Methods of colchicine administration
The invention provides improved methods for coadministration of colchicine with drugs metabolized by CYP3A4 (anciently referred to as cytochrome P450 isozyme 3A4) or the P-glycoprotein transporter, but not both. The method enables non-toxic coadministration of colchicine and the second drug at their ordinary levels safely and effectively without reducing the dose or frequency for either drug.
1. A method of administering colchicine to a patient in need thereof while concomitantly administering a second drug that is an inhibitor of P-glycoprotein 1 (P-gp) but is not an inhibitor of the cytochrome P450 3A4 isozyme (CYP3A4), wherein the second drug is propafenone, wherein the method comprises:
(a) administering to the patient a fixed maintenance dose of colchicine in an amount of from about 0.6 to about 1.2 mg/day, for a maintenance period of a plurality of days, without administering propafenone;
(b) after step (a), administering to the patient one or more therapeutically effective doses of the second drug; and
(c) concomitantly with step (b), administering to the patient the fixed maintenance dose of colchicine of step (a) without dose reduction.
2. The method of claim 1 , wherein the second drug is administered at a dose of from 225 mg/day to 450 mg/day.
3. The method of claim 1 , wherein the fixed maintenance dose of colchicine is 0.6 mg/day.
4. The method of claim 1 , wherein the fixed maintenance dose of colchicine is 1.2 mg/day.
5. The method of claim 1 , wherein the plurality of days comprises at least 7 days.
6. The method of claim 1 , wherein step (b) is performed after step (a).
7. The method of claim 1 , wherein the colchicine is administered to the patient for the prevention of gout flares.
8. A method of preventing gout flares in a patient in need thereof comprising administering colchicine while concomitantly administering a second drug that is an inhibitor of P-glycoprotein 1 (P-gp) but is not an inhibitor of the cytochrome P450 3A4 isozyme (CYP3A4), wherein the second drug is propafenone, wherein the method comprises:
(a) administering to the patient a fixed maintenance dose of colchicine in an amount of from about 0.6 to about 1.2 mg/day, for a maintenance period of a plurality of days, without administering propafenone;
(b) after step (a), administering to the patient one or more therapeutically effective doses of the second drug; and
(c) concomitantly with step (b), administering to the patient the fixed maintenance dose of colchicine of step (a) without dose reduction.
9. The method of claim 8 , wherein the second drug is administered at a dose of from 225 mg/day to 450 mg/day.
10. The method of claim 8 , wherein the fixed maintenance dose of colchicine is 0.6 mg/day.
11. The method of claim 8 , wherein the fixed maintenance dose of colchicine is 1.2 mg/day.
12. The method of claim 8 , wherein the plurality of days comprises at least 7 days.
13. The method of claim 8 , wherein step (b) is performed after step (a).