol-6-yl)pyridin-2-yl]piperidine-3-carboxamide;

N-{5-chloro-4-[1-(4-sulfamoylbenzyl)-2,3-dihydro-1H-indol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

N-(5-chloro-4-{1-[3-fluoro-4-(methylsulfonyl)benzyl]-2,3-dihydro-1H-indol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

N-(5-chloro-4-{1-[4-(2H-tetrazol-5-yl)benzyl]-2,3-dihydro-1H-indol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

N-{5-chloro-4-[1-(pyrrolidin-2-ylmethyl)-2,3-dihydro-1H-indol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

N-(5-chloro-4-{1-[(1-methylpiperidin-4-yl)methyl]-2,3-dihydro-1H-indol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-imidazo[4, 5-b]pyridin-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-[5-chloro-4-(1-{[3-(morpholin-4-yl)oxetan-3-yl]methyl}-1H-benzimidazol-6-yl)pyridin-2-yl]piperidine-3-carboxamide;

(3R)—N-[5-chloro-4-(1-{[3-(pyrrolidin-1-yl)oxetan-3-yl]methyl}-1H-benzimidazol-6-yl)pyridin-2-yl]piperidine-3-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-7-azaspiro[3.5]nonan-2-amine;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-7-(methylsulfonyl)-7-azaspiro[3.5]nonan-2-amine;

(2E)-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-3-(pyridin-4-yl)prop-2-enamide;

(1R,2S)—N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-cyclopentylcyclobutane-1,2-dicarboxamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2-(2-oxopyridin-1(2H)-yl)propanamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2-(methylsulfonyl)acetamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-1-(3-chlorophenyl)-5-oxopyrrolidine-3-carboxamide;

1-benzyl-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-5-oxopyrrolidine-3-carboxamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2,3-dihydro[1,4]dioxino[2,3-b]pyridine-7-carboxamide;

(3R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-3-(pyridin-3-yl)-1H-pyrrolo[1,2-c][1,3]thiazole-7-carboxamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-3-oxocyclobutanecarboxamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-6-oxospiro[3.3]heptane-2-carboxamide;

benzyl (1R,5S,6r)-6-({5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}carbamoyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-1-methylazetidine-3-carboxamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-3-methyloxetane-3-carboxamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-4-hydroxy-4-(trifluoromethyl)cyclohexanecarboxamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-1-(2,2-dimethylpropanoyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-6-carboxamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2-(methylsulfonyl)-5-thia-2-azaspiro[3.4]octane-8-carboxamide 5,5-dioxide;

N 8 -{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N 2 -ethyl-5-thia-2-azaspiro[3.4]octane-2,8-dicarboxamide 5,5-dioxide;

N 8 -{-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N 2 -phenyl-5-thia-2-azaspiro[3.4]octane-2,8-dicarboxamide 5,5-dioxide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-7-(cyclohexylcarbonyl)-1-thia-7-azaspiro[4.4]nonane-4-carboxamide 1,1-dioxide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-7-(2-methylpropanoyl)-1-thia-7-azaspiro[4.4]nonane-4-carboxamide 1,1-dioxide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-7-(phenylsulfonyl)-1-thia-7-azaspiro[4.4]nonane-4-carboxamide 1,1-dioxide;

7-benzoyl-N-{-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-1-thia-7-azaspiro[4.4]nonane-4-carboxamide 1,1-dioxide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-7-ethyl-1-thia-7-azaspiro[4.4]nonane-4-carboxamide 1,1-dioxide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2-oxohexahydro-2H-cyclopenta[d][1,3]oxazole-5-carboxamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-7-(methylsulfonyl)-1-thia-7-azaspiro[4.4]nonane-4-carboxamide 1,1-dioxide;

(2E)-N-carbamoyl-N′-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}but-2-enediamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}cyclopropane-1,1-dicarboxamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-1H-pyrazole-4-carboxamide;

trans-N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}cyclohexane-1,4-diamine;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-4-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2-oxohexahydro-2H-cyclopenta[d][1,3]oxazole-5-carboxamide;

(2s,4r)-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-6-azaspiro[3.4]octan-2-amine;

(2r,4s)-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-6-azaspiro[3.4]octan-2-amine;

(2s,4r)-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-6-azaspiro[3.5]nonan-2-amine;

(2r,4s)-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-6-azaspiro[3.5]nonan-2-amine;

(3 S)—N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-imidazo[4, 5-b]pyrazin-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

