Antibody based reagents that specifically recognize toxic oligomeric forms of tau
The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomelic tau, fibrillar tau or non-disease associated forms of tau.
1. A binding molecule comprising at least 80% sequence identity to amino acid sequence SEQ ID NO:1.
2. A binding molecule comprising amino acid sequence SEQ ID NO:1, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13, SEQ ID NO:15, SEQ ID NO:17, or SEQ ID NO:19.
3. The binding molecule of claim 2 , wherein the binding molecule comprises amino acid sequence SEQ ID NO:1, SEQ ID NO:9 or SEQ ID NO:11.
4. The binding molecule of claim 2 , wherein the binding molecule binds to oligomeric tau and does not bind monomeric tau, fibrillar tau or non-disease associated forms of tau.