Treatment of gum diseases and gum disorders with TSG-6 protein
A method of treating or preventing a gum disease or gum disorder or gum injury in a mammal by administering to the mammal at least one inflammation modulatory or anti-inflammatory protein or polypeptide, such as TSG-6 protein, or a biologically active fragment, derivative, or analogue thereof. Gum diseases or gum disorders or gum injuries that may be treated include periodontal gum disease, and gum wounds resulting from gum surgeries.
1. A method of treating or preventing a gum disease or gum disorder or gum injury in a mammal comprising:
administering to said mammal, prior to the loss of bone that holds the teeth in place, tumor necrosis factor-α stimulated gene 6 (TSG-6) protein or a biologically active fragment, or derivative comprising a fragment thereof, wherein said TSG-6 protein or biologically active fragment, or derivative comprising a fragment, thereof is administered in an amount effective to treat or prevent said gum disease, gum disorder, or gum injury in said mammal.
2. The method of claim 1 wherein said TSG-6 protein or biologically active fragment, or derivative comprising a fragment thereof is administered systemically.
3. The method of claim 2 wherein said TSG-6 protein or biologically active fragment, or derivative comprising a fragment thereof is administered intravenously.
4. The method of claim 3 wherein said TSG-6 protein or biologically active fragment, or derivative comprising a fragment thereof is administered in an amount of from about 5 micrograms to about 500 milligrams.
5. The method of claim 4 wherein said TSG-6 protein or biologically active fragment, or derivative comprising a fragment thereof is administered in an amount of from about 100 milligrams to about 500 milligrams.
6. The method of claim 1 wherein said TSG-6 protein or biologically active fragment, or derivative comprising a fragment thereof is administered directly to the site of the gum disease, gum disorder, or gum injury.
7. The method of claim 6 wherein said TSG-6 protein or biologically active fragment, or derivative comprising a fragment thereof is administered in an amount of from about 0.1 microgram to about 1 milligram.
8. The method of claim 1 wherein said mammal is a primate.
9. The method of claim 8 wherein said primate is a human.
10. The method of claim 1 wherein said gum disease, gum disorder, or gum injury is a gingival wound.
11. The method of claim 10 wherein said TSG-6 protein or biologically active fragment, or derivative comprising a fragment thereof is administered within 6 hours of the occurrence of said gingival wound.
12. The method of claim 10 wherein said gingival wound results from a gum surgery.
13. The method of claim 12 wherein said gum surgery is a gingvectomy.
14. The method of claim 12 wherein said gum surgery is a gum flap surgery.
15. The method of claim 12 wherein said gum surgery is a gum tissue graft.
16. The method of claim 1 wherein said gum disease, gum disorder, or gum injury is periodontal gum disease.
17. The method of claim 1 wherein said gum disease, gum disorder, or gum injury is gingivitis.
18. The method of claim 1 wherein said TSG-6 protein or biologically active fragment, or derivative comprising a fragment thereof has the sequence (SEQ ID NO: 1).
19. The method of claim 1 wherein said TSG-6 protein or biologically active fragment, or derivative comprising a fragment thereof consists of amino acid residues 1 through 133 of (SEQ ID NO: 1).
20. The method of claim 1 wherein said TSG-6 protein or biologically active fragment, or derivative comprising a fragment thereof consists of amino acid residues 1 through 98 of (SEQ ID NO: 1).
21. A method of treating or preventing a gum disease, gum disorder, or gum injury in a mammal, comprising:
administering directly to the gum of said mammal tumor necrosis factor-αstimulated gene 6 (TSG-6) protein, or a biologically active fragment, or derivative comprising a fragment thereof, wherein said TSG-6 protein or biologically active fragment, or derivative comprising a fragment thereof is administered in an amount effective to treat or prevent said gum disease, gum disorder, or gum injury in said mammal.
22. The method of claim 21 wherein said TSG-6 protein or biologically active fragment, or derivative comprising a fragment thereof is administered in an amount of from about 0.1 microgram to about 1 milligram.
23. The method of claim 21 wherein said mammal is a primate.
24. The method of claim 23 wherein said primate is a human.
25. The method of claim 21 wherein said gum disease, gum disorder, or gum injury is a gingival wound.
26. The method of claim 25 wherein said TSG-6 protein or biologically active fragment, or derivative comprising a fragment thereof is administered to the gum of said mammal within 6 hours of the occurrence of said gingival wound.
27. The method of claim 25 wherein said gingival wound results from a gum surgery.
28. The method of claim 27 wherein said gum surgery is a gingivectomy.
29. The method of claim 27 wherein said gum surgery is a gum flap surgery.
30. The method of claim 27 wherein said gum surgery is a gum tissue graft.
31. The method of claim 21 wherein said gum disease, gum disorder, or gum injury is periodontal gum disease.
32. The method of claim 21 wherein said gum disease, gum disorder, or gum injury is gingivitis.
33. The method of claim 21 wherein said TSG-6 protein or biologically active fragment, or derivative comprising a fragment thereof has the sequence (SEQ ID NO: 1).
34. The method of claim 21 wherein said TSG-6 protein or biologically active fragment, or derivative comprising a fragment thereof consists of amino acid residues 1 through 133 of (SEQ ID NO: 1).
35. The method of claim 21 wherein said TSG-6 protein or biologically active fragment, or derivative comprising a fragment thereof consists of amino acid residues 1 through 98 of (SEQ ID NO: 1).