N-(5-chloro-4-{1-[2-(dimethylamino)-2-oxoethyl]-2,3-dihydro-1H-indol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

N-(5-chloro-4-{1-[2-(morpholin-4-yl)-2-oxoethyl]-2,3-dihydro-1H-indol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

N-(5-chloro-4-{1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-2,3-dihydro-1H-indol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[3-cyano-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-pyrrolo[3,2-b]pyridin-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

4-[(6-{5-chloro-2-[(2-hydroxyethyl)amino]pyridin-4-yl}-1H-benzimidazol-1-yl)methyl]tetrahydro-2H-pyran-4-carbonitrile;

2-[(5-chloro-4-{1-[(5-fluoropyridin-3-yl)methyl]-1H-benzimidazol-6-yl}pyridin-2-yl)amino]ethanol;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-(pyridin-2-ylmethyl)cyclohexane-1,4-diamine;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-(pyridin-3-ylmethyl)cyclohexane-1,4-diamine;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-(pyridin-4-ylmethyl)cyclohexane-1,4-diamine;

trans-N-(1,3-benzodioxol-5-ylmethyl)-N′-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}cyclohexane-1,4-diamine;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-(1,3-thiazol-2-ylmethyl)cyclohexane-1,4-diamine;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-{[1-(methoxymethyl)-2,3-dihydro-1H-1,2,3-triazol-4-yl]methyl}cyclohexane-1,4-diamine;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-[2-(morpholin-4-yl)ethyl]cyclohexane-1,4-diamine;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-[2-methyl-2-(morpholin-4-yl)propyl]cyclohexane-1,4-diamine;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-(tetrahydrofuran-2-ylmethyl)cyclohexane-1,4-diamine;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-[(2,5-dimethoxytetrahydrofuran-3-yl)methyl]cyclohexane-1,4-diamine;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-(cyclopropylmethyl)cyclohexane-1,4-diamine;

3-{[trans-4-({5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}amino)cyclohexyl]amino}propane-1,2-diol;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-(1-methoxypropan-2-yl)cyclohexane-1,4-diamine;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-(1,3-dimethoxypropan-2-yl)cyclohexane-1,4-diamine;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-(2-phenoxyethyl)cyclohexane-1,4-diamine;

trans-N-[3-(benzyloxy)propyl]-N′-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}cyclohexane-1,4-diamine;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-[2,2-dimethyl-3-(phenylsulfinyl)propyl]cyclohexane-1,4-diamine;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N-(2-methoxypropyl)cyclohexane-1,4-diamine;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-[2-(cyclohexyloxy)propyl]cyclohexane-1,4-diamine;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N-[(5,5-dimethyltetrahydrofuran-2-yl)methyl]cyclohexane-1,4-diamine;

trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N-(3-methoxypropyl)cyclohexane-1,4-diamine;

2-{[trans-4-({5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}amino)cyclohexyl]amino}propan-1-ol;

(3R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzotriazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-pyrrolo[3,2-b]pyridin-6-yl]pyridin-2-yl}-6-azaspiro[3.4]octan-2-amine;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}cyclohexane-1,3-diamine;

(3R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-2-(trifluoromethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[2-(trifluoromethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-3-(methoxymethyl)-1H-pyrrolo[3,2-b]pyridin-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[3-(methoxymethyl)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-pyrrolo[3,2-b]pyridin-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}pyridine-4-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}pyridine-3-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-1-methyl-1H-imidazole-4-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-1H-imidazole-4-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-1,3-thiazole-4-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-1H-1,2,4-triazole-3-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}pyrimidine-5-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}pyrazine-2-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-1H-pyrazole-3-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-1H-1,2,3-triazole-4-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}azetidine-3-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-1H-pyrazole-4-carboxamide;

(3aR,6aS)—N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}octahydrocyclopenta[c]pyrrole-5-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2-azaspiro[3.3]heptane-6-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-3-azabicyclo[3.1.0]hexane-6-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-3-oxocyclobutanecarboxamide;

(3R)—N-{5-chloro-4-[2-(3-fluorophenyl)-1-methyl-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[2-(3-fluorobenzyl)-1-methyl-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-1,2,5,6-tetrahydropyridine-3-carboxamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2-(tetrahydro-2H-pyran-4-ylsulfonyl)propanamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-6-carboxamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-6-carboxamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-3,4-dihydro-2H-pyrano[2,3-b]pyridine-6-carboxamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2-sulfamoylacetamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2-[(4-methylpiperazin-1-yl)sulfonyl]acetamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-5-oxo-D-prolinamide;

