Bis-indolic derivatives, a process for preparing the same and their uses as a drug
Novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.
1. A product comprising a compound selected from the group consisting of:
2. A pharmaceutical composition, comprising:
a compound having a general formula selected from the group consisting of:
general formula VI:
wherein:
R 3 and R′ 3 represent independently from each other H, F, Cl, Br, I,
R represents a (C 1 -C 7 )-alkyl, CH 2 NHCO 2 (C 1 -C 7 )-alkyl, (CH 2 ) n OH, CH 2 NH(CH 2 ) n —OH, CH 2 NH(CH 2 ) n —NR a R b , CO 2 H, CO 2 —(C 1 -C 7 )-alkyl, CONH—(CH 2 ) n OH, CONH—(CH 2 ) n NR a R b , wherein R a and R b represents H, a linear or branched (C 1 -C 7 )-alkyl, a (C 3 -C 7 )-cycloalkyl, an aryl substituted or not, CH 2 -aryl, CO—(C 1 -C 7 )-alkyl, CO-aryl, CO 2 —(C 1 -C 7 )-alkyl, CO 2 -aryl, wherein aryl is a substituted or not aromatic group or a substituted or not heteroaromatic group and n=2 to 12;
general formula VII:
wherein:
R 4 and R′ 4 represent independently from each other H, F, Cl, Br, I,
R represents a (C 1 -C 7 )-alkyl, CH 2 NHCO 2 (C 1 -C 7 )-alkyl, (CH 2 ) n OH, CH 2 NH(CH 2 ) n —OH, CH 2 NH(CH 2 ) n —NR a R b , CO 2 H, CO 2 —(C 1 -C 7 )-alkyl, CONH—(CH 2 ) n OH, CONH—(CH 2 ) n NR a R b wherein R a , R b , and n being as defined above;
general formula VIII:
wherein:
R 3 and R′ 4 represent independently from each other F, Cl, Br, I,
R represents a (C 1 -C 7 )-alkyl, CH 2 NHCO 2 (C 1 -C 7 )-alkyl, (CH 2 ) n OH, CH 2 NH(CH 2 ) n —OH, CH 2 NH(CH 2 ) n —NR a R b , CO 2 H, CO 2 —(C 1 -C 7 )-alkyl, CONH—(CH 2 ) n OH, CONH—(CH 2 ) n NR a R b wherein R a , R b , and n being as defined above;
general formula IX:
wherein:
R 4 and R′ 3 represent independently from each other F, Cl, Br, I,
R represents a (C 1 -C 7 )-alkyl, CH 2 NHCO 2 (C 1 -C 7 )-alkyl, CO 2 H, (CH 2 ) n OH, CH 2 NH(CH 2 ) n —OH, CH 2 NH(CH 2 ) n —NR a R b , CO 2 —(C 1 -C 7 )-alkyl, CONH—(CH 2 ) n OH, CONH—(CH 2 ) n NR a R b wherein R a , R b , and n being as defined above;
general formula X:
wherein:
R 3 and R′ 3 represent independently from each other F, Cl, Br, I,
R represents a (C 1 -C 7 )-alkyl, CH 2 NHCO 2 (C 1 -C 7 )-alkyl, (CH 2 ) n OH, CH 2 NH(CH 2 ) n —OH, CH 2 NH(CH 2 ) n —NR a R b , CO 2 H, CO 2 —(C 1 -C 7 )-alkyl, CONH—(CH 2 ) n OH, CONH—(CH 2 ) n NR a R b ,
R′ 6 represents a (C 1 -C 7 )-alkyl wherein R a , R b , and n being as defined above; and
general formula XI:
wherein:
R represents a (C 1 -C 7 )-alkyl, CH 2 NHCO 2 (C 1 -C 7 )-alkyl; and
a pharmaceutically acceptable vehicle.
3. A pharmaceutical composition, comprising:
a compound selected from the group consisting of:
a pharmaceutically acceptable vehicle.