Granted Patent
B2
US 9,676,760 · App. 15/152,231 · Granted Jun 13, 2017
Fused heterocyclic compounds as ion channel modulators
Inventors:
Britton Kenneth Corkey (Redwood City, CA); Elfatih Elzein (Fremont, CA); Michael Graupe (Pacifica, CA); Juan Guerrero (Concord, CA); Robert H. Jiang (Cupertino, CA); Rao V. Kalla (Cupertino, CA); Dmitry Koltun (Foster City, CA); Xiaofen Li (Mountain View, CA); Ruben Martinez (San Diego, CA); Eric Q. Parkhill (San Francisco, CA); Thao Perry (San Jose, CA); Chandrasekar Venkataramani (Redwood City, CA); Jeff Zablocki (Los Altos, CA)
Assignee:
Gilead Sciences, Inc.
C07D413/06A61K31/553A61K31/5513C07B59/002C07D243/14C07D243/24C07D267/08C07D267/14C07D291/08C07D403/06C07D413/04C07D413/12C07D413/14C07D417/14C07D419/06C07D471/04C07D487/04C07D498/04C07B2200/05
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Abstract
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Z 1 , Z 2 , Z 3 , Z 4 , X, Y, R 2 , R 3 and R 4 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
Claims (3)
1. A compound of formula:
2. A pharmaceutical composition comprising a compound of formula:
and a pharmaceutically acceptable carrier.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 13, 2016
From: CORKEY, BRITTON KENNETH; ELZEIN, ELFATIH; JIANG, ROBERT H.; KALLA, RAO V.; KOLTUN, DMITRY; LI, XIAOFEN; MARTINEZ, RUBEN; PARKHILL, ERIC Q.; PERRY, THAO; ZABLOCKI, JEFF; VENKATARAMANI, CHANDRASEKAR; GRAUPE, MICHAEL; GUERRERO, JUAN
To: GILEAD SCIENCES, INC.
Reel/Frame 038582/0976 →
Continuity (7)
Provisional Application
61582160
· Dec 30, 2011
Provisional Application
61503980
· Jul 1, 2011