N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N 2 -(dimethylsulfamoyl)glycinamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2-(tetrahydro-2H-pyran-4-ylsulfonyl)propanamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-6-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-6-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-3,4-dihydro-2H-pyrano[2,3-b]pyridine-6-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2-sulfamoylacetamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N 2 -(ethylsulfonyl)glycinamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-5-oxo-D-prolinamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N 2 -(dimethylsulfamoyl)glycinamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2-[(4-methylpiperazin-1-yl)sulfonyl]acetamide;

(3R)—N-(5-chloro-4-{1-[4-(methylsulfonyl)benzyl]-1H-benzotriazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

cis-3-amino-N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}cyclobutanecarboxamide;

trans-3-amino-N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}cyclobutanecarboxamide;

(1R,5S,6r)-N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-3-azabicyclo[3.1.0]hexane-6-carboxamide;

(2R)—N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}azetidine-2-carboxamide;

6-amino-N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}spiro[3.3]heptane-2-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2-(furan-2-yl)-2-(piperazin-1-yl)acetamide;

1-amino-N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}cyclopentanecarboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-5-thia-2-azaspiro[3.4]octane-8-carboxamide 5,5-dioxide;

(2S,3R)—N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-3-ethylazetidine-2-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-4-(4-fluorophenyl)piperidine-4-carboxamide;

N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-1-thia-7-azaspiro[4.4]nonane-4-carboxamide 1,1-dioxide;

(3R)—N-(5-chloro-4-{1-[2-(3-fluorophenyl)-2-oxoethyl]-1H-pyrrolo[3,2-b]pyridin-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

N-(5-chloro-4-{1-[(5-fluoropyridin-3-yl)methyl]-1H-pyrrolo[3,2-b]pyridin-6-yl}pyridin-2-yl)-3-oxocyclobutanecarboxamide;

(3R)—N-(5-chloro-4-{1-[(1-methyl-1H-benzotriazol-6-yl)methyl]-1H-pyrrolo[3,2-b]pyridin-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[2-oxo-2-(tetrahydro-2H-pyran-4-yl)ethyl]-1H-pyrrolo[3,2-b]pyridin-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[2-hydroxy-2-(tetrahydro-2H-pyran-4-yl)ethyl]-1H-pyrrolo[3,2-b]pyridin-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[(trans-4-hydroxy-4-methylcyclohexyl)methyl]-1H-benzotriazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{5-fluoro-1-[(1R)-1-(3-fluorophenyl)ethyl]-1H-benzotriazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

methyl 4-{[6-(5-chloro-2-{[(3R)-piperidin-3-ylcarbonyl]amino}pyridin-4-yl)-1H-benzimidazol-1-yl]methyl}benzoate;

methyl 4-{[6-(5-chloro-2-{[(3R)-piperidin-3-ylcarbonyl]amino}pyridin-4-yl)-1H-benzotriazol-1-yl]methyl}benzoate;

(3R)—N-(5-chloro-4-{1-[3-(3-fluorophenyl)propyl]-1H-benzimidazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[3-(3-fluorophenyl)propyl]-1H-benzotriazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

4-{[6-(5-chloro-2-{[(3R)-piperidin-3-ylcarbonyl]amino}pyridin-4-yl)-1H-benzotriazol-1-yl]methyl}benzoic acid;

4-{[6-(2-amino-5-chloropyridin-4-yl)-1H-benzotriazol-1-yl]methyl}benzoic acid;

(3R)—N-{4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[(5-fluoropyridin-3-yl)methyl]-1H-pyrrolo[3,2-b]pyridin-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[1-(pyridin-3-yl)ethyl]-1H-benzotriazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-5-methoxy-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

4-{[6-(5-chloro-2-{[(3R)-piperidin-3-ylcarbonyl]amino}pyridin-4-yl)-1H-benzimidazol-1-yl]methyl}benzoic acid;

(3R)—N-{5-chloro-4-[1-(3-fluorobenzyl)-5-methoxy-1H-benzotriazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(1R,4R,6R)—N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2-azabicyclo[2.2.1]heptane-6-carboxamide;

(1R,4R,6S)—N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2-azabicyclo[2.2.1]heptane-6-carboxamide;

(3R)—N-{5-chloro-4-[1-(thiophen-2-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-{5-chloro-4-[1-(thiophen-2-ylmethyl)-1H-benzotriazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

