Selective EP4 receptor antagonistic substance for treatment of cancer
This invention provides a medicament for the treatment of cancer, which cause a reduction of cancer. This invention relates to use of a compound which has inhibitory activities against prostaglandin E2 receptor (EP4 receptor) and is represented by the following general formula (I), (II), (III), or (IV), or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising the compound or the salt for the manufacture of a medicament for the treatment of cancer. The invention relates to a method for treatment of cancer comprising administering the compound or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising the compound or the salt to humans or animals. The compound or a pharmaceutically acceptable salt thereof, or the pharmaceutical composition may be used in combination with one or more second active agents.
1. A method for the treatment of colon cancer or breast cancer in which COX-2/PGE2 is expressed, which comprises administering an effective amount of a compound selected from the group consisting of:
3-[2-(4-{2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl}phenyl)ethyl]-1-[(4-methylbenzene)sulfonyl]urea;
4-((1S)-1-{[5-chloro-2-(4-fluorophenoxy)benzoyl]amino}ethyl)benzoic acid; and
4-[(1S)-1-({[5-chloro-2-(3-fluorophenoxy)pyridin-3-yl]carbonyl}amino)ethyl]-benzoic acid, or a pharmaceutically acceptable salt thereof to a human or an animal.
2. A method for reducing colon cancer tissues or breast cancer tissues in which COX-2/PGE2 is expressed, which comprises contacting the cancer tissues with a compound selected from the group consisting of:
3-[2-(4-{2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl}phenyl)ethyl]-1-[(4-methylbenzene)sulfonyl]urea;
4-((1S)-1-{5-chloro-2-(4-fluorophenoxy)benzoyl]amino}ethyl)benzoic acid; and
4-[(1S)-1-({[5-chloro-2-(3-fluorophenoxy)pyridin-3-yl]carbonyl}amino)ethyl]-benzoic acid, or a pharmaceutically acceptable salt thereof.
3. The method according to claim 1 , further comprising combining the compound of 3-[2-(4-{2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl}phenyl)ethyl]-1-(4-methylbenzene)sulfonyl]urea,
4-((1 S)-1-{[5-chloro-2-(4-fluorophenoxy)benzoyl]amino}ethyl)benzoic acid, or
4-[(1 S)-1-({[5-chloro-2-(3-fluorophenoxy)pyridin-3-yl]carbonyl}amino)ethyl]-benzoic acid, or the pharmaceutically acceptable salt thereof, with at least one additional active agent.
4. The method according to claim 3 , wherein the additional active agent is at least one selected from the group consisting of a steroidal or nonsteroidal antiandrogen agent, an antiestrogen agent, a chemotherapeutic agent, a GnRH antagonistic peptide, an alpha-reductase inhibitor, an alpha-receptor inhibitor, an aromatase inhibitor, a 17beta-hydroxysteroid dehydrogenase inhibitor, an adrenal androgen production inhibitor, a kinase inhibitor, a drug for hormone therapy, and a drug inhibiting cell growth factor or its receptor.
5. The method according to claim 1 , wherein the cancer further expresses an EP4 receptor.
6. The method according to claim 2 , wherein the cancer tissues further express an EP4 receptor.