Method for producing 4-aminobutyric acid from algae
The invention relates to a process for the production of 4-aminobutyric acid, also referred to as gamma-aminobutyric acid, in short GABA, to a process for the production of an extract comprising 4-aminobutyric acid, to a process for the preparation of a cosmetic formulation comprising 4-aminobutyric acid, and to the use of Cyanidium caldarium cells or cell components in cosmetic applications.
1. A process for the production of 4-aminobutyric acid, comprising: culturing Cyanidium caldarium cells containing 4-aminobutyric acid in an aqueous medium; disrupting the Cyanidium caldarium cells to obtain solid cell components containing said 4-aminobutyric acid; and incorporating the disrupted Cyanidium caldarium cells comprising solid cell components containing said 4-aminobutryic acid in a cosmetic formulation.
2. The process according to claim 1 , wherein said Cyanidium caldarium cells are cultured at a temperature from 20° C. to 60° C.
3. The process according to claim 1 , wherein said culturing provides an aqueous medium having a pH at 25° C. of from 1.5 to 6.
4. The process according claim 1 , wherein said disrupting the Cyanidium caldarium cells is performed in an aqueous medium.
5. The process according to claim 1 , wherein said disrupting the Cyanidium caldarium cells comprises a hot-water disruption in combination with an enzymatic cell disruption.