(3R)—N-(5-chloro-4-{1-[2-(dimethylamino)-2-(3-fluorophenyl)ethyl]-1H-benzotriazol-6-yl}pyridin-2-yl)piperidine-3-carboxamide;

(3R)—N-[5-chloro-4-(1-{3-[(4-methylpiperazin-1-yl)methyl]benzyl}-1H-benzotriazol-6-yl)pyridin-2-yl]piperidine-3-carboxamide;

5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]-N-{3-[(methylsulfonyl)methyl]phenyl}pyridin-2-amine;

(3R)—N-{5-chloro-4-[4-fluoro-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide;

ethyl {[(3R)-3-({5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}carbamoyl)piperidin-1-yl]sulfonyl}carbamate;

methyl (cis)-3-({5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}carbamoyl)cyclohexanecarboxylate;

(cis)-3-({5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}carbamoyl)cyclohexanecarboxylic acid;

(cis)-N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-3-[(3-hydroxyazetidin-1-yl)carbonyl]cyclohexanecarboxamide;

(cis)-N′-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N-(2-hydroxyethyl)-N-methylcyclohexane-1,3-dicarboxamide;

(cis)-N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-3-{[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]carbonyl}cyclohexanecarboxamide;

(3R)—N-[4-(1-methyl-1H-benzimidazol-6-yl)pyridin-2-yl]piperidine-3-carboxamide;

tert-butyl (3aR,6aS)-5-({5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}carbamoyl)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate;

(3aR,6aS)—N 5 -{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N 2 -methylhexahydrocyclopenta[c]pyrrole-2,5(1H)-dicarboxamide;

cis-4-({5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}amino)cyclohexanecarboxylic acid; and pharmaceutically acceptable salts thereof.

15. A pharmaceutical composition comprising an excipient and a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof.

16. A method of treating CDK9-mediated cancer in a patient, said method comprising administering to the patient a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof.

17. The method of claim 16 , wherein said cancer is selected from the group consisting of acoustic neuroma, acute leukemia, acute lymphoblastic leukemia, acute myelogenous leukemia, acute t-cell leukemia, basal cell carcinoma, bile duct carcinoma, bladder cancer, brain cancer, breast cancer, bronchogenic carcinoma, Burkitt's lymphoma, cervical cancer, chondrosarcoma, chordoma, choriocarcinoma, chronic leukemia, chronic lymphocytic leukemia, chronic myelocytic leukemia, chronic myelogenous leukemia, colon cancer, colorectal cancer, craniopharyngioma, cystadenocarcinoma, dysplasias, metaplasias, embryonal carcinoma, endometrial cancer, endotheliosarcoma, ependymoma, epithelial carcinoma, erythroleukemia, esophageal cancer, estrogen-receptor positive breast cancer, essential thrombocythemia, Ewing's tumor, fibrosarcoma, gastric carcinoma, germ cell testicular cancer, gestational trophobalstic disease, glioblastoma, head and neck cancer, heavy chain disease, hemangioblastoma, hepatoma, hepatocellular cancer, hormone insensitive prostate cancer, leiomyosarcoma, liposarcoma, lung cancer, lymphangioendothelio-sarcoma, lymphangiosarcoma, lymphoblastic leukemia, lymphoma, malignancies and hyperproliferative disorders of the bladder, breast, colon, lung, ovaries, pancreas, prostate, skin and uterus, lymphoid malignancies of T cell or B cell origin, leukemia, medullary carcinoma, medulloblastoma, melanoma, meningioma, mesothelioma, multiple myeloma, myelogenous leukemia, myeloma, myxosarcoma, neuroblastoma, oligodendroglioma, oral cancer, osteogenic sarcoma, ovarian cancer, pancreatic cancer, papillary adenocarcinomas, papillary carcinoma, peripheral T-cell lymphoma, pinealoma, polycythemia vera, prostate cancer, rectal cancer, renal cell carcinoma, retinoblastoma, rhabdomyosarcoma, sarcoma, sebaceous gland carcinoma, seminoma, skin cancer, small cell lung carcinoma, solid tumors, stomach cancer, squamous cell carcinoma, synovioma, sweat gland carcinoma, testicular cancer, thyroid cancer, Waldenström's macroglobulinemia, testicular tumors, uterine cancer, and Wilms' tumor.

18. The method of claim 17 , further comprising administering to the patient a therapeutically effective amount of of at least one additional therapeutic agent.