Non-racemic mixtures of various ratios of D- and L-methadone and methods of treating pain using the same
View Patent ↗Non-racemic mixtures of D- and L-methadone containing a ratio ranging from about 2.5:1 to about 3.5:1 by weight of D-methadone to L-methadone, such as for example about 2.9:1 to about 3.1:1 by weight of D-methadone to L-methadone, or about 3:1 by weight of D-methadone to L-methadone, have been found to exhibit surprising and unexpected beneficial results in the treatment of neuropathic pain. Additionally, non-racemic mixtures of D- and L-methadone containing a ratio ranging from about 2.5:1 to about 3.5:1 by weight of D-methadone to L-methadone, about 2.9:1 to about 3.1:1 by weight of D-methadone to L-methadone, or for example about 3:1 by weight of D-methadone to L-methadone, in combination with other non-methadone opioids have been found to exhibit surprising and unexpected beneficial results in the treatment of mixed pain.
1. A pharmaceutical composition comprising a non-racemic mixture of D-methadone or pharmaceutically acceptable salt thereof and L-methadone or pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, wherein the D-methadone or pharmaceutically acceptable salt thereof and L-methadone or pharmaceutically acceptable salt thereof are present in a ratio of about 3:1.
2. The pharmaceutical composition according to claim 1 , further comprising a pharmacologically effective amount of a non-methadone opioid.
3. The pharmaceutical composition according to claim 1 , further comprising a partial opioid agonist.
4. The pharmaceutical composition according to claim 1 , further comprising a non-opioid analgesic.
5. The pharmaceutical composition according to claim 1 , further comprising a skeletal muscle relaxant.
6. The pharmaceutical composition according to claim 1 , further comprising a nonbarbiturate sedative.
7. A method for treatment of neuropathic pain in a subject comprising administering the pharmaceutical composition of claim 1 .
8. A pharmaceutical composition comprising a non-racemic mixture of D-methadone or pharmaceutically acceptable salt thereof and L-methadone or pharmaceutically acceptable salt thereof, at least one non-methadone opioid and a pharmaceutically acceptable carrier, wherein the D-methadone or pharmaceutically acceptable salt thereof and L-methadone or pharmaceutically acceptable salt thereof are present in a ratio of about 3:1.
9. A method for treatment of mixed pain in a subject comprising administering the pharmaceutical composition of claim 8 .